Search
Search Results
-
In vitro phenotypic effects of Lipoxin A4 on M1 and M2 polarized macrophages derived from THP-1
BackgroundLipoxin A4 (LXA4) is a specialized pro-resolving mediator involved in the resolution phase of inflammation that is crucial for the return...
-
Lipoxin A4 promotes adipogenic differentiation and browning of mouse embryonic fibroblasts
Recently, it has been irrefutably discovered that brown adipocytes dissipate energy as heat and protect against obesity. Researchers make great...
-
PUFAs, BDNF and lipoxin A4 inhibit chemical-induced cytotoxicity of RIN5F cells in vitro and streptozotocin-induced type 2 diabetes mellitus in vivo
ObjectiveTo study whether minimal doses of arachidonic acid (AA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and lipoxin A4 (LXA4)...
-
Liposome-Encapsulated Anti-inflammatory Proteins for Targeted Delivery to the Placenta to Treat Fetal Growth Restriction
Fetal growth restriction (FGR), the failure of a fetus to reach its genetically determined growth potential, is a serious complication affecting up...
-
Lipoxin A4 suppresses angiotensin II type 1 receptor autoantibody in preeclampsia via modulating caspase-1
Preeclampsia (PE) remains a leading cause of maternal and neonatal morbidity and mortality. Numerous studies have shown that women with PE develop...
-
Syntaxin interacts with arachidonic acid to prevent diabetes mellitus
Syntaxin regulates pancreatic β cell mass and participates in insulin secretion by regulating insulin exocytosis. In addition, syntaxin 4 reduces...
-
Cystathionine gamma-lyase (Cth) induces efferocytosis in macrophages via ERK1/2 to modulate intestinal barrier repair
BackgroundThe inflammatory response induced by intestinal ischaemia‒reperfusion injury (I/R) is closely associated with infectious complications and...
-
Docosahexaenoic acid-rich algae oil supplementation in mothers of preterm infants is associated with a modification in breast milk oxylipins profile
Oxylipins are derived from enzymatic and non-enzymatic oxidation of n -3 and n -6 long-chain polyunsaturated fatty acids. They are known to be involved...
-
LXA4-FPR2 signaling regulates radiation-induced pulmonary fibrosis via crosstalk with TGF-β/Smad signaling
Radiation therapy is an important modality in the treatment of lung cancer, but it can lead to radiation pneumonitis, and eventually radiation...
-
Modulating AHR function offers exciting therapeutic potential in gut immunity and inflammation
Aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a classical exogenous...
-
Can essential fatty acids (EFAs) prevent and ameliorate post-COVID-19 long haul manifestations?
It is hypothesized that COVID-19, post-COVID and post-mRNA COVID-19 (and other related) vaccine manifestations including “long haul syndrome” are due...
-
Role for animal models in understanding essential fatty acid deficiency in cystic fibrosis
Essential fatty acid deficiency has been observed in most patients with Cystic Fibrosis (CF); however, pancreatic supplementation does not restore...
-
Clearance of apoptotic cells by neutrophils in inflammation and cancer
When a cell dies of apoptosis, it is eliminated either by neighbouring cells or by attracted professional phagocytes. Although it was generally...
-
A review of non-prostanoid, eicosanoid receptors: expression, characterization, regulation, and mechanism of action
Eicosanoid signaling controls a wide range of biological processes from blood pressure homeostasis to inflammation and resolution thereof to the...
-
Interplay between PI3K/AKT pathway and heart disorders
The PI3K/AKT signaling has crucial role in the regulation of numerous physiological functions through activation of downstream effectors and...
-
Bioactive Lipids in Age-Related Disorders
Our own studies and those of others have shown that defects in essential fatty acid (EFA) metabolism occurs in age-related disorders such as obesity,...
-
Triggers for the onset and recurrence of psoriasis: a review and update
Psoriasis is an immune-mediated inflammatory skin disease, involving a complex interplay between genetic and environmental factors. Previous studies...
-
Revolutionizing control strategies against Mycobacterium tuberculosis infection through selected targeting of lipid metabolism
Lipid species play a critical role in the growth and virulence expression of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis...
-
Types of necroinflammation, the effect of cell death modalities on sterile inflammation
Distinct types of immune responses are activated by infections, which cause the development of type I, II, or III inflammation, regulated by Th1,...
