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Human lactate dehydrogenase and malate dehydrogenase possess the catalytic properties to produce aromatic α-hydroxy acid
Lactate dehydrogenase and malate dehydrogenase are the two main alpha-hydroxy acid dehydrogenases in the human body. We investigated the catalytic...
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Lactate dehydrogenase A promotes nasopharyngeal carcinoma progression through the TAK1/NF-κB Axis
BackgroundNasopharyngeal carcinoma (NPC) is a malignant tumor that originates in the nasopharyngeal mucosa and is common in China and Southeast Asian...
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Tripartite-motif 3 represses ovarian cancer progression by downregulating lactate dehydrogenase A and inhibiting AKT signaling
The E3 ubiquitin ligase Tripartite-motif 3 (TRIM3) is known to play a crucial role in tumor suppression in various tumors through different...
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Catalytic Properties of Lactate Dehydrogenase in Skeletal Muscles and Liver of the Marsh Frog (Pelophylax ridibundus) Depend on Its Ecologo-Geographical Habitats
AbstractThe marsh frog Pelophylax ridibundus has an extensive distribution range owing to a variety of adaptations that contribute to the...
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Characterisation of Plasmodium vivax lactate dehydrogenase dynamics in P. vivax infections
Plasmodium vivax lactate dehydrogenase (PvLDH) is an essential enzyme in the glycolytic pathway of P. vivax . It is widely used as a diagnostic...
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A functionally uncharacterized type-2 malate/l-lactate dehydrogenase family protein from Thermus thermophilus HB8 catalyzes stereospecific reduction of 2-keto-3-deoxy-d-gluconate
2-Keto-3-deoxy- d -gluconate (KDG) is an important intermediate found in various sugars, sugar acids and polysaccharide catabolic pathways. Here, we...
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PDK4-dependent hypercatabolism and lactate production of senescent cells promotes cancer malignancy
Senescent cells remain metabolically active, but their metabolic landscape and resulting implications remain underexplored. Here, we report...
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Targeting lactate dehydrogenase B-dependent mitochondrial metabolism affects tumor initiating cells and inhibits tumorigenesis of non-small cell lung cancer by inducing mtDNA damage
Once considered a waste product of anaerobic cellular metabolism, lactate has been identified as a critical regulator of tumorigenesis, maintenance,...
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Relationship between L-lactate dehydrogenase and multidrug resistance in Staphylococcus xylosus
Staphylococcus xylosus is a gram-positive bacterium that has attracted much attention due to its increasing clinical appearance, frequently...
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PDHA1 hyperacetylation-mediated lactate overproduction promotes sepsis-induced acute kidney injury via Fis1 lactylation
The increase of lactate is an independent risk factor for patients with sepsis-induced acute kidney injury (SAKI). However, whether elevated lactate...
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Emerging roles of lactate in acute and chronic inflammation
Traditionally, lactate has been considered a ‘waste product’ of cellular metabolism. Recent findings have shown that lactate is a substance that...
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The role of lactate in cardiovascular diseases
Cardiovascular diseases pose a major threat worldwide. Common cardiovascular diseases include acute myocardial infarction (AMI), heart failure,...
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Modified catalytic performance of Lactobacillus fermentum l-lactate dehydrogenase by rational design
l -Lactate dehydrogenases can reduce alpha-keto carboxylic acids asymmetrically and generally have a broad substrate spectrum. l -Lactate dehydrogenase...
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Lactate formation from fructose or C1 compounds in the acetogen Acetobacterium woodii by metabolic engineering
AbstractAnaerobic, acetogenic bacteria are promising biocatalysts for a sustainable bioeconomy since they capture and convert carbon dioxide to...
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Lactate: an alternative pathway for the immunosuppressive properties of mesenchymal stem/stromal cells
BackgroundThe metabolic reprogramming of mesenchymal stem/stromal cells (MSC) favoring glycolysis has recently emerged as a new approach to improve...
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Efficient production of acetoin from lactate by engineered Escherichia coli whole-cell biocatalyst
Acetoin, an important and high-value added bio-based platform chemical, has been widely applied in fields of foods, cosmetics, chemical synthesis,...
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Myeloid-derived suppressor cells impair CD4+ T cell responses during chronic Staphylococcus aureus infection via lactate metabolism
Staphylococcus aureus is an important cause of chronic infections resulting from the failure of the host to eliminate the pathogen. Effective S. aureus ...
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Perilipin 5 deficiency aggravates cardiac hypertrophy by stimulating lactate production in leptin-deficient mice
BackgroundPerilipin 5 (Plin5) is well known to maintain the stability of intracellular lipid droplets (LDs) and regulate fatty acid metabolism in...
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(R/S)-lactate/2-hydroxybutyrate dehydrogenases in and biosynthesis of block copolyesters by Ralstonia eutropha
AbstractBacterial polyhydroxyalkanoates (PHAs) are promising bio-based biodegradable polyesters. It was recently reported that novel PHA block...
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The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect
Aerobic glycolysis in cancer cells, also known as the ‘Warburg effect’, is driven by hyperactivity of lactate dehydrogenase A (LDHA). LDHA is thought...
