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Neonatal Cardiac Mesenchymal Stromal Cells Promote Recovery of Infarcted Myocardium through CD44 Mediated FoxP3+ T-Regulatory Cells after Vascular Infusion
AbstractIntravenous infusion has been used as the method of cell delivery in many preclinical studies as well as in some early clinical trials. Among...
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Mesenchymal/stromal stem cells: necessary factors in tumour progression
Mesenchymal/stromal stem cells (MSCs) are a crucial component of the tumour microenvironment (TME). They can be recruited from normal tissues into...
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Estrogen- and Progesterone (P4)-Mediated Epigenetic Modifications of Endometrial Stromal Cells (EnSCs) and/or Mesenchymal Stem/Stromal Cells (MSCs) in the Etiopathogenesis of Endometriosis
Endometriosis is a common chronic inflammatory condition in which endometrial tissue appears outside the uterine cavity. Because ectopic...
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Single-cell analysis reveals the stromal dynamics and tumor-specific characteristics in the microenvironment of ovarian cancer
High-grade serous ovarian carcinoma (HGSOC) is a heterogeneous disease, and a highstromal/desmoplastic tumor microenvironment (TME) is associated...
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New dawn for keratoconus treatment: potential strategies for corneal stromal regeneration
Keratoconus is a progressive, ectatic and blinding disorder of the cornea, characterized by thinning of corneal stroma. As a highly...
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Understanding crosstalk of organ tropism, tumor microenvironment and noncoding RNAs in breast cancer metastasis
Cancer metastasis is one of the major clinical challenges worldwide due to limited existing effective treatments. Metastasis roots from the host...
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Patient-derived xenografts as compatible models for precision oncology
Cancer is a very heterogeneous disease, displaying heterogeneity between patients (inter-tumoral heterogeneity) and heterogeneity within a patient...
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Amniotic Fluid Stem Cell Populations
Amniotic fluid can be considered not only a precious source of information about the develo** embryo/fetus, but also a reservoir of potentially...
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The ins and outs of muscle stem cell aging
Skeletal muscle has a remarkable capacity to regenerate by virtue of its resident stem cells (satellite cells). This capacity declines with aging,...
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The effect of gestational diabetes on proliferation capacity and viability of human umbilical cord-derived stromal cells
Stomal cells derived from Wharton’s jelly of human umbilical cord (WJMSCs) are considered as the potential therapeutic agents for regeneration and...
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Adult Human Corneal Epithelial Stem Cells
The cornea’s accessibility and visualization with minimally invasive techniques renders it an ideal organ to study SC and their differentiated...
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Investigating prostate cancer tumour-stroma interactions - clinical and biological insights from an evolutionary game
Background:Tumours are made up of a mixed population of different types of cells that include normal structures as well as ones associated with the...
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Stem Cell Delivery Methods and Routes
A long-held tenet of cell therapies has been that a biologically relevant dose of cells must be delivered to the site of injury and at least...
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Gene expression pattern of functional neuronal cells derived from human bone marrow mesenchymal stromal cells
BackgroundNeuronal tissue has limited potential to self-renew or repair after neurological diseases. Cellular therapies using stem cells are...
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Engineering the In Vitro Cellular Microenvironment for the Control and Manipulation of Adult Stem Cell Responses
Stem cells have generated a great deal of excitement as a potential source of cells for transplantation because of their ability to self-renew and...
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Function of the Neuropeptide Head Activator for Early Neural and Neuroendocrine Development
Head activator (HA) is an undecapeptide (Fig. 1) identical in sequence from hydra to mammals (Bodenmüller and Schaller 1981; Schaller and Bodenmüller...
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Age-Related Changes in the Expression of Cadherin-11, the Mesenchyme Specific Calcium-Dependent Cell Adhesion Molecule
Cadherin-11 is a calcium-dependent cell adhesion molecule that is expressed in cells of the mesenchymal lineage during embryonic development. In...
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Enhanced growth of canine bone marrow stromal cell cultures in the presence of acidic fibroblast growth factor and heparin
The ex vivo establishment, expansion, transduction, and reintroduction of autologous bone marrow stromal cells offers a potential efficacious system...
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The Role of Stromal-Epithelial Interactions in the Regulation of Growth and Differentiation in Adult Epithelial Cells
There is general agreement that paracrine influences are of paramount importance during embryonic and fetal life. From studies on amphibians it has...