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X-Ray Crystallography for Macromolecular Complexes
X-ray crystallography has for most of the last century been the standard technique to determine the high-resolution structure of biological...
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Determining Macromolecular Structures Using Cryo-Electron Microscopy
Structural insights into macromolecular and protein complexes provide key clues about the molecular basis of the function. Cryogenic electron...
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Determining Protein Structures Using X-Ray Crystallography
X-ray crystallography is a robust and widely used technique that facilitates the three-dimensional structure determination of proteins at an atomic...
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Revisiting macromolecular hydration with HullRadSAS
Hydration of biological macromolecules is important for their stability and function. Historically, attempts have been made to describe the degree of...
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Pre- and Post-publication Verification for Reproducible Data Mining in Macromolecular Crystallography
Like an article narrative is deemed by an editor and referees to be worthy of being a version of record on acceptance as a publication, so must the...
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Preparation of RNA Microcrystals for Serial Femtosecond Crystallography Experiments
Serial femtosecond crystallography (SFX) experiments using an X-ray free electron laser (XFEL) is a burgeoning method for time-resolved structural...
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Mix-and-Inject Serial Femtosecond Crystallography to Capture RNA Riboswitch Intermediates
Time-resolved structure determination of macromolecular conformations and ligand-bound intermediates is extremely challenging, particularly for RNA....
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Macromolecular Protein Complexes IV Structure and Function
This book covers the latest findings of a wide variety of viral, prokaryotic and eukaryotic macromolecular protein complexes and builds upon the...
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Macromolecular Protein Complexes V Structure and Function
This volume in the Subcellular Biochemistry (SCBI) series is a continuation of several previous volumes devoted to the structural and functional...
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Sample Preparation for Electron Cryo-Microscopy of Macromolecular Machines
High-resolution structure determination by electron cryo-microscopy underwent a step change in recent years. This now allows study of challenging...
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Perfect Crystals: microgravity capillary counterdiffusion crystallization of human manganese superoxide dismutase for neutron crystallography
The NASA mission Perfect Crystals used the microgravity environment on the International Space Station (ISS) to grow crystals of human manganese...
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Biophysical Reviews’ “meet the editors series”—a profile of Steve Harding’s career in macromolecular hydrodynamics
Stephen Harding, Director of the National Centre for Macromolecular Hydrodynamics based in the UK, is invited to introduce himself as a new Executive...
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Integrative structural modeling of macromolecular complexes using Assembline
Integrative modeling enables structure determination of macromolecular complexes by combining data from multiple experimental sources such as X-ray...
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Macromolecular conformational changes in photosystem II: interaction between structure and function
Conformational changes play an important role in the functioning of proteins and their complexes. This is also true for the pigment-protein...
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A comprehensive approach to phytochemical analysis of macromolecular composites that protect tubers: case studies in suberized potato periderm tissues
Terrestrial plants rely on protection conferred by their outer coverings to defend against desiccation, bruising, and microbial invasion. For food...
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Ab initio phasing macromolecular structures using electron-counted MicroED data
Structures of two globular proteins were determined ab initio using microcrystal electron diffraction (MicroED) data that were collected on a direct...
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Structure Determination of SH2–Phosphopeptide Complexes by X-Ray Crystallography: The Example of p120RasGAP
The p120RasGAP protein contains two Src homology 2 (SH2) domainsSrc-homology 2 (SH2) domain, each with phosphotyrosine-binding activity. We describe...