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MicroRNA-133 suppresses cell viability and migration of rheumatoid arthritis fibroblast-like synoviocytes by down-regulation of MET, EGFR, and FSCN1 expression
Aberrant proliferation and migration of fibroblast-like synoviocytes (FLS) are major characteristics of rheumatoid arthritis (RA). MicroRNA-133...
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MicroRNA-specific therapeutic targets and biomarkers of apoptosis following myocardial ischemia–reperfusion injury
MicroRNAs are single-stranded non-coding RNAs that participate in post-transcriptional regulation of gene expression, it is involved in the...
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Analysis of mRNA and MicroRNA Expression Profiles of Nervous Tissues and Reproductive Tissues in Male Procambarus clarkii After Silencing IAG
The insulin-like androgenic gland hormone gene ( IAG ), primarily expressed in the androgenic gland (AG), plays a crucial role in controlling male sex...
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Diabetic kidney disease induces transcriptome alterations associated with angiogenesis activity in human mesenchymal stromal cells
BackgroundTherapeutic interventions that optimize angiogenic activities may reduce rates of end-stage kidney disease, critical limb ischemia, and...
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Morphologic and genomic changes of thyroid cancer cell lines exposed to conditions of simulated microgravity
Microgravity in space impacts human health. In particular, thyroid cancer, which has a high incidence rate, has been the subject of numerous studies...
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Overview of Computational and Experimental Methods to Identify Tissue-Specific MicroRNA Targets
As ubiquitous posttranscriptional regulators of gene expression, microRNAs (miRNAs) play key roles in cell physiology and function across taxa. In...
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Regulation of insect behavior by non-coding RNAs
The adaptation of insects to environments relies on a sophisticated set of behaviors controlled by molecular and physiological processes. Over the...
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Rephrasing the ‘David-Goliath’ story in the field of diabetes
Diabetes Mellitus has become a serious threat to public health. This non-communicable disease is spreading like wildfire to shape in the form of a...
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Changes in Electrophysiological Features of Rats’ Working Atrial Myocardium after Its Lipotransfection with MicroRNAs miR-1-3p, miR-153-3p, or miR-133a-3p
AbstractMicroRNA is a small, single-stranded nucleotide sequence, which can regulate gene expression at the posttranscriptional level. To date, it is...
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MicroRNA: Role in Gene Regulation, Disease Prognosis, Radiotherapy, and the Activity of Radioprotectors
AbstractMicroRNAs are small, highly conserved noncoding RNAs (containing about 20 nucleotides), involved in the regulation of gene activity on the...
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The Crosstalk between Coronary Artery Bypass Grafting and miRNAs
AbstractMiRNAs, which are small noncoding RNA molecules that regulate over 60% of genes, modulate gene expression. MiRNAs have been implicated in...
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Identifying Biomarkers for Osteogenic Potency Assay Development
There has been extensive exploration of how cells may serve as advanced therapy medicinal products to treat skeletal pathologies. Osteoblast...
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Integrated mRNA and Small RNA Sequencing Reveals Regulatory Expression of Larval Metamorphosis of the Razor Clam
The razor clam, Sinonovacula constricta , is an important economic marine shellfish, and its larval development involves obvious morphological and...
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The Significance of Repressive Processes in Developmental Regulation
Encountering a developmental process confined to a limited time window or a restricted embryonic area, one may deem that the mechanism to activate...
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MicroRNA delivery based on nanoparticles of cardiovascular diseases
Cardiovascular disease, especially myocardial infarction, is a serious threat to human health. Many drugs currently used cannot achieve the desired...
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The Role of MiRNA in Cancer: Pathogenesis, Diagnosis, and Treatment
Cancer is also determined by the alterations of oncogenes and tumor suppressor genes. These gene expressions can be regulated by microRNAs (miRNA)....
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Multiple omics levels of chronic lymphocytic leukemia
Chronic lymphocytic leukemia (CLL) is a lymphoproliferative malignancy characterized by the proliferation of functionally mature but incompetent B...
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MicroRNAs as prospective biomarkers, therapeutic targets and pharmaceuticals in neuroblastoma
Neuroblastomas, the most prevalent malignant solid neoplasms of childhood, originate from progenitor cells of the sympathetic nervous system. Their...
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Mechanisms of Heavy Metal Cadmium (Cd)-Induced Malignancy
The environmental pollution of cadmium is worsening, and its significant carcinogenic effects on humans have been confirmed. Cadmium can induce...
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miRNAs in radiotherapy resistance of cancer; a comprehensive review
While intensity-modulated radiation therapy-based comprehensive therapy increases outcomes, cancer patients still have a low five-year survival rate...
