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Induced expression of Ganoderma boninense Lanosterol 14α-Demethylase (ERG11) during interaction with oil palm
BackgroundThe basidiomycete fungus, Ganoderma boninense is the main contributor to oil palm Basal Stem Rot (BSR) in Malaysia and Indonesia....
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Synthesis, Characterization, Antimicrobial, and Molecular Docking Studies of Thiazolidin-4-one Derivatives fused with Indole and Pyrimidine Moieties
AbstractA series of fifteen 2-substituted-3-(4-(pyridin-2-yl)-6-(1 H -pyrrolo[2,3- b ]pyridin-4-yl)pyrimidin-2-yl)thiazolidin-4-one, was prepared and...
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In Vitro and In Silico Analysis of Ascorbic Acid Towards Lanosterol 14-α-Demethylase Enzyme of Fluconazole-Resistant Candida albicans
Antibiotic resistance is one of the major concerns and the biggest threats to the world population. The incidents of antibiotic resistance in Candida ...
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The bHLH-zip transcription factor SREBP regulates triterpenoid and lipid metabolisms in the medicinal fungus Ganoderma lingzhi
Ganoderic acids (GAs) are well recognized as important pharmacological components of the medicinal species belonging to the basidiomycete genus Ganoderma...
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An omics-based characterization of Wolfiporia cocos reveals three CYP450 members involved in the biosynthetic pathway of pachymic acid
Wolfiporia cocos is a medicinal mushroom used in China. It biosynthesizes pachymic acid (PA), a main therapeutic triterpene associated with...
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New thymol-derived triazole exhibits promising activity against Trichophyton rubrum
Fungal infections have emerged worldwide, and azole antifungals are widely used to control these infections. However, the emergence of antifungal...
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Azole resistance in Aspergillus fumigatus- comprehensive review
Aspergillus fumigatus is a ubiquitous filamentous fungus commonly found in the environment. It is also an opportunistic human pathogen known to cause...
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Functional characterization of genes related to triterpene and flavonoid biosynthesis in Cyclocarya paliurus
Main conclusionThe oxidosqualene cyclases (OSCs) generating triterpenoid skeletons in Cyclocarya paliurus were identified for the first time, and...
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Antibacterial Activity, Phytochemical Analysis of C. coggygria Leaf Extracts Against S. typhi, and Computational Studies to Screen Potential Drug Candidates
Typhoid fever is a serious infectious disease caused by Salmonella typhi and Salmonella Paratyphi A. Although there are several drugs available for...
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Characterization of oxidosqualene cyclases from Trichosanthes cucumerina L. reveals key amino acids responsible for substrate specificity of isomultiflorenol synthase
Main conclusionTwo key amino acids of isomultiflorenol synthase, Y125 and M254, were first proposed. They could be associated with the production of...
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Sulfur, sterol and trehalose metabolism in the deep-sea hydrocarbon seep tubeworm Lamellibrachia luymesi
BackgroundLamellibrachia luymesi dominates cold sulfide-hydrocarbon seeps and is known for its ability to consume bacteria for energy. The symbiotic...
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Analysis of the Products of Extraction and Water-Alkaline Hydrolysis of Technical Birch Bark under Microwave EMF Exposure
AbstractResearch was carried out on the isolation of betulin and suberin from the debarking waste of the Arkhangelsk Pulp and Paper Mill pulpwood,...
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Nonhost resistance EST profiling of wheat interacting with Blumeria graminis f. sp. hordei identifies genes for durable resistance to powdery mildew
Microbial pathogens cause great losses in many crops, including wheat. Plants overcome pathogen attack by triggering defense mechanisms relying on...
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In vitro study on the potential fungicidal effects of atorvastatin in combination with some azole drugs against multidrug resistant Candida albicans
The resistance of Candida albicans to azole drugs represents a great global challenge. This study investigates the potential fungicidal effects of...
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The Diagnostic Use of the Plasma Quantification of 24S-Hydroxycholesterol and Other Oxysterols in Neurodegenerative Disease
Cholesterol regulates fluidity and structure of cellular membranes. The brain is involved in signal transduction, synaptogenesis, and membrane...
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4 Defects in cholesterol biosynthesis
Defects in eight different enzymes of cholesterol biosynthesis that result in serious clinical consequences have been identified. Most of these were...
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6 Sterol biochemistry and regulation in the yeast Saccharomyces cerevisiae
Saccharomyces cerevisiae has been a major model system for the study of sterol biosynthesis and function. All of the genes encoding the enzymes...
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The transcription factor Cas5 suppresses hyphal morphogenesis during yeast-form growth in Candida albicans
Candida albicans is an opportunistic human pathogen that exists as yeast, hyphal or pseudohyphal forms depending on pH, nutrients, and temperature....
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Advances in the biosynthesis, diversification, and hyperproduction of ganoderic acids in Ganoderma lucidum
Ganoderic acids (GA) are one of the important secondary metabolites acquired from Ganoderma lucidum ( G. lucidum ) with a wide range of pharmacological...
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Biosynthesis of a Novel Ganoderic Acid in Saccharomyces cerevisiae and Research of its Antitumor Activity
AbstractGanoderic acids (GAs), mainly from the traditional Chinese medicinal Ganoderma lucidum , possess antitumor, anti-metastasis and other...
