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The New Frontier of Three-Dimensional Culture Models to Scale-Up Cancer Research
In vitro cancer research models require the utmost accuracy and precision to effectively investigate physiological pathways and mechanisms, as well...
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Identification of novel QTLs for salt tolerance in zombi pea (Vigna vexillata)
Soil salinity is a major abiotic stress in agricultural production, as it hampers the growth and development of crop plants. Develo** crop...
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Shining the spotlight on the neglected: new high-quality genome assemblies as a gateway to understanding the evolution of Trypanosomatidae
BackgroundProtists of the family Trypanosomatidae (phylum Euglenozoa) have gained notoriety as parasites affecting humans, domestic animals, and...
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Advanced Enzyme Immobilization Technologies: An Eco-friendly Support, a Polymer-Stabilizing Immobilization Strategy, and an Improved Cofactor Co-immobilization Technique
There is a wide variety of protocols for enzyme immobilization, allowing for the reuse of the enzyme, integration in flow bioreactors, and easy...
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A reproducible scaffold-free 3D organoid model to study neoplastic progression in breast cancer
While 3D cellular models are useful to study biological processes, gel-embedded organoids have large variability. This paper describes high-yield...
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Unveiling the relationship between WWOX and BRCA1 in mammary tumorigenicity and in DNA repair pathway selection
Breast cancer is the leading cause of cancer-related deaths in women worldwide, with the basal-like or triple-negative breast cancer (TNBC) subtype...
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Antibody and antibody fragments site-specific conjugation using new Q-tag substrate of bacterial transglutaminase
During the last few years Antibody-Drug Conjugates (ADCs) have become one of the most active and very promising therapeutic weapons. Lessons learned...
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A novel sterol glycosyltransferase catalyses steroidal sapogenin 3-O glucosylation from Paris polyphylla var. yunnanensis
BackgroundParis polyphylla var. yunnanensis is an important medicinal plant, and the main active ingredient of the plant is polyphyllin, which is a...
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Gold Nanoparticle-Based Colorimetric Sensing of Metal Toxins
Miniaturized sensing devices have emerged as prevailing micro-scale analysis devices in the past few decades. In this context, metal...
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Filamentous morphology of bacterial pathogens: regulatory factors and control strategies
AbstractSeveral studies have demonstrated that when exposed to physical, chemical, and biological stresses in the environment, many bacteria...
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High contiguity de novo genome assembly and DNA modification analyses for the fungus fly, Sciara coprophila, using single-molecule sequencing
BackgroundThe lower Dipteran fungus fly, Sciara coprophila , has many unique biological features that challenge the rule of genome DNA constancy. For...
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Characterisation of a solvent-tolerant haloarchaeal (R)-selective transaminase isolated from a Triassic period salt mine
Transaminase enzymes (TAms) are becoming increasingly valuable in the chemist’s toolbox as a biocatalytic route to chiral amines. Despite high...
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Genomics
Plant breeding research has historically progressed due to unintentional selection following crop development and the desire for increased food...
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Kaiso (ZBTB33) subcellular partitioning functionally links LC3A/B, the tumor microenvironment, and breast cancer survival
The use of digital pathology for the histomorphologic profiling of pathological specimens is expanding the precision and specificity of quantitative...
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Secreted midbody remnants are a class of extracellular vesicles molecularly distinct from exosomes and microparticles
During the final stages of cell division, newly-formed daughter cells remain connected by a thin intercellular bridge containing the midbody (MB), a...
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Targeted cancer cell delivery of arsenate as a reductively activated prodrug
AbstractNanoformulations, prodrugs, and targeted therapies are among the most intensively investigated approaches to new cancer therapeutics. Human...
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Recent progress in microRNA-based delivery systems for the treatment of human disease
MicroRNAs (miRNAs) are naturally occurring, small non-coding RNAs that mediate posttranscriptional regulation. Based on the level of sequence...
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Models for Monocytic Cells in the Tumor Microenvironment
Monocytes (Mos) are immune cells that critically regulate cancer, enabling tumor growth and modulating metastasis. Mos can give rise to...
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The mechanisms of action of prenylated xanthones against breast, colon, and lung cancers, and their potential application against drug resistance
Cancers such as breast, colon, and lung cancers are among the leading causes of death with alarming increases in the number of new diagnoses and...
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A comprehensive overview of cotton genomics, biotechnology and molecular biological studies
Cotton is an irreplaceable economic crop currently domesticated in the human world for its extremely elongated fiber cells specialized in seed...