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Alterations in global DNA methylation and metabolism-related genes caused by zearalenone in MCF7 and MCF10F cells
Zearalenone (ZEN) is a non-steroidal estrogenic mycotoxin produced by Fusarium fungi. ZEN has endocrine disruptor effects and could impair the...
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Oestrogen receptor-independent actions of oestrogen in cancer
Oestrogen, the primary female sex hormone, plays a significant role in tumourigenesis. The major pathway for oestrogen is via binding to its receptor...
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Cellular and micro-environmental responses influencing the antitumor activity of all-trans retinoic acid in breast cancer
All-trans retinoic acid ( ATRA ) is the most relevant and functionally active metabolite of Vitamin-A . From a therapeutic standpoint, ATRA is the first...
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An In Vitro Model of Triple-Negative Breast Cancer
We have characterized two highly tumorigenic and metastatic basal B TNBC cell lines, XtMCF and LmMCF, with the additional values of having the normal... -
CRL4DCAF8 dependent opposing stability control over the chromatin remodeler LSH orchestrates epigenetic dynamics in ferroptosis
Despite the emerging evidence on ferroptosis implicated in diverse pathologies, molecular linkage between oxidative inducers and chromatin as...
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Resveratrol and its methoxy derivatives modulate the expression of estrogen metabolism enzymes in breast epithelial cells by AhR down-regulation
Our earlier studies have shown that compared to resveratrol, its analogs with ortho -methoxy substituents exert stronger antiproliferative and...
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Oxidized derivative of docosahexaenoic acid preferentially inhibit cell proliferation in triple negative over luminal breast cancer cells
Omega-3 polyunsaturated fatty acids (PUFAs) exert an anticancer effect by affecting multiple cellular mechanisms leading to inhibition of...
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The Role of the Basal Stem Cell of the Human Breast in Normal Development and Cancer
MCF-10F, an ERα negative human breast epithelial cell line derived from normal breast tissue, is able to form ductal structures in a tridimensional... -
Regulation of CEACAM1 transcription in human breast epithelial cells
BackgroundCarcinoembryonic antigen cell adhesion molecule 1 (CEACAM1) is a transmembrane protein with multiple functions in different cell types....
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Cell–Cell Adhesion Molecule CEACAM1 is Expressed in Normal Breast and Milk and Associates with β1 Integrin in a 3D Model of Morphogenesis
CEA cell adhesion molecule-1 (CEACAM1) is a cell–cell adhesion molecule that, paradoxically, is expressed in an apical location in normal breast...