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Combining albumin deficiency and acute exercise reduces hepatic lipid droplet size in mice
Hepatic lipid droplets (LDs) are implicated in ectopic lipid accumulation. The core of LDs, triacylglycerol (TAG), is synthesized from the...
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PGC-1α repression dysregulates lipid metabolism and induces lipid droplet accumulation in the retinal pigment epithelium
Drusen, the yellow deposits under the retina, are composed of lipids and proteins, and represent a hallmark of age-related macular degeneration...
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Glycolytic enzyme PFKL governs lipolysis by promoting lipid droplet–mitochondria tethering to enhance β-oxidation and tumor cell proliferation
Lipid droplet tethering with mitochondria for fatty acid oxidation is critical for tumor cells to counteract energy stress. However, the underlying...
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Droplet size and hydraulic spray nozzles in peanut plant spray deposition
The quantity and quality of spray deposition are fundamental for improving pesticide performance in plant pests. This study evaluated how spray...
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Lipid droplet-associated lncRNA LIPTER preserves cardiac lipid metabolism
Lipid droplets (LDs) are cellular organelles critical for lipid homeostasis, with intramyocyte LD accumulation implicated in metabolic...
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Fat storage-inducing transmembrane proteins: beyond mediating lipid droplet formation
Fat storage-inducing transmembrane proteins (FITMs) were initially identified in 2007 as members of a conserved endoplasmic reticulum (ER) resident...
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Qa-SNARE syntaxin 18 mediates lipid droplet fusion with SNAP23 and SEC22B
Lipid droplets (LDs) are dynamic lipid storage organelles that can sense and respond to changes in systemic energy balance. The size and number of...
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Fusion of Peroxisome and Lipid Droplet Membranes: Expansion of a π-Shaped Structure
AbstractClassical theory of fusion considers the fusion of bilayer membranes as a unification of the material of the membranes themselves and the...
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Energy Barrier of a Monolayer Stalk Formation during Lipid Droplet Fusion
AbstractLipid droplets are organelles responsible for the accumulation and breakdown of neutral fats in the human body. Lipid droplets have a...
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Dehydroascorbic acid sensitizes cancer cells to system xc- inhibition-induced ferroptosis by promoting lipid droplet peroxidation
Since the discovery of ferroptosis, it has been postulated that this type of cell death could be utilized in treatments for cancer. Unfortunately,...
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Exploring selection signatures in the divergence and evolution of lipid droplet (LD) associated genes in major oilseed crops
BackgroundOil bodies or lipid droplets (LDs) in the cytosol are the subcellular storage compartments of seeds and the sites of lipid metabolism...
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A lipid droplet-associated protein Nem1 regulates appressorium function for infection of Magnaporthe oryzae
Lipid droplets are important storages in fungal conidia and can be used by plant pathogenic fungi for infection. However, the regulatory mechanism of...
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Lipid droplets and cellular lipid flux
Lipid droplets are dynamic organelles that store neutral lipids, serve the metabolic needs of cells, and sequester lipids to prevent lipotoxicity and...
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Downregulation of Elovl5 promotes breast cancer metastasis through a lipid-droplet accumulation-mediated induction of TGF-β receptors
Metastatic breast cancer cannot be cured, and alteration of fatty acid metabolism contributes to tumor progression and metastasis. Here, we were...
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Cancer radioresistance is characterized by a differential lipid droplet content along the cell cycle
BackgroundCancer radiation treatments have seen substantial advancements, yet the biomolecular mechanisms underlying cancer cell radioresistance...
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TRIB3 promotes the progression of renal cell carcinoma by upregulating the lipid droplet-associated protein PLIN2
Abnormal lipid metabolism and lipid accumulation are characteristic hallmarks of renal cell carcinoma (RCC). While there is prior evidence closely...
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Characterization of a lipid droplet and endoplasmic reticulum stress related gene risk signature to evaluate the clinical and biological value in hepatocellular carcinoma
IntroductionLipid metabolism and endoplasmic reticulum (ER) stress play an important role in the progression and metastasis of hepatocellular...
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Knockdown of NEAT1 prevents post-stroke lipid droplet agglomeration in microglia by regulating autophagy
BackgroundLipid droplets (LD), lipid-storing organelles containing neutral lipids like glycerolipids and cholesterol, are increasingly accepted as...
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Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation
Metabolic switch is critical for cell fate determination through metabolic functions, epigenetic modifications, and gene expression. However, the...
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The GTP-Bound form of Rab3D Promotes Lipid Droplet Growth in Adipocyte
AbstractRab GTPases are major regulators of membrane trafficking. Proteome profiling reveals dozens of Rab proteins associated with lipid droplets...
