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Negative regulation of pro-apoptotic AMPK/JNK pathway by itaconate in mice with fulminant liver injury
Accumulating evidence indicates that metabolic responses are deeply integrated into signal transduction, which provides novel opportunities for the...
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Selenium-Chitosan Protects Porcine Endometrial Epithelial Cells from Zearalenone-induced Apoptosis via the JNK/SAPK Signaling Pathway
This study was designed to assess whether selenium-chitosan (Se-CTS) can protect porcine endometrial epithelial cells (PEECs) against damage and...
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NUMA1 modulates apoptosis of esophageal squamous cell carcinoma cells through regulating ASK1-JNK signaling pathway
Esophageal squamous cell carcinoma (ESCC) is a common malignancy worldwide with a low survival rate due to a lack of therapeutic targets. Here, our...
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Modulatory apoptotic effects of sinomenine on Mycoplasma pneumonia through the attenuation of inflammation via ERK/JNK/NF-κB signaling pathway
Mycoplasma pneumoniae (MPP) induced pneumonia is a common disease of children. Sinomenine (SIN) is an isoquinoline mainly sequestered from Sinomenium...
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Manipulating PP2Acα-ASK-JNK signaling to favor apoptotic over necroptotic hepatocyte fate reduces the extent of necrosis and fibrosis upon acute liver injury
In the widely used Carbon tetrachloride (CCl 4 )-induced acute liver injury (ALI) mouse model, hepatocytes are known to die from programmed cell death...
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Slik maintains tissue homeostasis by preventing JNK-mediated apoptosis
BackgroundThe c-Jun N-terminal kinase (JNK) pathway is an evolutionarily conserved regulator of cell death, which is essential for coordinating...
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p20BAP31 induces cell apoptosis via both AIF caspase-independent and the ROS/JNK mitochondrial pathway in colorectal cancer
BackgroundDuring cell apoptosis, the C-terminus of BAP31 is cleaved by caspase-8 and generates p20BAP31, which has been shown to induce an apoptotic...
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Regulator of calcineurin 1 deletion attenuates mitochondrial dysfunction and apoptosis in acute kidney injury through JNK/Mff signaling pathway
Ischemia-reperfusion (I/R) induced acute kidney injury (AKI), characterized by excessive mitochondrial damage and cell apoptosis, remains a clinical...
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Regulator of G protein signaling 16 restrains apoptosis in colorectal cancer through disrupting TRAF6-TAB2-TAK1-JNK/p38 MAPK signaling
Colorectal cancer (CRC) remains a major global cause of cancer-related mortality, lacking effective biomarkers and therapeutic targets. Revealing the...
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Zinc supplementation ameliorates sorafenib-induced cognitive impairment through ROS/JNK signaling pathway
Sorafenib, a multiple kinase inhibitor, is widely used in cancer patients. Recently, clinical studies highlighted the relationship between cognitive...
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GCN5-mediated regulation of pathological cardiac hypertrophy via activation of the TAK1-JNK/p38 signaling pathway
Pathological cardiac hypertrophy is a process of abnormal remodeling of cardiomyocytes in response to pressure overload or other stress stimuli,...
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GPER deletion triggers inhibitory effects in triple negative breast cancer (TNBC) cells through the JNK/c-Jun/p53/Noxa transduction pathway
The G protein-coupled estrogen receptor (GPER) mediates estrogen action in different pathophysiological conditions, including cancer. GPER expression...
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Oxidative Stress-Induced Platelet Apoptosis/Activation: Alleviation by Purified Curcumin via ASK1-JNK/p-38 Pathway
AbstractPlatelets are known for their indispensable role in hemostasis and thrombosis. However, alteration in platelet function due to oxidative...
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RETRACTED ARTICLE: Hepatic stellate cell mediates transcription of TNFSF14 in hepatocellular carcinoma cells via H2S/CSE-JNK/JunB signaling pathway
Hepatic stellate cells (HSC) and hydrogen sulfide (H 2 S) both play important roles in the development of hepatocellar carcinoma (HCC). Whereas, in the...
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Biphasic JNK signaling reveals distinct MAP3K complexes licensing inflammasome formation and pyroptosis
Kinase signaling in the tiered activation of inflammasomes and associated pyroptosis is a prime therapeutic target for inflammatory diseases. While...
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Intrinsic disorder in proteins associated with oxidative stress-induced JNK signaling
The c-Jun N-terminal kinase (JNK) signaling cascade is a mitogen-activated protein kinase (MAPK) signaling pathway that can be activated in response...
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Nanosized Titanium Dioxide Induced Apoptosis and Abnormal Expression of Blood-Testis Barrier Junction Proteins Through JNK Signaling Pathway in TM4 Cells
Nanosized titanium dioxide (nano-TiO 2 ) has been widely used in consumer products. It can cross the blood-testis barrier (BTB), and it has adverse...
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TBC1 domain family member 25 protects against myocardial apoptosis and the proinflammatory response triggered by ischemia–reperfusion injury through suppression of the TAK1-JNK/p38 MAPK signaling cascade
TBC1 domain family member 25 (TBC1D25) is a crucial mediator of signal transduction involved in the development of several diseases. Particularly, a...
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Usp8 promotes tumor cell migration through activating the JNK pathway
Tumor metastasis is the most cause of high mortality for cancer patients. Identification of novel factors that modulate tumor cell migration is of...
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MAPK Signaling Pathway Plays Different Regulatory Roles in the Effects of Boric Acid on Proliferation, Apoptosis, and Immune Function of Splenic Lymphocytes in Rats
Boron is one of the essential trace elements in animals. Although boron supplementation can enhance immune function and promote cell proliferation,...
