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Metabolic Control Analysis
Metabolic Control Analysis (MCA) is a theoretical framework for investigating and understanding control and regulation of metabolism. In particular,...
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IPSC derived cardiac fibroblasts of DMD patients show compromised actin microfilaments, metabolic shift and pro-fibrotic phenotype
Duchenne muscular dystrophy (DMD) is a severe form of muscular dystrophy caused by mutations in the dystrophin gene. We characterized which isoforms...
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Metabolic phenotype analysis of Trichophyton rubrum after laser irradiation
BackgroundBiological phenotypes are important characteristics of microorganisms, and often reflect their genotype and genotype changes....
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Systems Biology for Metabolic Disorder and Disease
The simplistic approach frequently used in biological sciences is no longer sufficient if we want to research complicated multi-factorial illnesses...
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Prevention, Diagnosis, and Understanding Mechanisms of Metabolic Diseases Using Systems Biology
Human metabolic diseases are typically network diseases. These diseases including cardiovascular diseases (CVDs), type 2 diabetes (T2D), obesity,...
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Fluxomics and Metabolic Flux Analysis
Fluxomics and metabolic flux analysis (MFA) are cutting-edge experimental techniques in a biological system focuses on quantifying the flux of...
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The impact of autophagy modulation on phenotype and survival of cardiac stromal cells under metabolic stress
Cardiac stromal cells (CSCs) embrace multiple phenotypes and are a contributory factor in tissue homeostasis and repair. They can be exploited as...
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Left ventricular trabeculation in Hominidae: divergence of the human cardiac phenotype
Although the gross morphology of the heart is conserved across mammals, subtle interspecific variations exist in the cardiac phenotype, which may...
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Tea Plant Genomic, Transcriptomic, and Metabolic Databases
Tea plant, an important nonalcoholic beverage crop, is extensively cultivated worldwide. The exponential growth of biological sequence data has made...
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Persistence Phenotype
In the past few years, the persistence of foodborne pathogens in food processing units has drawn significant attention. Persistence involves those...
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Metabolic Adaptations and Functional Activity of Macrophages in Homeostasis and Inflammation
AbstractIn recent years, the role of cellular metabolism in immunity has come into the focus of many studies. These processes form a basis for the...
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The senescence-associated secretory phenotype and its physiological and pathological implications
Cellular senescence is a state of terminal growth arrest associated with the upregulation of different cell cycle inhibitors, mainly p16 and p21,...
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Siderophore-synthesizing NRPS reprogram lipid metabolic profiles for phenotype and function changes of Arthrobotrys oligospora
The objective of this paper is to explore the function of the AOL-s00215g415 ( Aog415 ) gene, which encodes for the synthesis of siderophore in the...
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Metabolic heterogeneity in cancer
Cancer cells rewire their metabolism to survive during cancer progression. In this context, tumour metabolic heterogeneity arises and develops in...
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Metabolic Engineering for Improving Vegetable Oils
Synthetic biology’s application to metabolic engineering allows the production of biomolecules of interest for applications for the chemical,...
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Metabolic regulation of RA macrophages is distinct from RA fibroblasts and blockade of glycolysis alleviates inflammatory phenotype in both cell types
Recent studies have shown the significance of metabolic reprogramming in immune and stromal cell function. Yet, the metabolic reconfiguration of RA...
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Effect of Junk Food on Hormonal and Metabolic Manifestations in Polycystic Ovarian Syndrome Phenotypes: A Case–Control Study of Kashmiri Population
Polycystic ovarian syndrome is the most common endocrinopathy with heterogeneous symptomatology and diverse etiological links. Apart from genetic...
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Role of liver sinusoidal endothelial cell in metabolic dysfunction-associated fatty liver disease
Liver sinusoidal endothelial cells (LSECs) are highly specialized endothelial cells that represent the interface between blood cells on one side and...
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Metabolic Heterogeneity of Tumors
Abstract —Currently, much attention in oncology is devoted to the issues of tumor heterogeneity, which creates serious problems in the diagnosis and...
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Biological characteristics and metabolic phenotypes of different anastomosis groups of Rhizoctonia solani strains
BackgroundRhizoctonia solani is an important plant pathogen worldwide, and causes serious tobacco target spot in tobacco in the last five years....
