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Protein kinase D2-Aurora kinase A-ERK1/2 signalling axis drives neuroendocrine differentiation of epithelial ovarian cancer
Epithelial ovarian cancer (EOC) is deadliest gynecological malignancy with poor prognosis and patient survival. Despite development of several...
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Develo** a Kinase Chemogenomic Set: Facilitating Investigation into Kinase Biology by Linking Phenotypes to Targets
Advances in increasingly complex phenotypic screening with lower throughput have necessitated the screening of smaller more highly annotated sets....
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Large-scale analysis of the N-terminal regulatory elements of the kinase domain in plant Receptor-like kinase family
BackgroundThe N-terminal regulatory element (NRE) of Receptor-like kinases (RLKs), consisting of the juxtamembrane segment in receptor kinases (RKs)...
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A Method for Screening a Kinase Inhibitor Drug Library on ASCs
Breast cancer is an ongoing issue due to its high mortality rates. Obesity enhances the problems associated with breast cancer, meaning there must be...
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Screening Kinase-Dependent Phosphorylation of Key Metabolic Reprogramming Regulators
Aerobic glycolysis has been commonly linked to cell proliferation, especially in cancer cells where it serves to generate sufficient energy and...
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Dissecting the Multiple Functions of the Polo-Like Kinase 1 in the C. elegans Zygote
Plk1 (polo-like kinase 1) is an evolutionarily conserved serine/threonine kinase instrumental for mitotic entry and progression. Beyond these...
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Kinase inhibitor pulldown assay (KiP) for clinical proteomics
Protein kinases are frequently dysregulated and/or mutated in cancer and represent essential targets for therapy. Accurate quantification is...
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Emerging trends in IRAK-4 kinase research
The IRAK-4 kinase lies at a critical signaling node that drives cancer cell survival through multiple mechanisms, activation, and translocation of...
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In Vitro Kinase Assay with Recombinant SnRK2s: An Example for Assaying Stress-Responsive Kinases in Plants
Protein phosphorylation is one of the most important posttranslational modifications in cell signaling pathways. Kinases and phosphatases play...
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Genome-wide identification of the mitogen-activated protein kinase kinase kinase (MAPKKK) in pear (Pyrus bretschneideri) and their functional analysis in response to black spot
Main conclusionIdentification of MAPKKK genes in pear and functional characterization of PbrMAPKKK82 in response to pear black spot.
Abstract ...
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The Role of Aurora B Kinase in Normal and Cancer Cells
AbstractAurora kinases are essential players in mammalian cell division. These kinases are involved in the regulation of spindle dynamics,...
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The Glycine Max Abscisic Acid-Activated Protein Kinase-Like Kinase 1 (GmAALK1) Modulates Drought Stress Response
Abscisic acid-activated protein kinases (AAPK) are key components in abscisic acid (ABA) signalling and have been implicated in mediating responses...
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NanoBRET™ Live-Cell Kinase Selectivity Profiling Adapted for High-Throughput Screening
Kinases represent one of the most therapeutically tractable targets for drug discovery in the twenty-first century. However, confirming engagement...
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The sucrose non-fermenting-1 kinase Snf1 is involved in fludioxonil resistance via interacting with the high osmolarity glycerol MAPK kinase Hog1 in Fusarium
Fusarium head blight (FHB) caused by Fusarium graminearum complex is a worldwide devastating disease of wheat, barley, maize, and other cereals. In...
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Human DNA-dependent protein kinase activation mechanism
DNA-dependent protein kinase (DNA-PK), a multicomponent complex including the DNA-PK catalytic subunit and Ku70/80 heterodimer together with DNA, is...
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Kaposi’s sarcoma-associated herpesvirus viral protein kinase augments cell survival
Oncogenic viruses have developed various strategies to antagonize cell death and maintain lifelong persistence in their host, a relationship that may...
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Apoptosis signal-regulating kinase 1 promotes inflammation in senescence and aging
Cellular senescence is a stress-induced, permanent cell cycle arrest involved in tumor suppression and aging. Senescent cells secrete bioactive...
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Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ
The conversion of phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 3,4,5-triphosphate by phosphoinositide 3-kinase γ (PI3Kγ) is critical...
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Deploying Kinase Inhibitors to Study Pediatric Gliomas
Pediatric midline gliomas are a uniformly fatal disease for which there is no cure. The location of these tumors makes surgical resection impossible,...
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Functions of the RIP kinase family members in the skin
The receptor interacting protein kinases (RIPK) are a family of serine/threonine kinases that are involved in the integration of various stress...
