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Investigation of spirooxindole-pyrrolidine derivatives as acetylcholinesterase inhibitors using molecular docking/dynamics simulations, bioisosteric replacement, MEP, and ADME/Tox properties
Acetylcholinesterase is used as a key target in the treatment of Alzheimer's disease. Recently, a series of new spirooxindolepyrrolidine derivatives...
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3D-QSAR assisted identification of selective CYP1B1 inhibitors: an effective bioisosteric replacement/molecular docking/electrostatic complementarity analysis
Cytochrome P450-1B1 is a majorly overexpressed drug-metabolizing enzyme in tumors and is responsible for inactivation and subsequent resistance to a...
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The importance of species addition ‘versus’ replacement varies over succession in plant communities after glacier retreat
The mechanisms underlying plant succession remain highly debated. Due to the local scope of most studies, we lack a global quantification of the...
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Enzymes in Molecular Biotechnology
Molecular biotechnology uses a wide variety of enzymes. These can be grouped either to their reaction mechanism (enzyme class) or to the intended use...
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Combined RNA interference and gene replacement therapy targeting MFN2 as proof of principle for the treatment of Charcot–Marie–Tooth type 2A
Mitofusin-2 (MFN2) is an outer mitochondrial membrane protein essential for mitochondrial networking in most cells. Autosomal dominant mutations in...
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High-Throughput Structure-Based Drug Design (HT-SBDD) Using Drug Docking, Fragment Molecular Orbital Calculations, and Molecular Dynamic Techniques
Structure-based drug design (SBDD) is rapidly evolving to be a fundamental tool for faster and more cost-effective methods of lead drug discovery....
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Molecular responses of higher plants to dehydration
A massive amount of data has been accumulating on the molecular responses of plants to water deficit. In plants, dehydration activates a protective...
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Molecular Markers for Mutant Characterization
Mutants are either obtained spontaneously or artificially induced frequently in various organisms to serve several purposes like expanding the...
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Evolutionary honing in and mutational replacement: how long-term directed mutational responses to specific environmental pressures are possible
Recent results have shown that the human malaria-resistant hemoglobin S mutation originates de novo more frequently in the gene and in the population...
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Ribonucleoprotein (RNP)-Mediated Allele Replacement in Barley (Hordeum vulgare L.) Leaves
Varietal differences within a species with agronomic importance are often based on minor changes in the genomic sequence. For example,...
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Review of Local Cellular and Molecular Processes of Bone Tissue Regeneration Induced by Calcium Phosphate Materials
AbstractOne of the leading causes of hospitalization, disability, and mortality in 50% of women and 20% of men in age group over 50 years of age is...
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Targeting Chloroplasts for Plant Molecular Farming
Chloroplast transformation has emerged as a promising platform for the development of modified transplastomic plants expressing many useful products...
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Applications of Molecular Biology in Agriculture
Detailed knowledge of the processes involved in the central dogma of molecular biology has enabled the direct or indirect use of DNA in molecular...
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Molecular Farming of Pharmaceutical Proteins in Different Crop Systems: A Way Forward
Molecular farmingMolecular farming is commonly associated with the exploitation of plant cell cultures, parts of or whole plants, aiming to obtain...
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Identification of a novel type of focal adhesion remodelling via FAK/FRNK replacement, and its contribution to cancer progression
Numerous studies have investigated the various cellular responses against genotoxic stress, including those mediated by focal adhesions. We here...
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Molecular Farming of Industrial Enzymes: Products and Applications
As the size of the human population increased over the last few thousand years, human inventions were made to assist with the ease of survival and...
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Past, present, and future of cell replacement therapy for parkinson’s disease: a novel emphasis on host immune responses
Parkinson’s disease (PD) stands as the second most common neurodegenerative disorder after Alzheimer’s disease, and its prevalence continues to rise...
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On Protein Loops, Prior Molecular States and Common Ancestors of Life
The principle of continuity demands the existence of prior molecular states and common ancestors responsible for extant macromolecular structure....
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Brewer’s spent yeast replacement in carp diet leads to muscle biomass production, recycling, waste management and resource conservation
Brewer’s spent yeast (BSY) is among the most voluminous by-products generated in brewery industry that adds to the waste; however, smart utilization...
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Improving Plant Molecular Farming via Genome Editing
Once plant genetic modification began in the 1980s, plants have provided humans with useful agriculture products, but in the last 30 years, they have...