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Phytochemical Constituents of Rosmarinus officinalis Linn. and Their Associated Role in the Management of Alzheimer’s Disease
Neurodegenerative disorders, such as Alzheimer’s disease, lead to a gradual and irreversible loss of neurons and brain function, resulting in...
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Phytochemical Constituents of Rosmarinus officinalis Linn. and Their Associated Role in the Management of Alzheimer’s Disease
Neurodegenerative disorders, such as Alzheimer’s disease, lead to a gradual and irreversible loss of neurons and brain function, resulting in...
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Systems Biology Approaches as a Tool in Understanding Neurodevelopmental Disorders: Some Case Studies
Systems biology has emerged as a powerful approach in neurology and neurosciences, offering novel insights into the complex mechanisms underlying...
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RNA-binding proteins potentially regulate the alternative splicing of apoptotic genes during knee osteoarthritis progression
BackgroundAlternative splicing (AS) is a principal mode of genetic regulation and one of the most widely used mechanisms to generate structurally and...
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An impaired splicing program underlies differentiation defects in hSOD1G93A neural progenitor cells
Amyotrophic lateral sclerosis (ALS) is an adult devastating neurodegenerative disease characterized by the loss of upper and lower motor neurons...
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Oxy- and Phytosterols as Biomarkers: Current Status and Future Perspectives
Oxysterols and phytosterols are sterol compounds present at markedly low levels in tissues and serum of healthy individuals. A wealth of evidence...
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Emerging Role of Extracellular Vesicles in Intercellular Communication in the Brain: Implications for Neurodegenerative Diseases and Therapeutics
Extracellular vesicles (EVs) are minute lipid-bilayer sacs discharged by cells, encompassing a diverse array of proteins, nucleic acids, and lipids....
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Protein–Protein Interactions in Neurodegenerative Diseases
Neurodegeneration is a state of progressive decay of neuronal structure and function. It has gained scientific attention owing to the fact that...
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Animal Models of FUS-Proteinopathy: A Systematic Review
AbstractMutations that disrupt the function of the DNA/RNA-binding protein FUS could cause amyotrophic lateral sclerosis (ALS) and other...
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Characterization of Changes due to pH Variations in Beta Peptide (25–35) Leading to Alzheimer’s Disease
The effect of various concentrations of amyloid beta peptide (ABP) in different pH (pH 2, 6, 7, 8, 10) in aging at different time intervals was...
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Ebselen as template for stabilization of A4V mutant dimer for motor neuron disease therapy
Mutations to the gene encoding superoxide dismutase-1 (SOD1) were the first genetic elements discovered that cause motor neuron disease (MND). These...
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Adenosine to inosine RNA editing in animal cells
Major advances in the understanding of adenosine deaminases acting on RNA (ADARs) have come from the generation of ADAR mutant animals. In mice,...
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Fly for ALS: Drosophila modeling on the route to amyotrophic lateral sclerosis modifiers
Amyotrophic lateral sclerosis (ALS) is a rare, devastating disease, causing movement impairment, respiratory failure and ultimate death. A plethora...
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Nucleotide Exchange Factors for Hsp70 Molecular Chaperones: GrpE, Hsp110/Grp170, HspBP1/Sil1, and BAG Domain Proteins
Molecular chaperones of the Hsp70 family are key components of the cellular protein-folding machinery. Substrate folding is accomplished by iterative...
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Protein Misfolding and Neurodegenerative Diseases
A protein must fold into a three-dimensional structure and maintain its tertiary/quaternary structure for proper function. To control all the vital...
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Endophytic fungi: a potential source for drugs against central nervous system disorders
Neuroprotection is one of the important protection methods against neuronal cells and tissue damage caused by neurodegenerative diseases such as...
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Zinc antagonizes iron-regulation of tyrosine hydroxylase activity and dopamine production in Drosophila melanogaster
BackgroundDopamine (DA) is a neurotransmitter that plays roles in movement, cognition, attention, and reward responses, and deficient DA signaling is...
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Towards a Continuous Production of Human Mesenchymal Stromal Cells in a Chemically Defined Medium: Opportunities and Challenges for a Robust and Scalable Expansion Process
Human mesenchymal stromal cells (hMSCs) are one of the most prominent cell types used for cell therapy application. Thereby the current clinical...
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Defects in Protein Folding and/or Quality Control Cause Protein Aggregation in the Endoplasmic Reticulum
Protein aggregation is now a common hallmark of numerous human diseases, most of which involve cytosolic aggregates including Aβ (AD) and ⍺-synuclein...