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Human Blood Serum Counteracts EGFR/HER2-Targeted Drug Lapatinib Impact on Squamous Carcinoma SK-BR-3 Cell Growth and Gene Expression
AbstractLapatinib is a targeted therapeutic inhibiting HER2 and EGFR proteins. It is used for the therapy of HER2-positive breast cancer, although...
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Co-loaded lapatinib/PAB by ferritin nanoparticles eliminated ECM-detached cluster cells via modulating EGFR in triple-negative breast cancer
Cancer stem cell (CSC) cluster of triple-negative breast cancer (TNBC) is suggested to be responsible for therapy resistance, metastatic process and...
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Loss of Kmt2c in vivo leads to EMT, mitochondrial dysfunction and improved response to lapatinib in breast cancer
Deep sequencing of human tumours has uncovered a previously unappreciated role for epigenetic regulators in tumorigenesis. H3K4 methyltransferase KMT2C/MLL3...
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Chromosomal instability reducing effect of paclitaxel and lapatinib in mouse embryonic stem cells with chromosomal abnormality
Chromosomal abnormalities, as a frequent phenomenon in cultured embryonic stem cells (ESCs), is a major obstacle in the ESC application in...
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Targeting AFP-RARβ complex formation: a potential strategy for treating AFP-positive hepatocellular carcinoma
Alpha-fetoprotein (AFP) is a glycoprotein primarily expressed during embryogenesis, with declining levels postnatally. Elevated AFP levels correlate...
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Potential protein kinase inhibitors that target G-quadruplex DNA structures in the human telomeric regions
Telomeric regions contain Guanine-rich sequences arranged in a planar manner and connected by Hoogsteen hydrogen bonds that can fold into...
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Metformin alleviates ethanol-induced cardiomyocyte injury by activating AKT/Nrf2 signaling in an ErbB2-dependent manner
BackgroundMetformin, a first-line oral anti-diabetic drug, has recently been reported to exert protective effect on various cardiovascular diseases....
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Synthesis, and biological evaluation of EGFR/HER2-NAMPT conjugates for tumor treatment
Throughout the reported applications of EGFR inhibitors, it is usually employed with HDAC or other targets to design multi-target inhibitors for...
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Construction and Analysis of a Mitochondrial Metabolism-Related Prognostic Model for Breast Cancer to Evaluate Survival and Immunotherapy
As one of the most prevalent malignancies among women, breast cancer (BC) is tightly linked to metabolic dysfunction. However, the correlation...
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An efficient methodological approach for synthesis of selenopyridines: generation, reactions, anticancer activity, EGFR inhibitory activity and molecular docking studies
In the present work, we successfully synthesized Se -alkyl selenopyridines 1 and 3 , selenopheno[2,3- b ]pyridine 2 , and bis-selenopyridine 4 derivatives...
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Exosomal annexin A6 induces gemcitabine resistance by inhibiting ubiquitination and degradation of EGFR in triple-negative breast cancer
Exosomes are carriers of intercellular information that regulate the tumor microenvironment, and they have an essential role in drug resistance...
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Targeting transcription of MCL-1 sensitizes HER2-amplified breast cancers to HER2 inhibitors
Human epidermal growth factor receptor 2 gene ( HER2 ) is focally amplified in approximately 20% of breast cancers. HER2 inhibitors alone are not...
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Oncoinformatic screening of the gene clusters involved in the HER2-positive breast cancer formation along with the in silico pharmacodynamic profiling of selective long-chain omega-3 fatty acids as the metastatic antagonists
AbstractThe HER2-positive patients occupy ~ 30% of the total breast cancer patients globally where no prevalent drugs are available to mitigate the...
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MAVEN: compound mechanism of action analysis and visualisation using transcriptomics and compound structure data in R/Shiny
BackgroundUnderstanding the Mechanism of Action (MoA) of a compound is an often challenging but equally crucial aspect of drug discovery that can...
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Comprehensive analysis of cuproptosis-related lncRNAs in immune infiltration and prognosis in hepatocellular carcinoma
BackgroundBeing among the most common malignancies worldwide, hepatocellular carcinoma (HCC) accounting for the third cause of cancer mortality. The...
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VIBRANT: spectral profiling for single-cell drug responses
High-content cell profiling has proven invaluable for single-cell phenoty** in response to chemical perturbations. However, methods with improved...
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The Role of ERBB2/HER2 Tyrosine Kinase Receptor in the Regulation of Cell Death
AbstractHER2 (Human Epidermal Growth Factor Receptor 2), also known as ERBB2, CD340, and Neu protooncogene, is a member of the epidermal growth...
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Heat shock factor 1 confers resistance to lapatinib in ERBB2-positive breast cancer cells
Despite success of ERBB2-targeted therapies such as lapatinib, resistance remains a major clinical concern. Multiple compensatory receptor tyrosine...
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Translating transcriptomic findings from cancer model systems to humans through joint dimension reduction
Model systems are an essential resource in cancer research. They simulate effects that we can infer into humans, but come at a risk of inaccurately...
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Rattus norvegicus Spermatogenesis Colony-Forming Assays
Knowledge gaps persist on signaling pathways and metabolic states in germ cells sufficient to support spermatogenesis independent of a somatic...