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  1. Label-Free Quantitation of Endogenous Peptides

    Liquid chromatography–mass spectrometry (LC-MS)-based peptidomics methods allow for the detection and identification of many peptides in a complex...
    Md Shadman Ridwan Abid, Haowen Qiu, James W. Checco in Peptidomics
    Protocol 2024
  2. Label-free Brillouin endo-microscopy for the quantitative 3D imaging of sub-micrometre biology

    This report presents an optical fibre-based endo-microscopic imaging tool that simultaneously measures the topographic profile and 3D viscoelastic...

    Salvatore La Cavera III, Veeren M. Chauhan, ... Matt Clark in Communications Biology
    Article Open access 15 April 2024
  3. Permittivity tensor imaging: modular label-free imaging of 3D dry mass and 3D orientation at high resolution

    The dry mass and the orientation of biomolecules can be imaged without a label by measuring their permittivity tensor (PT), which describes how...

    Li-Hao Yeh, Ivan E. Ivanov, ... Shalin B. Mehta in Nature Methods
    Article Open access 18 June 2024
  4. TPpred-LE: therapeutic peptide function prediction based on label embedding

    Background

    Therapeutic peptides play an essential role in human physiology, treatment paradigms and bio-pharmacy. Several computational methods have...

    Hongwu Lv, Ke Yan, Bin Liu in BMC Biology
    Article Open access 31 October 2023
  5. Label-free morpho-molecular phenoty** of living cancer cells by combined Raman spectroscopy and phase tomography

    Accurate, rapid and non-invasive cancer cell phenoty** is a pressing concern across the life sciences, as standard immuno-chemical imaging and...

    Arianna Bresci, Koseki J. Kobayashi-Kirschvink, ... Jeon Woong Kang in Communications Biology
    Article Open access 29 June 2024
  6. Label-free nanoscale map** of intracellular organelle chemistry

    The ability to image cell chemistry at the nanoscale is key for understanding cell biology, but many optical microscopies are restricted by the...

    George E. Greaves, Darya Kiryushko, ... Chris C. Phillips in Communications Biology
    Article Open access 31 May 2023
  7. Vibrational spectroscopy and multiphoton microscopy for label-free visualization of nervous system degeneration and regeneration

    Neurological disorders, including spinal cord injury, peripheral nerve injury, traumatic brain injury, and neurodegenerative diseases, pose...

    Roberta Galli, Ortrud Uckermann in Biophysical Reviews
    Article Open access 05 October 2023
  8. Quartet protein reference materials and datasets for multi-platform assessment of label-free proteomics

    Background

    Quantitative proteomics is an indispensable tool in life science research. However, there is a lack of reference materials for evaluating...

    Sha Tian, Dongdong Zhan, ... Chen Ding in Genome Biology
    Article Open access 07 September 2023
  9. EVATOM: an optical, label-free, machine learning assisted embryo health assessment tool

    The combination of a good quality embryo and proper maternal health factors promise higher chances of a successful in vitro fertilization (IVF)...

    Neha Goswami, Nicola Winston, ... Gabriel Popescu in Communications Biology
    Article Open access 05 March 2024
  10. Consumer preference for label presentations of freshness, taste, and serving suggestion on fresh fish packages of Japanese flounder Paralichthys olivaceus

    Understanding consumer choice behavior for seafood is important for the efficient and sustainable use of marine resources and the improvement of...

    Ryutaro Kamiyama, Hiroki Wakamatsu, ... Kenji Ishihara in Fisheries Science
    Article 06 April 2024
  11. Autofluorescence Label-Free Imaging of the Liver Reticular Structure

    AutofluorescenceAutofluorescence rising from biological substrates under proper excitation light depends on the presence of specific endogenous...
    Anna C. Croce, Giuseppina Palladini, ... Mariapia Vairetti in Histochemistry of Single Molecules
    Protocol 2023
  12. DNA as Hereditary Material

    The relative simplicity of the structure of deoxyribonucleic acid (DNA) and the complexity of inheritance led to the assumption that DNA was not the...
    Hernán Eduardo Laurentin Táriba in Agricultural Genetics
    Chapter 2023
  13. 4D label-free proteomics analysis of oxygen-induced retinopathy with or without anti-VEGF treatment

    Oxygen-induced retinopathy (OIR) animal model is widely used for retinopathy of prematurity (ROP) researches. The purpose of this study was to...

    Zhaokai Xu, Yubo Wu, ... Lijun Shen in BMC Genomics
    Article Open access 26 April 2024
  14. In situ label-free X-ray imaging for visualizing the localization of nanomedicines and subcellular architecture in intact single cells

    Understanding the intracellular behaviors of nanomedicines and morphology variation of subcellular architecture impacted by nanomaterial–biology...

    Ming**g Cao, Yaling Wang, ... Chunying Chen in Nature Protocols
    Article 13 November 2023
  15. msmsEDA & msmsTests: Label-Free Differential Expression by Spectral Counts

    msmsTests is an R/Bioconductor package providing functions for statistical tests in label-free LC-MS/MS data by spectral counts. These functions aim...
    Josep Gregori, Àlex Sánchez, Josep Villanueva in Statistical Analysis of Proteomic Data
    Protocol 2023
  16. Validation of MS/MS Identifications and Label-Free Quantification Using Proline

    In the proteomics field, the production and publication of reliable mass spectrometry (MS)-based label-free quantitative results is a major concern....
    Véronique Dupierris, Anne-Marie Hesse, ... Christophe Bruley in Statistical Analysis of Proteomic Data
    Protocol 2023
  17. Transplanted human photoreceptors transfer cytoplasmic material but not to the recipient mouse retina

    Background

    The discovery of material transfer between transplanted and host mouse photoreceptors has expanded the possibilities for utilizing...

    Margaret T. Ho, Kotoe Kawai, ... Molly S. Shoichet in Stem Cell Research & Therapy
    Article Open access 14 March 2024
  18. Material category of visual objects computed from specular image structure

    Recognizing materials and their properties visually is vital for successful interactions with our environment, from avoiding slippery floors to...

    Alexandra C. Schmid, Pascal Barla, Katja Doerschner in Nature Human Behaviour
    Article Open access 29 June 2023
  19. Structural characterization of protein-material interfacial interactions using lysine reactivity profiling-mass spectrometry

    Understanding how proteins and materials interact is useful for evaluating the safety of biomedical micro/nanomaterials, toxicity estimation and...

    Zheyi Liu, Shirui Yang, ... Fangjun Wang in Nature Protocols
    Article 17 July 2023
  20. LIVECell—A large-scale dataset for label-free live cell segmentation

    Light microscopy combined with well-established protocols of two-dimensional cell culture facilitates high-throughput quantitative imaging to study...

    Christoffer Edlund, Timothy R. Jackson, ... Rickard Sjögren in Nature Methods
    Article Open access 30 August 2021
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