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NAT10 regulates mitotic cell fate by acetylating Eg5 to control bipolar spindle assembly and chromosome segregation
Cell fate of mitotic cell is controlled by spindle assembly. Deficient spindle assembly results in mitotic catastrophe leading to cell death to...
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Knockdown of TACC3 inhibits tumor cell proliferation and increases chemosensitivity in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant digestive tract tumor with limited clinical treatments. Transforming acidic...
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Kinesin-5 Eg5 is essential for spindle assembly, chromosome stability and organogenesis in development
Chromosome stability relies on bipolar spindle assembly and faithful chromosome segregation during cell division. Kinesin-5 Eg5 is a...
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Research progress on morphology and mechanism of programmed cell death
Programmed cell death (PCD) is a basic process of life that is closely related to the growth, development, aging and disease of organisms and is one...
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Quantifying Changes in Chromosome Position to Assess Chromokinesin Activity
The chromokinesin KIF22 (Kid, kinesin-10 family) is the primary generator of polar ejection forces, which contribute to chromosome positioning and...
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Kinesin-5 Eg5 mediates centrosome separation to control spindle assembly in spermatocytes
Timely and accurate centrosome separation is critical for bipolar spindle organization and faithful chromosome segregation during cell division....
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Microalgae Cell Wall Disruption and Biocomponents Fractionation for Fuel Conversion
Major environmental issues of current decades focus on lowering the carbon footprints and global temperature rise. Conversion of microalgae biomass...
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Boron Derivatives Inhibit the Proliferation of Breast Cancer Cells and Affect Tumor-Specific T Cell Activity In Vitro by Distinct Mechanisms
Breast cancer is the most frequently diagnosed cancer among women worldwide. Despite the initial clinical response obtained with the widely used...
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Effect of nanosecond pulsed electric fields (nsPEFs) on coronavirus survival
Previous work demonstrated inactivation of influenza virus by GHz frequency electromagnetic fields. Despite theoretical and experimental results, the...
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Methods for Investigating Cell Division Mechanisms in C. elegans
The nematode Caenorhabditis elegans is a widely used model organism for the study of mitotic and meiotic cell division. These self-fertilizing worms...
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Non-random chromosome segregation and chromosome eliminations in the fly Bradysia (Sciara)
Mendelian inheritance is based upon random segregation of homologous chromosomes during meiosis and perfect duplication and division of chromosomes...
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Cyclers’ kinases in cell division: from molecules to cancer therapy
Faithful eucaryotic cell division requires spatio-temporal orchestration of multiple sequential events. To ensure the dynamic nature of these...
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YAP1 inhibits RSL3-induced castration-resistant prostate cancer cell ferroptosis by driving glutamine uptake and metabolism to GSH
High levels of YAP1 and ferroptosis activation in castration-resistant prostate cancer (CRPC) can inhibit CRPC progression and improve its...
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MD simulation-based screening approach identified tolvaptan as a potential inhibitor of Eg5
We discovered tolvaptan as a new Eg5 inhibitor using molecular dynamics simulation-based virtual screening. The Eg5-monastrol, Eg5-ispinesib, and...
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The therapeutic effect of KSP inhibitors in preclinical models of cholangiocarcinoma
Cholangiocarcinoma (CCA) is an epithelial malignancy with a dismal prognosis owing to limited treatment options. Here, we identified several compound...
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Genetic interaction between PLK1 and downstream MCPH proteins in the control of centrosome asymmetry and cell fate during neural progenitor division
Alteration of centrosome function and dynamics results in major defects during chromosome segregation and is associated with primary autosomal...
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A link between mitotic defects and mitotic catastrophe: detection and cell fate
Although the phenomenon of mitotic catastrophe was first described more than 80 years ago, only recently has this term been used to explain a...
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A single-cell transcriptomic atlas tracking the neural basis of division of labour in an ant superorganism
Ant colonies with permanent division of labour between castes and highly distinct roles of the sexes have been conceptualized to be superorganisms,...
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The Centrosome Cycle
Centrosomes are dynamic organelles involved in many aspects of cell function and growth. Centrosomes act as microtubule organizing centers, and...
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Chemical Biology of Mitotic Spindle Assembly Motors
Mitotic kinesins play essential roles during mitotic spindle assembly and in ensuring proper chromosome segregation. Chemical inhibitors of mitotic...