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Targeted deletion of HAI-1 increases prostasin proteolysis but decreases matriptase proteolysis in human keratinocytes
Epidermal differentiation and barrier function require well-controlled matriptase and prostasin proteolysis, in which the Kunitz-type serine protease...
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Mild acidity likely accelerates the physiological matriptase autoactivation process: a comparative study between spontaneous and acid-induced matriptase zymogen activation
The pathophysiological functions of matriptase, a type 2 transmembrane serine protease, rely primarily on its enzymatic activity, which is under...
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The spatiotemporal control of human matriptase action on its physiological substrates: a case against a direct role for matriptase proteolytic activity in profilaggrin processing and desquamation
Studies of human genetic disorders and animal models indicate that matriptase plays essential roles in proteolytic processes associated with...
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Matriptase and prostasin proteolytic activities are differentially regulated in normal and wounded skin
Orchestrated control of multiple overlap** and sequential processes is required for the maintenance of epidermal homeostasis and the response to...
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HAI-1 is required for the novel role of FGFBP1 in maintenance of cell morphology and F-actin rearrangement in human keratinocytes
Formation and maintenance of skin barrier function require tightly controlled membrane-associated proteolysis, in which the integral membrane...
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Expression of genes related to iron homeostasis in breast cancer
BackgroundThe dysfunctions in the metabolism of iron have an important role in many pathological conditions, ranging from disease with iron...
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The difference in the intracellular Arg/Lys-rich and EHLVY motifs contributes to distinct subcellular distribution of HAI-1 versus HAI-2
The integral membrane, Kunitz-type, serine protease inhibitors, HAI-1 and HAI-2, closely resemble one another structurally and with regard to their...
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Peptidomimetic inhibitors of TMPRSS2 block SARS-CoV-2 infection in cell culture
The transmembrane serine protease 2 (TMPRSS2) primes the SARS-CoV-2 Spike (S) protein for host cell entry and represents a promising target for...
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An investigation of the relationship between TMPRSS6 gene expression, genetic variants and clinical findings in breast cancer
Breast cancer is one of the most common types of cancer among women worldwide. The TMPRSS6 (Transmembrane Serine Protease 6) gene encodes...
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Inhibition of autocrine HGF maturation overcomes cetuximab resistance in colorectal cancer
Although amplifications and mutations in receptor tyrosine kinases (RTKs) act as bona fide oncogenes, in most cancers, RTKs maintain moderate...
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Yeast Surface Display: New Opportunities for a Time-Tested Protein Engineering System
Yeast surface display has proven to be a powerful tool for the discovery of antibodies and other novel binding proteins and for engineering the...
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Possible role of combined therapy targeting MET and pro-HGF activation for renal cell carcinoma: analysis by human HGF-producing SCID mice
MET is a high-affinity receptor tyrosine kinase of HGF (hepatocyte growth factor). HGF is secreted as an inactive single-chain precursor (pro-HGF),...
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Recombinant therapeutic proteins degradation and overcoming strategies in CHO cells
AbstractMammalian cell lines are frequently used as the preferred host cells for producing recombinant therapeutic proteins (RTPs) having...
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Iron Metabolism, Calcium, Magnesium and Trace Elements: A Review
Iron (Fe) is fundamental to life on earth. In the human body, it is both essential and harmful if above threshold. A similar balance applies to other...
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In-depth proteome characterization of endometrium and extraembryonic membranes during implantation in pig
BackgroundProteome characterization of the porcine endometrium and extraembryonic membranes is important to understand mother-embryo...
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Matriptase zymogen supports epithelial development, homeostasis and regeneration
BackgroundMatriptase is a membrane serine protease essential for epithelial development, homeostasis, and regeneration, as well as a central...
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Deletion of 11q24.2-qter in a male child with cleft lip and palate: an atypical feature of Jacobsen syndrome
Jacobsen syndrome (JS) is caused by the terminal deletion at the long arm of chromosome 11. It is characterized by growth retardation, intellectual...
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CD146, a therapeutic target involved in cell plasticity
Since its identification as a marker for advanced melanoma in the 1980s, CD146 has been found to have multiple functions in both physiological and...
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Serine protease PRSS56, a novel cancer-testis antigen activated by DNA hypomethylation, promotes colorectal and gastric cancer progression via PI3K/AKT axis
BackgroundCancer/testis (CT) antigens/genes are usually overexpressed in cancers and exhibit high immunogenicity, making them promising targets for...
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Hepatocyte growth factor activator inhibitor-2 stabilizes Epcam and maintains epithelial organization in the mouse intestine
Mutations in SPINT2 encoding the epithelial serine protease inhibitor hepatocyte growth factor activator inhibitor-2 (HAI-2) are associated with...
