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Exposure of the inner mitochondrial membrane triggers apoptotic mitophagy
During apoptosis mediated by the intrinsic pathway, BAX/BAK triggers mitochondrial permeabilization and the release of cytochrome- c , followed by a...
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ANT2 functions as a translocon for mitochondrial cross-membrane translocation of RNAs
Bidirectional transcription of mammalian mitochondrial DNA generates overlap** transcripts that are capable of forming double-stranded RNA (dsRNA)...
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Pore-Forming VDAC Proteins of the Outer Mitochondrial Membrane: Regulation and Pathophysiological Role
AbstractVoltage-dependent anion channels (VDAC1-3) of the outer mitochondrial membrane are a family of pore-forming β-barrel proteins that carry out...
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Curvature sensing lipid dynamics in a mitochondrial inner membrane model
Membrane curvature is essential for many cellular structures and processes, and factors such as leaflet asymmetry, lipid composition, and proteins...
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Assessment of Mitochondrial Protein Topology and Membrane Insertion
Analyzing the membrane integrity and topology of a mitochondrial protein is essential for truly understanding its function. In this chapter, we...
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Optogenetic rejuvenation of mitochondrial membrane potential extends C. elegans lifespan
Mitochondrial dysfunction plays a central role in aging but the exact biological causes are still being determined. Here, we show that...
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NLG1, encoding a mitochondrial membrane protein, controls leaf and grain development in rice
BackgroundMitochondrion is the key respiratory organ and participate in multiple anabolism and catabolism pathways in eukaryote. However, the...
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Mitochondrial surface coating with artificial lipid membrane improves the transfer efficacy
Extracellular mitochondria are present and act as non-cell-autonomous signals to support energetic homeostasis. While mitochondria allograft is a...
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Downhill running induced DNA damage enhances mitochondrial membrane permeability by facilitating ER-mitochondria signaling
To observe whether downhill running can lead to DNA damage in skeletal muscle cells and changes in mitochondrial membrane permeability and to explore...
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Preservation of mitochondrial membrane potential is necessary for lifespan extension from dietary restriction
Dietary restriction (DR) increases lifespan in many organisms, but its underlying mechanisms are not fully understood. Mitochondria play a central...
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Modular Assembly of Mitochondrial β-Barrel Proteins
Mitochondrial β-barrel proteins fulfill crucial roles in the biogenesis and function of the cell organelle. They mediate the import and membrane...
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Exploring the limitations of mitochondrial dye as a genuine horizontal mitochondrial transfer surrogate
Rosamine-based mitochondrial dyes, such as Mitotracker Red, have commonly been employed to visualize mitochondrial localization within cells due to...
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Novel functions of the ER-located Hsp40s DNAJB12 and DNAJB14 on proteins at the outer mitochondrial membrane under stress mediated by CCCP
The endoplasmic reticulum (ER) membrane provides infrastructure for intracellular signaling, protein degradation, and communication among the ER...
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MICU1 controls spatial membrane potential gradients and guides Ca2+ fluxes within mitochondrial substructures
Mitochondrial ultrastructure represents a pinnacle of form and function, with the inner mitochondrial membrane (IMM) forming isolated pockets of...
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EFHD1 promotes osteosarcoma proliferation and drug resistance by inhibiting the opening of the mitochondrial membrane permeability transition pore (mPTP) by binding to ANT3
Chemoresistance is the main obstacle in the clinical treatment of osteosarcoma (OS). In this study, we investigated the role of EF-hand...
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Reactive oxygen species and depolarization the inner mitochondrial membrane under effect of synthetic auxin herbicides in plant cell culture of Arabidopsis thaliana L.
The cytotoxic effect of synthetic analogs of auxins, namely 2.4-D and clopyralid on heterotrophic cell suspension culture of Arabidopsis thaliana ,...
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Tracking the Activity and Position of Mitochondrial β-Barrel Proteins
Total interference reflection fluorescence (TIRF) microscopy of lipid bilayers is an effective technique for studying the lateral movement and ion...
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Assessment of Mitochondrial Dysfunctions After Sirtuin Inhibition
Posttranslational modifications are important for protein functions and cellular signaling pathways. The acetylation of lysine residues is catalyzed...
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Ca2+-mediated mitochondrial inner membrane permeabilization induces cell death independently of Bax and Bak
The ability of mitochondria to buffer a rapid rise in cytosolic Ca 2+ is a hallmark of proper cell homeostasis. Here, we employed m-3M3FBS, a putative...
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Monitoring Mitochondrial Membrane Potential in Live Cells Using Time-Lapse Fluorescence Imaging
The mitochondrial membrane potential (ΔΨm) generated by proton pumps (Complexes I, III, and IV) is an essential component in the process of energy...