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Fat storage-inducing transmembrane proteins: beyond mediating lipid droplet formation
Fat storage-inducing transmembrane proteins (FITMs) were initially identified in 2007 as members of a conserved endoplasmic reticulum (ER) resident...
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Lipid metabolism and storage in neuroglia: role in brain development and neurodegenerative diseases
The importance of neuroglia in maintaining normal brain function under physiological and pathological conditions has been supported by growing...
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Lipid Metabolism
Lipids are a heterogeneous group of water-insoluble compounds that are soluble in organic solvents. Besides being an important constituent of the...
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Lipid droplets and cellular lipid flux
Lipid droplets are dynamic organelles that store neutral lipids, serve the metabolic needs of cells, and sequester lipids to prevent lipotoxicity and...
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Lipid Metabolism and Homeostasis in Ferroptosis
Lipids are a diverse group of molecules that are crucial for cell structure, energy storage, and cell signaling. Maintaining lipid homeostasis...
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Are lipid droplets the picnic basket of brain tumours?
Are lipid droplets (LDs) necessary to maintain the viability of brain tumour cells as they move to new nutrient-poor environments? In turn, could...
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Overcoming thermostability challenges in mRNA–lipid nanoparticle systems with piperidine-based ionizable lipids
Lipid nanoparticles (LNPs) have emerged as promising platforms for efficient in vivo mRNA delivery owing to advancements in ionizable lipids....
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Lipid overload-induced RTN3 activation leads to cardiac dysfunction by promoting lipid droplet biogenesis
Lipid droplet (LD) accumulation is a notable feature of obesity-induced cardiomyopathy, while underlying mechanism remains poorly understood. Here we...
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Community composition and physiological plasticity control microbial carbon storage across natural and experimental soil fertility gradients
Many microorganisms synthesise carbon (C)-rich compounds under resource deprivation. Such compounds likely serve as intracellular C-storage pools...
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Extended supercooled storage of red blood cells
Red blood cell (RBC) transfusions facilitate many life-saving acute and chronic interventions. Transfusions are enabled through the gold-standard...
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Reprogramming of lipid metabolism in the tumor microenvironment: a strategy for tumor immunotherapy
Lipid metabolism in cancer cells has garnered increasing attention in recent decades. Cancer cells thrive in hypoxic conditions, nutrient deficiency,...
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Microglia Lipid Droplets in Physiology and Neurodegeneration
Lipid droplets (LDs) are dynamic organelles found in organisms ranging from yeast to humans. Originally thought of as inert lipid-storing structures,...
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Solid Lipid Nanoparticles for Drug Delivery
Solid lipid nanoparticlesSolid lipid nanoparticles (SLNs) are promising carriers that allow for the delivery of poorly water-soluble drugs and have...
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PGC-1α repression dysregulates lipid metabolism and induces lipid droplet accumulation in the retinal pigment epithelium
Drusen, the yellow deposits under the retina, are composed of lipids and proteins, and represent a hallmark of age-related macular degeneration...
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Manipulation of photoperiod induces fat storage, but not fat mobilization in the migratory songbird, Dumetella carolinensis (Gray Catbird)
The annual cycle of migratory birds requires significant phenotypic remodeling. We sought to induce the migratory phenotype in Gray Catbirds by...
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LiLA: lipid lung-based ATLAS built through a comprehensive workflow designed for an accurate lipid annotation
Accurate lipid annotation is crucial for understanding the role of lipids in health and disease and identifying therapeutic targets. However,...
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Electron Beam Irradiation Inhibited Potato Sprouting by Regulating the Metabolism of Membrane Lipid Peroxidation and Antioxidant
This study evaluated the effects of high-energy electron beams (e-beams) on sprouting, physical–chemical properties and membrane lipid peroxidation...
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Visualizing Lipid Droplets in Drosophila Oogenesis
Lipid droplets (LDs) are fat storage organelles highly abundant in oocytes and eggs of many vertebrates and invertebrates. They have roles both...
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SB2301-mediated perturbation of membrane composition in lipid droplets induces lipophagy and lipid droplets ubiquitination
Lipid droplets (LDs) are involved in various biological events in cells along with their primary role as a storage center for neutral lipids....
