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Biogenesis of specialized lysosomes in differentiated keratinocytes relies on close apposition with the Golgi apparatus
Intracellular organelles support cellular physiology in diverse conditions. In the skin, epidermal keratinocytes undergo differentiation with gradual...
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In vitro generation of epidermal keratinocytes from human CD34-positive hematopoietic stem cells
The epidermis is largely composed of keratinocytes (KCs), and the proliferation and differentiation of KCs from the stratum basale to the stratum...
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TRPV3-ANO1 interaction positively regulates wound healing in keratinocytes
Transient receptor potential vanilloid 3 (TRPV3) belongs to the TRP ion channel super family and functions as a nonselective cation channel that is...
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Intracellular Mg2+ protects mitochondria from oxidative stress in human keratinocytes
Reactive oxygen species (ROS) are harmful for the human body, and exposure to ultraviolet irradiation triggers ROS generation. Previous studies have...
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Single-cell sequencing reveals increased LAMB3-positive basal keratinocytes and ZNF90-positive fibroblasts in autologous cultured epithelium
Autologous cultured epithelium grafting (ACEG) presents a promising treatment for refractory vitiligo, yet concerns regarding infections and...
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Gasdermin E promotes translocation of p65 and c-jun into nucleus in keratinocytes for progression of psoriatic skin inflammation
Gasdermin E (GSDME) has recently been identified as a critical executioner to mediate pyroptosis. While epidermal keratinocytes can initiate...
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Melanoma stimulates the proteolytic activity of HaCaT keratinocytes
BackgroundKeratinocytes constitute a major part of the melanoma microenvironment, considering their protective role towards melanocytes in...
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A Systematic Review of Stem Cell Differentiation into Keratinocytes for Regenerative Applications
To improve wound healing or treatment of other skin diseases, and provide model cells for skin biology studies, in vitro differentiation of stem...
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METTL14-upregulated miR-6858 triggers cell apoptosis in keratinocytes of oral lichen planus through decreasing GSDMC
Oral lichen planus (OLP), a chronic inflammatory disorder, is characterized by the massive cell apoptosis in the keratinocytes of oral mucosa....
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Mitophagy associated self-degradation of phosphorylated MAP4 guarantees the migration and proliferation responses of keratinocytes to hypoxia
Our previous study has announced that phosphorylated microtubule-associated protein 4 (p-MAP4) accelerated keratinocytes migration and proliferation...
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SOX4 reversibly induces phenotypic changes by suppressing the epithelial marker genes in human keratinocytes
BackgroundSOX4 is a transcription factor belonging to the SOX (Sry-related High Mobility Group [HMG] box) family and plays a pivotal role in various...
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Oral Biofilm Composition, Dissemination to Keratinocytes, and Inflammatory Attenuation Depend on Probiotic and Synbiotic Strain Specificity
Several inflammatory diseases are characterized by a disruption in the equilibrium between the host and its microbiome. Due to the increase in...
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Paracrine signalling between keratinocytes and SVF cells results in a new secreted cytokine profile during wound closure
Stromal vascular fraction (SVF) cells, and the adipose-derived mesenchymal stem cells they contain, have shown enhanced wound healing in vitro and in...
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Metabolomics analysis reveals cytotoxic effects of ouabain towards psoriatic keratinocytes via impairment of glutathione metabolism
Ouabain is a cardiac glycoside long studied for treating heart diseases, but the attempts to evaluate its anti-psoriatic activity have not been...
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Dyslipidemia initiates keratinocytes proliferation through upregulation of lncRNA NEAT in psoriasis patients
BackgroundPsoriasis is a chronic inflammatory immune-mediated and hyper proliferative skin disorder that has underlying genetic factors. Psoriasis...
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Characterisation of cytotoxicity and immunomodulatory effects of glycolipid biosurfactants on human keratinocytes
AbstractSkin irritation and allergic reactions associated with the use of skincare products formulated with synthetically derived surfactants such as...
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Single-cell integrated transcriptomics reveals the role of keratinocytes in head and neck squamous cell carcinoma
Head and neck squamous cell carcinoma (HNSCC) is a prevalent malignant tumor with significant morbidity and mortality. Understanding the molecular...
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MicroRNA-221-3p inhibits the inflammatory response of keratinocytes by regulating the DYRK1A/STAT3 signaling pathway to promote wound healing in diabetes
Diabetic foot ulcer (DFU), a serious complication of diabetes, remains a clinical challenge. MicroRNAs affect inflammation and may have therapeutic...
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Low humidity altered the gene expression profile of keratinocytes in a three-dimensional skin model
BackgroundThe skin is constantly exposed to various external stimuli including humidity variations. Low humidity affects skin properties such as...
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Cutaneous nerve fibers participate in the progression of psoriasis by linking epidermal keratinocytes and immunocytes
Recent studies have illustrated that psoriatic lesions are innervated by dense sensory nerve fibers. Psoriatic plaques appeared to improve after...
