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Methylation-Specific Electrophoresis
Methylation of CpG sites in the promoter region of genomic DNA is an important epigenetic modification that plays a critical role in gene regulation,...
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DNA Methylation Profile of CD14+ Monocytes Changes in Primary Progressive Multiple Sclerosis
AbstractMultiple sclerosis (MS) is a chronic autoimmune inflammatory and neurodegenerative disease of the central nervous system, which is...
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Transcriptome-wide N6-methyladenosine methylation profile of atherosclerosis in mice
BackgroundAtherosclerosis (AS) is a critical pathological event during the progression of cardiovascular diseases. It exhibits fibrofatty lesions on...
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Phasing DNA Methylation
Haploty** enables the study of allele-specific events. Heterozygous variants, primarily single nucleotide variants (SNVs), enable the assignment of...
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Estimating genome-wide DNA methylation heterogeneity with methylation patterns
BackgroundIn a heterogeneous population of cells, individual cells can behave differently and respond variably to the environment. This cellular...
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pycoMeth: a toolbox for differential methylation testing from Nanopore methylation calls
We present pycoMeth , a toolbox to store, manage and analyze DNA methylation calls from long-read sequencing data obtained using the Oxford Nanopore...
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Global DNA methylation profile at LINE-1 repeats and promoter methylation of genes involved in DNA damage response and repair pathways in human peripheral blood mononuclear cells in response to Ī³-radiation
DNA methylation is an epigenetic mechanism, which plays an important role in gene regulation. The present study evaluated DNA methylation profile of...
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DNA methylation patterns of transcription factor binding regions characterize their functional and evolutionary contexts
BackgroundDNA methylation is an important epigenetic modification which has numerous roles in modulating genome function. Its levels are spatially...
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Targeted DNA Methylation in Mouse Early Embryos
In germ cell lines, including early preimplantation embryos, centromeres and pericentromeres are known to show a marked hypomethylation pattern...
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Bone Marrow Mesenchymal Stem Cells Reversed Ovarian Aging-related m6A RNA Methylation Modification Profile in Aged Granulosa Cells
BackgroundOvarian ageing causes endocrine disturbances and the degeneration of systemic tissue and organ functions to seriously affect women's...
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Inhibitors of DNA Methylation
DNA methylation is involved in numerous biological processes and is deregulated in human diseases. The modulation of the activity of the enzymes and...
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A supervised learning method for classifying methylation disorders
BackgroundDNA methylation is one of the most stable and well-characterized epigenetic alterations in humans. Accordingly, it has already found...
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DNA methylation in poultry: a review
As an important epigenetic modification, DNA methylation is involved in many biological processes such as animal cell differentiation, embryonic...
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An overview of DNA methylation-derived trait score methods and applications
Microarray technology has been used to measure genome-wide DNA methylation in thousands of individuals. These studies typically test the associations...
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Altered cfDNA fragmentation profile in hypomethylated regions as diagnostic markers in breast cancer
BackgroundBreast cancer, the most common malignancy in women worldwide, has been proven to have both altered plasma cell-free DNA (cfDNA) methylation...
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Drought induces DNA methylation balanceārelated genes in a stage-dependent manner during tomato fruit ripening
DNA methylation balance plays an important regulatory role in drought response and tolerance and also in the control of tomato fruit ripening, and...
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Hierarchical classification-based pan-cancer methylation analysis to classify primary cancer
Hierarchical classification offers a more specific categorization of data and breaks down large classification problems into subproblems, providing...
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Genome-Wide Young L1 Methylation Profiling by bs-ATLAS-seq
By silencing L1 retrotransposons, DNA methylation protects mammalian genomes from potent endogenous mutagens. However, some loci can escape this...
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Specific DNMT3C flanking sequence preferences facilitate methylation of young murine retrotransposons
The DNA methyltransferase DNMT3C appeared as a duplication of the DNMT3B gene in muroids and is required for silencing of young retrotransposons in...
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Universal DNA methylation age across mammalian tissues
Aging, often considered a result of random cellular damage, can be accurately estimated using DNA methylation profiles, the foundation of pan-tissue...
