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Overview of the compromised mucosal integrity in celiac disease
Intestinal epithelium is a dynamic cellular layer that lines the small-bowel and makes a relatively impenetrable barrier to macromolecules....
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Mechanical Harvesting
Mechanical harvest of tree fruit and grapes involves a number of nearly endless, as well as highly variable, factors and challenges, much in part due...
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The interplay between cell wall integrity and cell cycle progression in plants
Plant cell walls are dynamic structures that play crucial roles in growth, development, and stress responses. Despite our growing understanding of...
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RALF signaling pathway activates MLO calcium channels to maintain pollen tube integrity
Pollen tube tip growth requires intricate Ca 2+ signaling. Recent studies have also identified rapid alkalization factor (RALF)-family peptides and...
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Age-dependent loss of HAPLN1 erodes vascular integrity via indirect upregulation of endothelial ICAM1 in melanoma
Melanoma, the most lethal form of skin cancer, often has worse outcomes in older patients. We previously demonstrated that an age-related decrease in...
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Theoretical and Methodological Substantiation of Boundaries and Integrity in Landscape Cover and Its Components
AbstractFour main models of the appearance of boundaries (in a particular case, integrity), arising from the theory of nonlinear dynamic systems, are...
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Cell wall integrity regulation across plant species
Plant cell walls are highly dynamic and chemically complex structures surrounding all plant cells. They provide structural support, protection from...
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Mechanical Actuation of Organoids in Synthetic Microenvironments
Organoids are a powerful model system to explore the role of mechanical forces in sculpting emergent tissue cytoarchitecture. The modulation of the...
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Activation of the cell wall integrity pathway negatively regulates TORC2-Ypk1/2 signaling through blocking eisosome disassembly in Saccharomyces cerevisiae
The target of rapamycin complex 2 (TORC2) signaling is associated with plasma membrane (PM) integrity. In Saccharomyces cerevisiae , TORC2-Ypk1/2...
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Cultured Pig Thyroid Follicular Cells: Electrical Evaluation of Epithelial Integrity
Thyroid epithelial cells organize as enclosed follicles containing thyroid hormone precursor, iodinated thyroglobulin, with lumina bordered by the...
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Mechanical state transitions in the regulation of tissue form and function
From embryonic development, postnatal growth and adult homeostasis to reparative and disease states, cells and tissues undergo constant changes in...
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A human proteogenomic-cellular framework identifies KIF5A as a modulator of astrocyte process integrity with relevance to ALS
Genome-wide association studies identified several disease-causing mutations in neurodegenerative diseases, including amyotrophic lateral sclerosis...
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Loss of miR-101-3p in melanoma stabilizes genomic integrity, leading to cell death prevention
Malignant melanoma remains the most lethal form of skin cancer, exhibiting poor prognosis after forming distant metastasis. Owing to their potential...
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Dynamics of pectic homogalacturonan in cellular morphogenesis and adhesion, wall integrity sensing and plant development
Homogalacturonan (HG) is the most abundant pectin subtype in plant cell walls. Although it is a linear homopolymer, its modification states allow for...
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P4-ATPase subunit Cdc50 plays a role in yeast budding and cell wall integrity in Candida glabrata
BackgroundAs highly-conserved types of lipid flippases among fungi, P4-ATPases play a significant role in various cellular processes. Cdc50 acts as...
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CTCF–CTCF loops and intra-TAD interactions show differential dependence on cohesin ring integrity
The ring-like cohesin complex mediates sister-chromatid cohesion by encircling pairs of sister chromatids. Cohesin also extrudes loops along...
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Mechanical disengagement of the cohesin ring
Cohesin forms a proteinaceous ring that is thought to link sister chromatids by entrap** DNA and counteracting the forces generated by the mitotic...
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Mechanical Considerations of Myocardial Tissue and Cardiac Regeneration
Over the past decades, huge scientific efforts have been put into cardiac regeneration strategies. Although several strategies have been accepted for...
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Aflatoxin M1 decreases the expression of genes encoding tight junction proteins and influences the intestinal epithelial integrity
Aflatoxin M1 (AFM1) is a mycotoxin that is commonly found as a milk contaminant, and its presence in milk has been linked to cytotoxicity. The...
