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Nrf2 activation: a key mechanism in stem cell exosomes-mediated therapies
Exosomes are nano-sized membrane extracellular vesicles which can be released from various types of cells. Exosomes originating from inflammatory or...
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Chlorophyll fluorometry in evaluating photosynthetic performance: key limitations, possibilities, perspectives and alternatives
Non-destructive methods for the assessment of photosynthetic parameters of plants are widely applied to evaluate rapidly the photosynthetic...
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Regulation of Plant Responses to Temperature Stress: A Key Factor in Food Security and for Mitigating Effects of Climate Change
Among the many threats to food security, extremes of temperature, and unpredictable changes in temperature such as unseasonal frost or snowfall...
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Calcium signaling in neurodevelopment and pathophysiology of autism spectrum disorders
BackgroundAutism spectrum disorder (ASD) covers a group of neurodevelopmental disorders with complex genetic background. Several genetic mutations,...
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In silico analysis of key regulatory networks related to microfibril angle in Populus trichocarpa Hook.
Dissection of regulatory network that control wood structure is highly challenging in functional genomics. Nevertheless, due to the availability of...
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Insight into the underlying molecular mechanism of dilated cardiomyopathy through integrative analysis of data mining, iTRAQ-PRM proteomics and bioinformatics
BackgroundDCM is a common cardiomyopathy worldwide, which is characterized by ventricular dilatation and systolic dysfunction. DCM is one of the most...
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Mitochondrial proteome research: the road ahead
Mitochondria are multifaceted organelles with key roles in anabolic and catabolic metabolism, bioenergetics, cellular signalling and nutrient...
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Mitochondrial mechanisms in the pathogenesis of chronic inflammatory musculoskeletal disorders
Chronic inflammatory musculoskeletal disorders characterized by prolonged muscle inflammation, resulting in enduring pain and diminished...
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Mitofusins: from mitochondria to fertility
Germ cell formation and embryonic development require ATP synthesized by mitochondria. The dynamic system of the mitochondria, and in particular, the...
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Copper in Cancer: from transition metal to potential target
In recent years, with the continuous in-depth exploration of the molecular mechanisms of tumorigenesis, numerous potential new targets for cancer...
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Defective Mitophagy and the Etiopathogenesis of Alzheimer’s Disease
As far as dementia goes, Alzheimer’s disease (AD) is the most prevalent. The disease is gradual, starting with mild memory loss and potentially...
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Directed proton transfer from Fo to F1 extends the multifaceted proton functions in ATP synthase
The role of protons in ATP synthase is typically considered to be energy storage in the form of an electrochemical potential, as well as an operating...
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Chitosan functionalized Mn3O4 nanoparticles counteracts ulcerative colitis in mice through modulation of cellular redox state
Recent findings suggest a key role for reactive oxygen species (ROS) in the pathogenesis and progression of ulcerative colitis (UC). Several studies...
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Different types of cell death and their shift in sha** disease
Cell death is the irreversible stop of life. It is also the basic physiological process of all organisms which involved in the embryonic development,...
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Crop Physiology and Biotechnology
Plant physiology has significantly contributed to the feeding of human beings. Applications of our knowledge of key concepts and processes in plant...
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Metabolic profile of mesenchymal stromal cells and macrophages in the presence of polyethylene particles in a 3D model
BackgroundContinuous cross talk between MSCs and macrophages is integral to acute and chronic inflammation resulting from contaminated polyethylene...
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Plant System Biology
Modern systems biology emerged owing to the necessity to translate the massive amounts of data produced by genome-scale investigations into...
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A small protein coded within the mitochondrial canonical gene nd4 regulates mitochondrial bioenergetics
BackgroundMitochondria have a central role in cellular functions, aging, and in certain diseases. They possess their own genome, a vestige of their...
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Chemiosmosis and Modern Symbioses
Why should individuals of two different species cooperate? In evolutionary terms, cooperation usually involves costs and thus is not an automatic...
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The Role of Sestrins in the Regulation of the Cellular Response to Stress
AbstractThis review is devoted to the analysis of proteins of the sestrin family and their role in the response of cells to stress. The paper...
