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Metabolite signaling in the heart
The heart is the most metabolically active organ in the body, sustaining a continuous and high flux of nutrient catabolism via oxidative...
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Secondary Metabolite Production in Medicinal Plants under Abiotic Stress
Like other plants, medicinal and aromatic plants have evolved several mechanisms to accommodate themselves under changing environmental conditions,...
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Predicting intercellular communication based on metabolite-related ligand-receptor interactions with MRCLinkdb
BackgroundMetabolite-associated cell communications play critical roles in maintaining human biological function. However, most existing tools and...
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Cholesterol neutralized vemurafenib treatment by promoting melanoma stem-like cells via its metabolite 27-hydroxycholesterol
Vemurafenib has been used as first-line therapy for unresectable or metastatic melanoma with BRAFV600E mutation. However, overall survival is still...
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Crispr Gene Editing for Secondary Metabolite Production: A Review
A variety of secondary metabolites or so-called phyto-metabolites with different biological properties and structures can be produced by medicinal...
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Metabolite interactions in the bacterial Calvin cycle and implications for flux regulation
Metabolite-level regulation of enzyme activity is important for microbes to cope with environmental shifts. Knowledge of such regulations can also...
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Metabolite itaconate in host immunoregulation and defense
Metabolic states greatly influence functioning and differentiation of immune cells. Regulating the metabolism of immune cells can effectively...
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Advanced Systems and Bioreactors for Large-Scale Secondary Metabolite Production in Medicinal Plants Using Suspension Cultured Cells
In recent years, there has been extensive research on large-scale plant secondary metabolite production systems and bioreactors for various...
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Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibition
The gut microbiota play a pivotal role in human health. Emerging evidence indicates that gut microbes participate in the progression of tumorigenesis...
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Aromatic secondary metabolite production from glycerol was enhanced by amino acid addition in Pichia pastoris
AbstractAromatic secondary metabolites are widely used in various industries, including the nutraceutical, dietary supplement, and pharmaceutical...
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Altered metabolomic states elicited by Flg22 and FlgII-28 in Solanum lycopersicum: intracellular perturbations and metabolite defenses
BackgroundSurveillance of potential pathogens is a key feature of plant innate immunity. For non-self-recognition plants rely on the perception of...
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A novel method to detect intracellular metabolite alterations in MCF-7 cells by doxorubicin induced cell death
BackgroundMetabolic reprogramming within cancer cells has been recognized as a potential barrier to chemotherapy. Additionally, metabolic tumor...
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Secondary metabolite gene clusters from the phytopathogenic fungus Gaeumannomyces tritici
The take-all disease is one of the most important maladies in cereals and grasses, being caused by the fungus Gaeumannomyces tritici . Secondary...
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Mannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P
Pyroptosis is a type of regulated cell death executed by gasdermin family members. However, how gasdermin-mediated pyroptosis is negatively regulated...
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Metabolite Effect on Angiogenesis: Insights from Transcriptome Analysis
Metabolic status of the cells is important in the expression of the angiogenic phenotype in endothelial cells. Our earlier studies demonstrated the...
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A cell-free strategy for host-specific profiling of intracellular antibiotic sensitivity and resistance
Antimicrobial resistance (AMR) is a pandemic spread across multiple infectious disease-causing microbes. To provide a host-specific tool to study...
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Impact of hypoxia and reoxygenation on the extra/intracellular metabolome and on transporter expression in a human kidney proximal tubular cell line
IntroductionIschemia-reperfusion injury (IRI) induces several perturbations that alter immediate kidney graft function after transplantation and may...
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Orientia tsutsugamushi: An Unusual Intracellular Bacteria—Adaptation Strategies, Available Antibiotics, and Alternatives for Treatment
During evolution Orientia tsutsugamushi became a smarter obligate bacterium to establish as intracellular pathogens. O. tsutsugamushi is a human...
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Noaoxazole, a new heat shock metabolite produced by thermotolerant Streptomyces sp. HR41
The thermotolerant strain Streptomyces sp. HR41 was found to produce compound 1 only in a 45 °C culture, and not at the standard temperature. We...
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Induction of in vitro shoots in Liverwort Acrolejeunea fertilis (Reinw., Blume & Nees) Schiffn. Gametophyte explants and their comparative metabolite and Bioactivity Analysis
Plant-derived natural products, including those from bryophytes, are particularly advantageous in several aspects, such as for their antifungal,...
