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Regulation of urea cycle by reversible high-stoichiometry lysine succinylation
The post-translational modification lysine succinylation is implicated in the regulation of various metabolic pathways. However, its biological...
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Delivery of mRNA with Histidine-Lysine Peptides
Transfection with mRNA has been considered superior to that with plasmids since the mRNA can be translated to a protein in the cytosol without...
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Lysine-specific methyltransferase Set7/9 in stemness, differentiation, and development
The enzymes performing protein post-translational modifications (PTMs) form a critical post-translational regulatory circuitry that orchestrates...
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Shuttle between arginine and lysine: influence on cancer immunonutrition
Amino acids which are essential nutrients for all cell types’ survival are also recognised to serve as opportunistic/alternative fuels in cancers...
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Lysine deserts prevent adventitious ubiquitylation of ubiquitin-proteasome components
In terms of its relative frequency, lysine is a common amino acid in the human proteome. However, by bioinformatics we find hundreds of proteins that...
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Structural characterization of protein-material interfacial interactions using lysine reactivity profiling-mass spectrometry
Understanding how proteins and materials interact is useful for evaluating the safety of biomedical micro/nanomaterials, toxicity estimation and...
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Genetic code expansion reveals aminoacylated lysine ubiquitination mediated by UBE2W
Protein post-translational modification (PTM) regulates nearly every aspect of cellular processes in eukaryotes. However, the identification of new...
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The mechanisms, regulations, and functions of histone lysine crotonylation
Histone lysine crotonylation (Kcr) is a new acylation modification first discovered in 2011, which has important biological significance for gene...
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Lysine butyrylation of HSP90 regulated by KAT8 and HDAC11 confers chemoresistance
Posttranslational modification dramatically enhances protein complexity, but the function and precise mechanism of novel lysine acylation...
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Inadequate lysine content of wheat endosperm proteins - possibility of correcting it by CRISPR-Cas system of genome editing
Proteins in endosperms of mature wheat seeds contain ~ 2.5% lysine. Proteins in endosperms of immature wheat seeds after 8 days of anthesis,...
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Lysine acetylation of histone acetyltransferase adaptor protein ADA2 is a mechanism of metabolic control of chromatin modification in plants
Histone acetylation is a predominant active chromatin mark deposited by histone acetyltransferases (HATs) that transfer the acetyl group from acetyl...
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Glyoxal-derived advanced glycation end-products, Nε-carboxymethyl-lysine, and glyoxal-derived lysine dimer induce apoptosis-related gene expression in hepatocytes
BackgroundAdvanced glycation end-products (AGEs) are proteins or lipids that have been glycated nonenzymatically by reducing sugars and their...
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A Study of the Influence of L-Lysine and its Transporter LysP on the Characteristics of the L-Threonine Producer Strain
In this work, it was shown for the first time that inactivation of the L-lysine uptake transport system from the external environment leads to an...
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Metabolic Regulation of Lysine Acetylation: Implications in Cancer
Lysine acetylation is the second most well-studied post-translational modification after phosphorylation. While phosphorylation regulates signaling...
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PHOTOTROPIN1 lysine 526 functions to enhance phototropism in Arabidopsis
Main conclusionAfter blue-light exposure, ubiquitination of PHOTOTROPIN1 lysine 526 enhances phototropic responses.
AbstractArabidopsis blue-light...
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Lysine 2-hydroxyisobutyrylation of NAT10 promotes cancer metastasis in an ac4C-dependent manner
Posttranslational modifications add tremendous complexity to proteomes; however, gaps remain in knowledge regarding the function and regulatory...
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Exploring the Potential of Designed Peptides Containing Lysine and Arginine Repeats against VIM-2 Metallo-Beta-Lactamases
The persistent development of bacterial resistance to β-lactam antibiotics presents a serious risk to public health worldwide. The ability of...
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Solid-state fermentation production of L-lysine by Corynebacterium glutamicum (ATCC 13032) using agricultural by-products as substrate
To meet the growing demand for L-lysine, an essential amino acid with various applications, it is crucial to produce it on a large scale locally...
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Lysine methyltransferase SMYD2 inhibits antiviral innate immunity by promoting IRF3 dephosphorylation
Phosphorylation of IRF3 is critical to induce type I interferon (IFN-I) production in antiviral innate response. Here we report that lysine...
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Production performance, protein digestibility, gut health and economic efficiency in sexed broilers with super dozing of lysine
Modern commercial broiler is growing very rapidly and its amino acid requirement is not fulfilling. An experimental trial was conducted to study the...