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PGC-1α repression dysregulates lipid metabolism and induces lipid droplet accumulation in the retinal pigment epithelium
Drusen, the yellow deposits under the retina, are composed of lipids and proteins, and represent a hallmark of age-related macular degeneration...
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Anlotinib affects systemic lipid metabolism and induces lipid accumulation in human lung cancer cells
BackgroundAnlotinib has demonstrated encouraging clinical outcomes in the treatment of lung cancer, soft tissue sarcoma and thyroid carcinoma....
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Nesfatin-1 and nesfatin-1-like peptide attenuate hepatocyte lipid accumulation and nucleobindin-1 disruption modulates lipid metabolic pathways
Nesfatin-1 (NESF-1) has been shown to modulate lipid metabolism. We have identified a nesfatin-1-like-peptide (NLP) processed from a related...
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Influence of Culture Conditions on the Microalgal Biomass and Lipid Accumulation
In the current situation, almost every industrial and transportation activities are dependent on fossil fuels for their energy requirements. Fossil...
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Disturbed intracellular folate homeostasis impairs autophagic flux and increases hepatocytic lipid accumulation
BackgroundMetabolic associated fatty liver disease (MAFLD), a prevalent liver disorder affecting one-third of the global population, encompasses a...
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ACSM5 inhibits ligamentum flavum hypertrophy by regulating lipid accumulation mediated by FABP4/PPAR signaling pathway
BackgroundLigamentum flavum (LF) hypertrophy is the main cause of lumbar spinal canal stenosis (LSCS). Previous studies have shown that LF...
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Palmitic acid induces lipid droplet accumulation and senescence in nucleus pulposus cells via ER-stress pathway
Intervertebral disc degeneration (IDD) is a highly prevalent musculoskeletal disorder affecting millions of adults worldwide, but a poor...
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A homoeostatic switch causing glycerol-3-phosphate and phosphoethanolamine accumulation triggers senescence by rewiring lipid metabolism
Cellular senescence affects many physiological and pathological processes and is characterized by durable cell cycle arrest, an inflammatory...
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Association between indicators of visceral lipid accumulation and infertility: a cross-sectional study based on U.S. women
BackgroundEvidence on the association between visceral lipid accumulation and infertility remains limited and controversial. Therefore, the current...
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Lipid droplet accumulation in Wdr45-deficient cells caused by impairment of chaperone-mediated autophagic degradation of Fasn
Backgroundβ-Propeller protein-associated neurodegeneration (BPAN) is a genetic neurodegenerative disease caused by mutations in WDR45 . The...
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Loss of Dec1 inhibits alcohol-induced hepatic lipid accumulation and circadian rhythm disorder
Chronic alcohol exposure increases liver damage such as lipid accumulation and hepatitis, resulting in hepatic cirrhosis. Chronic alcohol intake is...
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Deubiquitinase USP1 enhances CCAAT/enhancer-binding protein beta (C/EBPβ) stability and accelerates adipogenesis and lipid accumulation
Dysregulation of the ubiquitin-proteasome system has been implicated in the pathogenesis of several metabolic disorders, including obesity, diabetes,...
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PLIN2-induced ectopic lipid accumulation promotes muscle ageing in gregarious locusts
Ageing plasticity represents the flexibility of the ageing process in response to non-genetic factors, occurring commonly in animals. However, the...
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Effect of carbon and nitrogen concentrations on lipid accumulation and regulation of acetyl-CoA carboxylase in Papiliotrema laurentii
Biodiesel is an interesting alternative to petroleum diesel as it is renewable, biodegradable, and has a low pollutant content. Yeast oils can be...
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Association between lipid accumulation product and psoriasis among adults: a nationally representative cross-sectional study
BackgroundLipid accumulation product (LAP) is an accessible and relatively comprehensive assessment of obesity that represents both anatomical and...
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Lipid accumulation and SNF1 transcriptional analysis of Mucor circinelloides on xylose under nitrogen limitation
Sucrose non-fermenting 1 (SNF1) plays a crucial role in utilizing non-glucose carbon sources and regulating lipid metabolism. However, the mechanism...
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Lactiplantibacillus sp. D10-2: potential bacteria for eliminating bisphenol A and reducing BpA-induced lipid accumulation
Bisphenol A (BpA) is an endocrine-disrupting substance commonly found in plastics and resins. It is reported that BpA exposure induces lipid...
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TOLLIP inhibits lipid accumulation and the integrated stress response in alveolar macrophages to control Mycobacterium tuberculosis infection
A polymorphism causing deficiencies in Toll-interacting protein (TOLLIP), an inhibitory adaptor protein affecting endosomal trafficking, is...
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Exogenous ethanol induces cell giantism accompanied by enhanced accumulation of lipid and carbohydrates in Chlorella sorokiniana
Ethanol has been reported as a supplementary substrate for microalgae cultivation, however, information about its effect on the morphology, growth...
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Magnesium Supplementation Stimulates Autophagy to Reduce Lipid Accumulation in Hepatocytes via the AMPK/mTOR Pathway
Metabolic-associated fatty liver disease (MAFLD) (previously known as nonalcoholic fatty liver disease (NAFLD)) is a disease with high worldwide...
