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Macrolide resistance among Streptococcus agalactiae during COVID-19 public health emergency in Brazil
During COVID-19 public health emergence, azithromycin was excessively used in Brazil, as part of a controversial “early treatment”, recommended by...
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The global distribution of the macrolide esterase EstX from the alpha/beta hydrolase superfamily
Macrolide antibiotics, pivotal in clinical therapeutics, are confronting resistance challenges mediated by enzymes like macrolide esterases, which...
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Human enterococcal isolates as reservoirs for macrolide-lincosamide-streptogramin and other resistance genes
According to recent studies, the importance of MLS (macrolide-lincosamide-streptogramin) resistance phenotypes and genes in enterococci are reflected...
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Gene expression profile of Campylobacter jejuni in response to macrolide antibiotics
Campylobacter jejuni is a foodborne pathogen that causes gastroenteritis in humans and has developed resistance to various antibiotics. The primary...
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A combination strategy of a semisynthetic macrolide, 5-O-mycaminosyltylonolide with polymyxin B nonapeptide for multi-drug resistance P. aeruginosa
The emergence and spread of antimicrobial resistant pathogens continue to threaten our ability to combat several infections. Among them, Pseudomonas...
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An efflux pump deletion mutant enabling the discovery of a macrolide as an overlooked anti-P. aeruginosa active compound
Antimicrobial resistance is a serious, worldwide problem. Pseudomonas aeruginosa ( P. aeruginosa ) is the pathogen that poses a major threat to human...
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Quantitative proteomics analysis of Mycoplasma pneumoniae identifies potential macrolide resistance determinants
Mycoplasma pneumoniae is one of the leading causes of community-acquired pneumonia in children and adolescents. Because of the wide application of...
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Nucleotide methylations in rRNA that confer resistance to ribosome-targeting antibiotics
Methylation of rRNA nucleotides is an effective means of conferring resistance to antibiotics that target the bacterial ribosome. This type of...
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Profile and resistance levels of 136 integron resistance genes
Integrons have played a major role in the rise and spread of multidrug resistance in Gram-negative pathogens and are nowadays commonplace among...
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Bacteria exposed to antiviral drugs develop antibiotic cross-resistance and unique resistance profiles
Antiviral drugs are used globally as treatment and prophylaxis for long-term and acute viral infections. Even though antivirals also have been shown...
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Genetic diversity of macrolides resistant Staphylococcus aureus clinical isolates and the potential synergistic effect of vitamins, C and K3
BackgroundMacrolide antibiotics have been extensively used for the treatment of Staphylococcus aureus infections. However, the emergence of...
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Antimicrobial treatment and resistance in sexually transmitted bacterial infections
Sexually transmitted infections (STIs) have been part of human life since ancient times, and their symptoms affect quality of life, and sequelae are...
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Campylobacter jejuni and Campylobacter coli in human stool samples: antibiotic resistance profiles, putative virulence determinants and molecular characterization of the isolates
Campylobacters, especially C. jejuni and C. coli, have become one of the leading causes of acute gastroenteritis in humans worldwide in recent years....
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Phenotypic and Genotypic Characterization of Antimicrobial Resistance in Streptococci Isolated from Human and Animal Clinical Specimens
Recently, the phenomenon of infection of humans as hosts by animal pathogens has been increasing. Streptococcus is an example of a genus in which...
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Occurrence of antibiotics and bacterial resistance genes in wastewater: resistance mechanisms and antimicrobial resistance control approaches
Antimicrobial pharmaceuticals are classified as emergent micropollutants of concern, implying that even at low concentrations, long-term exposure to...
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Tracking Antibiotic Resistance from the Environment to Human Health
Antimicrobial resistance (AMR) is one of the threats to our world according to the World Health Organization (WHO). Resistance is an evolutionary...
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Functionally distinct mutations within AcrB underpin antibiotic resistance in different lifestyles
Antibiotic resistance is a pressing healthcare challenge and is mediated by various mechanisms, including the active export of drugs via multidrug...
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Decoding antimicrobial resistance: unraveling molecular mechanisms and targeted strategies
Antimicrobial resistance poses a significant global health threat, necessitating innovative approaches for combatting it. This review explores...
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Extensive screening reveals previously undiscovered aminoglycoside resistance genes in human pathogens
Antibiotic resistance is a growing threat to human health, caused in part by pathogens accumulating antibiotic resistance genes (ARGs) through...
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Occurrence and Health Risks of Antibiotic Resistance in African Aquatic Systems
Antibiotic resistance is an emerging global health concern that has attracted significant attention. Recently, antibiotic resistance has been...