Search
Search Results
-
rKOMICS: an R package for processing mitochondrial minicircle assemblies in population-scale genome projects
BackgroundThe advent of population-scale genome projects has revolutionized our biological understanding of parasitic protozoa. However, while...
-
Gene engineered mesenchymal stem cells: greater transgene expression and efficacy with minicircle vs. plasmid DNA vectors in a mouse model of acute lung injury
BackgroundAcute lung injury (ALI) and in its severe form, acute respiratory distress syndrome (ARDS), results in increased pulmonary vascular...
-
Suitability of double-stranded DNA as a molecular standard for the validation of analytical ultracentrifugation instruments
To address the current lack of validated molecular standards for analytical ultracentrifugation (AUC), we investigated the suitability of...
-
Minicircle DNA vector expressing interferon-lambda-3 inhibits hepatitis B virus replication and expression in hepatocyte-derived cell line
BackgroundInterferon-alpha (IFNα) is a first-line treatment option for chronic hepatitis B virus (HBV) infection, but the severe systemic...
-
Pooled multicolour tagging for visualizing subcellular protein dynamics
Imaging-based methods are widely used for studying the subcellular localization of proteins in living cells. While routine for individual proteins,...
-
Rolling Circle Replication and Bypass of Damaged Nucleotides
Faithful mitochondrial DNA (mtDNA) replication is critical for the proper function of the oxidative phosphorylation system. Problems with mtDNA...
-
Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-directed integrases
Programmable genome integration of large, diverse DNA cargo without DNA repair of exposed DNA double-strand breaks remains an unsolved challenge in...
-
Molecular evidence of Leishmania spp. in spider monkeys (Ateles geoffroyi) from The Tuxtlas Biosphere Reserve, Veracruz, Mexico
The black-handed spider monkey ( Ateles geoffroyi ) is a platyrrhine primate distributed in southern Mexico, Central America, and part of South...
-
Bi-FoRe: an efficient bidirectional knockin strategy to generate pairwise conditional alleles with fluorescent indicators
Gene expression labeling and conditional manipulation of gene function are important for elaborate dissection of gene function. However, contemporary...
-
Rapid and robust derivation of mesenchymal stem cells from human pluripotent stem cells via temporal induction of neuralized ectoderm
BackgroundMesenchymal stem cells (MSCs) are emerging as the mainstay of regenerative medicine because of their ability to differentiate into multiple...
-
Correction to: Minicircle DNA vector expressing interferon-lambda-3 inhibits hepatitis B virus replication and expression in hepatocyte-derived cell line
Following publication of the original article [1], the authors reported an error that occurred during the production process.
-
Methyltransferase-like protein 7A (METTL7A) promotes cell survival and osteogenic differentiation under metabolic stress
While bone has an inherent capacity to heal itself, it is very difficult to reconstitute large bone defects. Regenerative medicine, including stem...
-
Evolution of myxozoan mitochondrial genomes: insights from myxobolids
BackgroundMyxozoa is a class of cnidarian parasites that encompasses over 2,400 species. Phylogenetic relationships among myxozoans remain highly...
-
Plastid engineering using episomal DNA
Key messageNovel episomal systems have the potential to accelerate plastid genetic engineering for application in plant synthetic biology.
...
-
Genoty** of Trypanosoma brucei evansi in Egyptian camels: detection of a different non-RoTat 1.2 Trypanosoma brucei evansi in Egyptian camels
Trypanosoma brucei evansi ( T. b. evansi ) is an enzootic organism found in Egyptian camels, which genetically classified into types A and B. To detect...
-
Atomistic Molecular Dynamics Simulations of DNA in Complex 3D Arrangements for Comparison with Lower Resolution Structural Experiments
Atomic-level computer simulations are a very useful tool for describing the structure and dynamics of complex biomolecules such as DNA and for...
-
Diversity and antibiograms of bacteria isolated from cutaneous leishmaniasis wounds in the Nkwanta South District of Ghana
Leishmaniasis is a vector-borne disease caused by an intracellular protozoan parasite. The presence of secondary bacterial infections in cutaneous...
-
Differing lesion recovery rates of two Caribbean stony coral species across a shallow water to mesophotic depth gradient suggest different sensitivity to repeated disturbance
Following major stress events such as storms, bleaching events, or disease outbreaks, surviving corals must regenerate tissue to recover. We aimed to...
-
Nodular pyogranulomatous panniculitis due to Leishmania infantum infection in a domestic ferret (Mustela putorius furo)
Leishmaniosis is a vector-borne disease caused by different Leishmania species and transmitted by phlebotomine sand flies under natural conditions in...
