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HPV16 E7-impaired keratinocyte differentiation leads to tumorigenesis via cell cycle/pRb/involucrin/spectrin/adducin cascade
Here, we used codon usage technology to generate two codon-modified human papillomavirus (HPV)16 E7 genes and, together with wild-type E7, to...
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Comparative immunohistochemical analysis suggests a conserved role of EPS8L1 in epidermal and hair follicle barriers of mammals
The mammalian skin and its appendages depend on tightly coordinated differentiation of epithelial cells. Epidermal growth factor receptor (EGFR)...
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Bioengineered skin constructs based on mesenchymal stromal cells and acellular dermal matrix exposed to inflammatory microenvironment releasing growth factors involved in skin repair
BackgroundSkin tissue engineering is a rapidly evolving field of research that effectively combines stem cells and biological scaffolds to replace...
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Development of Hetero-Cell Type Spheroids Via Core–Shell Strategy for Enhanced Wound Healing Effect of Human Adipose-Derived Stem Cells
BACKGROUND:Stem cell-based therapies have been developed to treat various types of wounds. Human adipose-derived stem cells (hADSCs) are used to...
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Korean red ginseng extract exploits NF-κB to promote wound repair and protein expression in keratinocytes
BackgroundKeratinocytes are the primary cell type in the epidermis and play an essential role in protecting the body against external insults. To...
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Terminal differentiation of keratinocytes was damaged in type 2 diabetic mice
AimsAlthough skin manifestations are common in diabetic patients, its characteristics are poorly identified. This study explored the differentiation...
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Proteasomal degradation of p130 facilitate cell cycle deregulation and impairment of cellular differentiation in high-risk Human Papillomavirus 16 and 18 E7 transfected cells
The High-Risk Human Papillomaviruses (HR-HPVs) 16 and 18 are known to cause cervical cancer, which is primarily attributed to E6 and E7 oncoproteins....
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A Systematic Review of Stem Cell Differentiation into Keratinocytes for Regenerative Applications
To improve wound healing or treatment of other skin diseases, and provide model cells for skin biology studies, in vitro differentiation of stem...
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Bioengineered MSCCxcr2 transdifferentiated keratinocyte-like cell-derived organoid potentiates skin regeneration through ERK1/2 and STAT3 signaling in diabetic wound
Skin regeneration is severely compromised in diabetic foot ulcers. Allogeneic mesenchymal stem cell (MSC) transplantation is limited due to the poor...
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DNA damage triggers squamous metaplasia in human lung and mammary cells via mitotic checkpoints
Epithelial transdifferentiation is frequent in tissue hyperplasia and contributes to disease in various degrees. Squamous metaplasia (SQM) precedes...
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Transglutaminase 3 regulates cutaneous squamous carcinoma differentiation and inhibits progression via PI3K-AKT signaling pathway-mediated Keratin 14 degradation
Cutaneous squamous carcinoma is the second most common epithelial malignancy, associated with significant morbidity, mortality, and economic burden....
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Natural alternatives targeting psoriasis pathology and key signaling pathways: a focus on phytochemicals
Psoriasis is an autoimmune, chronic skin disorder with complex and yet unclear pathogenesis. It is associated with many conditions, including...
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Down-regulation of peptidylarginine deiminase type 1 in reconstructed human epidermis disturbs nucleophagy in the granular layer and affects barrier function
Deimination is a post-translational modification catalyzed by a family of enzymes named peptidylarginine deiminases (PADs). PADs transform arginine...
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FBP1 orchestrates keratinocyte proliferation/differentiation and suppresses psoriasis through metabolic control of histone acetylation
Keratinocyte proliferation and differentiation in epidermis are well-controlled and essential for reacting to stimuli such as ultraviolet light....
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Use of mouse primary epidermal organoids for USA300 infection modeling and drug screening
Skin infections caused by drug-resistant Staphylococcus aureus occur at high rates nationwide. Mouse primary epidermal organoids (mPEOs) possess...
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Nacre Extract from Pearl Oyster Shell Prevents D-Galactose-Induced Brain and Skin Aging
Pearl oyster shells comprise two layers, a prismatic and nacreous layer, of calcium carbonate. The nacreous layer has been used in Chinese medicine...
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Gradual differentiation uncoupled from cell cycle exit generates heterogeneity in the epidermal stem cell layer
Highly regenerative tissues continuously produce terminally differentiated cells to replace those that are lost. How they orchestrate the complex...
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DNA damage signalling histone H2AX is required for tumour growth
Cancer most frequently develops in self-renewal tissues that are the target of genetic alterations due to mutagens or intrinsic DNA replication...
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Protective effect of Bifidobacterium animalis CGMCC25262 on HaCaT keratinocytes
Bifidobacteria are the most prevalent members of the intestinal microbiota in mammals and other animals, and they play a significant role in...
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Smurf2-induced degradation of SMAD2 causes inhibition of hair follicle stem cell differentiation
Hair follicle stem cells (HFSCs) are implicated in the formation of hair follicles and epidermis. This study aims to clarify the role of SMAD2 in...
