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Genetic deletion of phosphodiesterase 4D in the liver improves kidney damage in high-fat fed mice: liver-kidney crosstalk
A growing body of epidemiological evidence suggests that nonalcoholic fatty liver disease (NAFLD) is an independent risk factor for chronic kidney...
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Restoring skeletal muscle mass as an independent determinant of liver fat deposition improvement in MAFLD
AimsCross-sectional studies have demonstrated the association of skeletal muscle mass with metabolic-associated fatty liver disease (MAFLD), while...
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Investigation of Advanced Glycation End Products in Liver, Adipose, and Renal Tissue of Mice on a High-Fat Diet
Obesity is a complex condition associated with disruptions in carbohydrate, protein, and fat metabolism, linked to increased insulin resistance and...
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Exploring the dynamic three-dimensional chromatin architecture and transcriptional landscape in goose liver tissues underlying metabolic adaptations induced by a high-fat diet
BackgroundGoose, descendants of migratory ancestors, have undergone extensive selective breeding, resulting in their remarkable ability to accumulate...
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Effect of replacement of soybean oil by Hermetia illucens fat on performance, digestibility, cecal microbiome, liver transcriptome and liver and plasma lipidomes of broilers
BackgroundIn contrast to protein-rich insect meal, the feed potential of insect fat is generally less explored and knowledge about the suitability of...
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High fat diet reveals sex-specific fecal and liver metabolic alterations in C57BL/6J obese mice
Obesity is a major health concern that poses significant risks for many other diseases, including diabetes, cardiovascular disease, and cancer....
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Substitution of cooked kidney beans or ground beef in hypercholesterolemic high fat diets reduces plasma and liver lipids in hamsters
This study examined the physiological effects of replacing some of the casein with either a plant based, animal or combination of protein sources in...
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Association of body fat and muscle tissue parameters with fatty liver disease identified by ultrasound
AimsTo examine the association between body fat and muscle parameters and FLD in individuals of Chinese descent.
MethodsA total of 515 participants...
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Chicken cecal microbiota reduces abdominal fat deposition by regulating fat metabolism
Cecal microbiota plays an essential role in chicken health. However, its contribution to fat metabolism, particularly in abdominal fat deposition,...
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The link between liver fat and cardiometabolic diseases is highlighted by genome-wide association study of MRI-derived measures of body composition
Obesity and associated morbidities, metabolic associated fatty liver disease (MAFLD) included, constitute some of the largest public health threats...
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Chitosan-based delivery of fish codon-optimised Caenorhabditis elegans FAT-1 and FAT-2 boosts EPA and DHA biosynthesis in Sparus aurata
Omega-3 long-chain polyunsaturated fatty acids ( n -3 LC-PUFA) are essential fatty acids required in healthy balanced diets for humans. To induce...
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Increased visceral fat area to skeletal muscle mass ratio is positively associated with the risk of metabolic dysfunction-associated steatotic liver disease in a Chinese population
BackgroundThe diagnosis and comprehension of nonalcoholic fatty liver disease (NAFLD), recently redefined as metabolic dysfunction-associated...
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Relationship of liver fat content with systemic metabolism and chronic complications in patients with type 2 diabetes mellitus
ObjectiveThis study investigated the correlation of liver fat content (LFC) with metabolic characteristics and its association with chronic...
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Human milk-derived extracellular vesicles alleviate high fat diet-induced non-alcoholic fatty liver disease in mice
BackgroundNonalcoholic fatty liver disease (NAFLD), characterized by excessive hepatic lipid accumulation, imposes serious challenges on public...
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Fat mass and obesity–associated protein promotes liver steatosis by targeting PPARα
BackgroundNonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. The fat mass and obesity–associated protein...
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High-fat diet intake ameliorates the expression of hedgehog signaling pathway in adult rat liver
BackgroundDisproportionate fatty diet intake provokes hepatic lipid accumulation that causes non-alcoholic fatty liver disease, triggering the...
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SHMT2 reduces fatty liver but is necessary for liver inflammation and fibrosis in mice
Non-alcoholic fatty liver disease is associated with an irregular serine metabolism. Serine hydroxymethyltransferase 2 (SHMT2) is a liver enzyme that...
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Dietary fat supplementation relieves cold temperature-induced energy stress through AMPK-mediated mitochondrial homeostasis in pigs
BackgroundCold stress has negative effects on the growth and health of mammals, and has become a factor restricting livestock development at high...
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The gut–liver axis and gut microbiota in health and liver disease
The trillions of microorganisms in the human intestine are important regulators of health, and disruptions in the gut microbial communities can cause...
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Therapeutic potential of Lactobacillus casei and Chlorella vulgaris in high-fat diet-induced non-alcoholic fatty liver disease (NAFLD)-associated kidney damages: a stereological study
BackgroundThe non-alcoholic fatty liver disease (NAFLD) is prevalent in as many as 25% of adults who are afflicted with metabolic syndrome. Oxidative...
