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PI3K/AKT/FOXO3a Pathway Induces Muscle Atrophy by Ubiquitin-Proteasome System and Autophagy System in COPD Rat Model
Muscle atrophy is a common extrapulmonary co-morbidity affecting about 20% of patients with COPD. However, the mechanism of muscle atrophy in COPD...
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A model for evolutionary rescue through plant mating system
As reported by experimental studies, changes in pollination regime are expected to drive plant mating system evolution. In natural populations facing...
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Flash floods in Mediterranean catchments: a meta-model decision support system based on Bayesian networks
Natural disasters, especially those related to water—like storms and floods—have increased over the last decades both in number and intensity. Under...
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Generation of the NeoThy mouse model for human immune system studies
Humanized mouse models, created via transplantation of human hematopoietic tissues into immune-deficient mice, support a number of research...
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Drosophila olfaction as a model system for studying human neurological disorders
The fruit fly, Drosophila melanogaster , has been one of the finest systems for decoding myriad puzzles across different domains of biology. Beyond...
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Supply Chain Model to Compare the Biorefinery Economics and Environmental Performance of Baled and Pelleted Biomass System
A supply chain model for an economic and environmental assessment of pelleted and baled corn stover was developed based on minimizing the total cost...
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Model-based surveillance system design under practical constraints with application to white-nose syndrome
Infectious diseases are powerful ecological forces structuring ecosystems, causing devastating economic impacts and disrupting society. Successful...
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Chlorogenic acid modulates the ubiquitin–proteasome system in stroke animal model
BackgroundChlorogenic acid, a phenolic compound, has potent antioxidant and neuroprotective properties. The ubiquitin–proteasome system is an...
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Heterologous gene expression system for the production of hydrolyzable tannin intermediates in herbaceous model plants
Aluminum toxicity is the main factor limiting the elongation of plant roots in acidic soil. The tree species Eucalyptus camaldulensis is considerably...
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A Planarian Model System to Study Host-Pathogen Interactions
This protocol is focused on using the recently established planarian infection model system to study host-pathogen interactions during fungal...
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Develo** a CRISPR System in Nongenetic Model Polyploids
The genetic consequences following polyploidy (i.e., whole-genome duplication; WGD) vary greatly across organisms and through time since...
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The REBURN model: simulating system-level forest succession and wildfire dynamics
BackgroundHistorically, reburn dynamics from cultural and lightning ignitions were central to the ecology of fire in the western United States (wUS),...
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A real options model for evaluating a tree and mushroom vertical agroforestry system in Shandong, China
A vertical agroforestry system composing of fast-growing and high-yield poplar ( Populus sp. ) trees and underwood button mushroom (BM) ( Agaricus...
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Establishment of in vitro pollen germination system in C4 model plant Foxtail Millet
The development and germination of pollen play crucial roles in the sexual reproduction of plants, and this process holds great potential for...
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A hypothetical model of phytoremediation for bioremediation of heavy metals toxicity in agricultural system
Heavy metals contamination in agricultural soils has become a significant concern due to its detrimental effects on crop growth, productivity and...
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Alterations in the Properties of the Rat Hippocampus Glutamatergic System in the Lithium-Pilocarpine Model of Temporal Lobe Epilepsy
AbstractStatus epilepticus (SE) triggers many not yet fully understood pathological changes in the nervous system that can lead to the development of...
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The mesocortical dopaminergic system cannot explain hyperactivity in an animal model of attention deficit hyperactivity disorder (ADHD)- Spontaneously hypertensive rats (SHR)
BackgroundAttention deficit hyperactivity disorder (ADHD) is one of the most prevalent neuropsychiatric disorders with morphological brain...
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Factors That Shaped the Forestry Extension System in Japan: Adoption and Adaptation of the United States Model After World War II
Systems for small-scale forestry are occasionally shaped by adopting models used by other countries. Such adoption is localized and adapted to suit...
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Daphnia as a versatile model system in ecology and evolution
Water fleas of the genus Daphnia have been a model system for hundreds of years and is among the best studied ecological model organisms to date. Daphnia...
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Modeling cancer immunoediting in tumor microenvironment with system characterization through the ising-model Hamiltonian
Background and objectiveCancer Immunoediting (CI) describes the cellular-level interaction between tumor cells and the Immune System (IS) that takes...
