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Genome-wide identification and mining elite allele variation of the Monoacylglycerol lipase (MAGL) gene family in upland cotton (Gossypium hirsutum L.)
BackgroundMonoacylglycerol lipase ( MAGL ) genes belong to the alpha/beta hydrolase superfamily, catalyze the terminal step of triglyceride (TAG)...
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Assay of Monoacylglycerol Lipase Activity
Monoacylglycerol lipase (MGL/MAGL/MGLL) is a serine hydrolase involved in the biological deactivation of the endocannabinoid...
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The impact of medicinal plant Ocimum minimum L. on fatty acid synthesis process in breast cancer cells
Breast cancer is the most diagnosed invasive cancer and the second leading cause of cancer in women. Standard medicinal protocol for treatment of...
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JZL184, A Monoacylglycerol Lipase Inhibitor, Induces Bone Loss in a Multiple Myeloma Model of Immunocompetent Mice
Multiple myeloma (MM) patients develop osteolysis characterised by excessive osteoclastic bone destruction and lack of osteoblast bone formation....
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Endocannabinoid Metabolism and Transport as Drug Targets
The wide distribution of the endocannabinoid system (ECS) throughout the body and its pivotal pathophysiological role offer promising opportunities...
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Are lipid droplets the picnic basket of brain tumours?
Are lipid droplets (LDs) necessary to maintain the viability of brain tumour cells as they move to new nutrient-poor environments? In turn, could...
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Machine Learning and Computational Chemistry for the Endocannabinoid System
Computational methods in medicinal chemistry facilitate drug discovery and design. In particular, machine learning methodologies have recently gained...
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Early endocannabinoid-mediated depolarization-induced suppression of excitation delays the appearance of the epileptic phenotype in synapsin II knockout mice
The mechanism underlying the transition from the pre-symptomatic to the symptomatic state is a crucial aspect of epileptogenesis. SYN2 is a member of...
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Need for Methods to Investigate Endocannabinoid Signaling
Endocannabinoids (eCBs) are endogenous lipids able to bind to cannabinoid receptors, the primary molecular targets of the cannabis (Cannabis sativa)...
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Assay of Endocannabinoid Uptake
Endocannabinoids at nanomolar physiological concentrations cross cellular membranes by facilitated diffusion, a process that can be studied by...
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The impact of lipid metabolism on breast cancer: a review about its role in tumorigenesis and immune escape
BackgroundBreast cancer (BC) is the second most frequent type of cancer in the world and most common among women, configuring a major challenge to...
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Antiviral Activities of Cannabis
Despite the history of scientific evidence regarding plants and their products in prophylactics and therapeutics, their applications in healthcare...
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Electrophysiology of Endocannabinoid Signaling
Electrophysiological technique is an efficient tool for investigating the synaptic regulatory effects mediated by the endocannabinoid system....
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The Analgesic Effects of Cannabis
Drugs derived from Cannabis were used until the 1940s for their stimulant and depressant effects in treating somatic and psychiatric illnesses....
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The CB1 cannabinoid receptor regulates autophagy in the tibialis anterior skeletal muscle in mice
The endocannabinoid system (ECS) regulates energy metabolism, has been implicated in the pathogenesis of metabolic diseases and exerts its actions...
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Cannabinoids and healthy ageing: the potential for extending healthspan and lifespan in preclinical models with an emphasis on Caenorhabditis elegans
There is a significant global upsurge in the number and proportion of older persons in the population. With this comes an increasing prevalence of...
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Molecular Findings Guiding the Modulation of the Endocannabinoid System as a Potential Target to Treat Schizophrenia
Schizophrenia is a psychiatric disorder of neurodevelopmental origin that is thought to result from the combination of genetic and socioenvironmental...
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The Bioactive Components of Cannabis
Cannabinoids (CBDs) represent a group of C21 or C22 terpenophenolic compounds predominantly produced by Cannabis but have also been found in plants...
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Hypothalamic endocannabinoids in obesity: an old story with new challenges
The crucial role of the hypothalamus in the pathogenesis of obesity is widely recognized, while the precise molecular and cellular mechanisms...
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Association between diabetes and cancer. Current mechanistic insights into the association and future challenges
Compelling pieces of epidemiological, clinical, and experimental research have demonstrated that Diabetes mellitus (DM) is a major risk factor...
