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Engineering and Modeling the Lung Mesenchyme
The structure of the mammalian lung controls the flow of air through the airways and into the distal alveolar region where gas exchange occurs....
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Mesenchyme-derived vertebrate lonesome kinase controls lung organogenesis by altering the matrisome
Vertebrate lonesome kinase (VLK) is the only known secreted tyrosine kinase and responsible for the phosphorylation of a broad range of secretory...
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Reciprocal Interactions Between the Epithelium and Mesenchyme in Organogenesis
Many organs are composed of epithelial and mesenchymal tissue components. These two tissue component types develop via reciprocal interactions....
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A distal lung organoid model to study interstitial lung disease, viral infection and human lung development
Organoids have been an exciting advancement in stem cell research. Here we describe a strategy for directed differentiation of human pluripotent stem...
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Directed differentiation of human pluripotent stem cells into diverse organ-specific mesenchyme of the digestive and respiratory systems
Development of visceral organs such as the esophagus, lung, liver and stomach are coordinated by reciprocal signaling interactions between the...
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An Introduction to Engineering and Modeling the Lung
Over the last decade, the field of lung biology has evolved considerably due to many advancements, including the advent of single-cell RNA (scRNA)...
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Mechanics of Lung Development
We summarize how skeletal muscle and lung developmental biology fields have been bridged to benefit from mouse genetic engineering technologies and...
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Multipotent Embryonic Lung Progenitors: Foundational Units of In Vitro and In Vivo Lung Organogenesis
Transient, tissue-specific, embryonic progenitors are important cell populations in vertebrate development. In the course of respiratory system...
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Simple Models of Lung Development
Models are essential to further our understanding of lung development and regeneration and to facilitate identification and testing of potential...
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Lung Organoids: Systematic Review of Recent Advancements and its Future Perspectives
Organoids are essentially an in vitro (lab-grown) three-dimensional tissue culture system model that meticulously replicates the structure and...
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Influence of intersignaling crosstalk on the intracellular localization of YAP/TAZ in lung cells
A cell is a dynamic system in which various processes occur simultaneously. In particular, intra- and intercellular signaling pathway crosstalk has a...
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Lung development and regeneration: newly defined cell types and progenitor status
The lung is the most critical organ of the respiratory system supporting gas exchange. Constant interaction with the external environment makes the...
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Mice lacking DYRK2 exhibit congenital malformations with lung hypoplasia and altered Foxf1 expression gradient
Congenital malformations cause life-threatening diseases in pediatrics, yet the molecular mechanism of organogenesis is poorly understood. Here we...
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Lung Organoids: A New Pathway into Lung Regeneration and Repair
Introduction: The lung is an important and complicated organ that has profound impacts on the entire body when impacted by disease or illness. Due to...
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Advances in lymphatic metastasis of non-small cell lung cancer
Lung cancer is a deeply malignant tumor with high incidence and mortality. Despite the rapid development of diagnosis and treatment technology,...
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Reconstructing the pulmonary niche with stem cells: a lung story
The global burden of pulmonary disease highlights an overwhelming need in improving our understanding of lung development, disease, and treatment. It...
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A topographic atlas defines developmental origins of cell heterogeneity in the human embryonic lung
The lung contains numerous specialized cell types with distinct roles in tissue function and integrity. To clarify the origins and mechanisms...
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Lung Development in a Dish: Models to Interrogate the Cellular Niche and the Role of Mechanical Forces in Development
Over the past decade, emphasis has been placed on recapitulating in vitro the architecture and multicellular interactions found in organs in vivo [1,...
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Single cell RNA analysis uncovers the cell differentiation and functionalization for air breathing of frog lung
The evolution and development of vertebrate lungs have been widely studied due to their significance in terrestrial adaptation. Amphibians possess...
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Lung Organoid: Innovative Technology for Respiratory Disease Modelling
Introduction: The lungs are a complex organ with various cell types. Many factors can contribute to the damage of the lung epithelial cells,...