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Methylation-Specific Electrophoresis
Methylation of CpG sites in the promoter region of genomic DNA is an important epigenetic modification that plays a critical role in gene regulation,...
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Phasing DNA Methylation
Haploty** enables the study of allele-specific events. Heterozygous variants, primarily single nucleotide variants (SNVs), enable the assignment of...
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DNA Methylation in Ctenophores
Epigenomic regulation and dynamic DNA methylation, in particular, are widespread mechanisms orchestrating the genome operation across time and...
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The Generation and Recognition of Histone Methylation
The posttranslational modification of histone proteins via methylation has important functions in gene activation, transcriptional silencing,...
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Methylome Imputation by Methylation Patterns
DNA methylation is studied extensively for its relations with several biological processes such as transcriptional regulation. While methylation...
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Global DNA Methylation and Cognitive Impairment: A Population-Based Study from Haryana, North India
Epigenetic modifications have been implicated in the development of cognitive impairment. However, the relationship between DNA methylation levels...
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Estimating genome-wide DNA methylation heterogeneity with methylation patterns
BackgroundIn a heterogeneous population of cells, individual cells can behave differently and respond variably to the environment. This cellular...
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DNA Methylation Analysis of Cnr1 Gene Promoter
DNA methylation pattern could be considered a biomarker to be exploited for the study and management of several human diseases. In this chapter,...
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Evolution and Diversity of DNA Methylation in Eukaryotes
DNA methylation (DNAm) is an important and well characterized epigenetic process which regulates gene expression, plays a vital role in embryonic...
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Genome-wide DNA methylation analysis in schizophrenia with tardive dyskinesia: a preliminary study
BackgroundTardive dyskinesia (TD) develops in 20–30% of schizophrenia patients and up to 50% in patients > 50 years old. DNA methylation may play an...
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DNA Methylation Analysis Using Bisulfite Pyrosequencing
Pyrosequencing is a DNA sequencing-by-synthesis technique that can quantitatively detect single-nucleotide polymorphisms (SNPs). With pyrosequencing,...
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Small RNA and DNA Methylation of Tea Plants
Small RNAs are a category of short noncoding RNAs (ncRNAs) with 18–30 nt lengths. Based on their function and mechanisms of biogenesis, these small...
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A Brief Introduction to Diet and DNA Methylation
Epigenetic regulatory mechanisms, which include DNA methylation, histone modifications, and non-coding RNA pathways, are independent of DNA sequence...
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Lipid Metabolism, Methylation Aberrant, and Osteoporosis: A Multi-omics Study Based on Mendelian Randomization
BackgroundObservational studies have shown a causal association between dyslipidemia and osteoporosis, but the genetic causation and complete...
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pycoMeth: a toolbox for differential methylation testing from Nanopore methylation calls
We present pycoMeth , a toolbox to store, manage and analyze DNA methylation calls from long-read sequencing data obtained using the Oxford Nanopore...
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Single-molecule long-read methylation profiling reveals regional DNA methylation regulated by Elongator Complex Subunit 2 in Arabidopsis roots experiencing spaceflight
BackgroundThe Advanced Plant Experiment-04 - Epigenetic Expression (APEX-04-EpEx) experiment onboard the International Space Station examined the...
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A case control study investigating the methylation levels of GHRL and GHSR genes in alcohol use disorder
BackgroundAlcohol use disorder (AUD) is a relapsing disease described as excessive use of alcohol. Evidence of the role of DNA methylation in...
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5-mC methylation study of sORFs in 3ˈUTR of transcription factor JUNGBRUNNEN 1-like during leaf rust pathogenesis in wheat
BackgroundJUB1, a NAC domain containing hydrogen peroxide-induced transcription factor, plays a critical role in plant immunity. Little is known...
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Global DNA methylation and miR-126-3p expression in Mexican women with gestational diabetes mellitus: a pilot study
BackgroundGestational diabetes mellitus (GDM), a type of diabetes that occurs for the first time during pregnancy, may predispose the development of...
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Interactive DNA Methylation Array Analysis with ShinyÉPICo
Arrays provide a cost-effective platform for the analysis of human DNA methylation. ShinyÉPICo is an interactive, web-based, and graphical tool that...