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1. STING signaling in islet macrophages impairs insulin secretion in obesity

   The innate immune regulator stimulator of interferon genes (STING) mediates self-DNA sensing and leads to the induction of type I interferons and...

   Ze Hong, Saihua Chen, ... Chen Wang in Science China Life Sciences

   Article 25 October 2023

2. Amino acid-stimulated insulin secretion: a path forward in type 2 diabetes

   Qualitative and quantitatively appropriate insulin secretion is essential for optimal control of blood glucose. Beta-cells of the pancreas produce...

   Jelena Kolic, WenQing Grace Sun, ... Nicola Guess in Amino Acids

   Article 15 November 2023
   

3. (+)-Catechin mitigates impairment in insulin secretion and beta cell damage in methylglyoxal-induced pancreatic beta cells

   Background

   The formation of advanced glycation end products (AGEs) is the central process contributing to diabetic complications in diabetic...

   Nair Anaga, Krishnan Lekshmy, Jayamurthy Purushothaman in Molecular Biology Reports

   Article 23 March 2024
   

4. Readily releasable β cells with tight Ca²⁺–exocytosis coupling dictate biphasic glucose-stimulated insulin secretion

   Biphasic glucose-stimulated insulin secretion (GSIS) is essential for blood glucose regulation, but a mechanistic model incorporating the recently...

   **aohong Peng, Huixia Ren, ... Liangyi Chen in Nature Metabolism

   Article 26 January 2024
   

5. Role of microRNAs in regulation of insulin secretion and insulin signaling involved in type 2 diabetes mellitus

   Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder due to insulin resistance that can be caused by both genetic and environmental...

   Angel Mendonca, Prabu Thandapani, ... Sujatha Sundaresan in Journal of Biosciences

   Article 14 September 2022
   

6. Short-chain fatty acids: possible regulators of insulin secretion

   The benefits of gut microbiota-derived short-chain fatty acids (SCFAs) towards health and metabolism have been emerging since the past decade....

   Nur Suraya Ashikin Rosli, Shafinaz Abd Gani, ... Mohd Badrin Hanizam Abdul Rahim in Molecular and Cellular Biochemistry

   Article 09 August 2022
   

7. Participation of Magnesium in the Secretion and Signaling Pathways of Insulin: an Updated Review

   Several studies have demonstrated the participation of various minerals in mechanisms involving insulin. Magnesium, in particular, plays an important...

   Stéfany Rodrigues de Sousa Melo, Loanne Rocha dos Santos, ... Dilina do Nascimento Marreiro in Biological Trace Element Research

   Article 06 June 2022
   

8. Functionally heterogeneous β cells regulate biphasic insulin secretion

   in Nature Metabolism

   Article 26 January 2024
   

9. A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes

   The pancreatic islets are composed of discrete hormone-producing cells that orchestrate systemic glucose homeostasis. Here we identify subsets of...

   Alfonso Rubio-Navarro, Nicolás Gómez-Banoy, ... James C. Lo in Nature Cell Biology

   Article 16 March 2023
   

10. Vanillic acid potentiates insulin secretion and prevents pancreatic β-cells cytotoxicity under H₂O₂-induced oxidative stress

    Background

    Oxidative stress is known to impair cellular functions and, therefore, plays a significant role in the pathophysiology of various diseases,...

    Chandan Muddahally Naganna, K. Yogendra Prasad, ... Ravi Kumar in Molecular Biology Reports

    Article 01 December 2022
    

11. Waxy lipids and waning insulin secretion

    Jonathan S. Bogan in Nature Cell Biology

    Article 21 December 2022
    

12. GLP-1 signaling-regulated SNAP25 is involved in improved insulin secretion in diabetic GK rats after Roux-en-Y gastric bypass surgery

    Background

    Roux-en-Y gastric bypass surgery (RYGB) improves glucose-stimulated insulin secretion (GSIS) in type 2 diabetes (T2D) patients. SNAP25...

    **angchen Kong, Chao Lin, ... **aosong Ma in Molecular Biology Reports

    Article 16 January 2024
    

13. Cancer-cell-secreted extracellular vesicles suppress insulin secretion through miR-122 to impair systemic glucose homeostasis and contribute to tumour growth

    Epidemiological studies demonstrate an association between breast cancer (BC) and systemic dysregulation of glucose metabolism. However, how BC...

    Minghui Cao, Roi Isaac, ... Shizhen Emily Wang in Nature Cell Biology

    Article 30 May 2022
    

14. β-Klotho promotes glycolysis and glucose-stimulated insulin secretion via GP130

    Impaired glucose-stimulated insulin secretion (GSIS) is a hallmark of type-2 diabetes. However, cellular signaling machineries that control GSIS...

    Leiluo Geng, Boya Liao, ... Aimin Xu in Nature Metabolism

    Article 12 May 2022
    

15. iPSCs derived from insulin resistant offspring of type 2 diabetic patients show increased oxidative stress and lactate secretion

    Background

    The genetic factors associated with insulin resistance (IR) are not well understood. Clinical studies on first-degree relatives of type 2...

    Bushra Memon, Ahmed K. Elsayed, ... Essam M. Abdelalim in Stem Cell Research & Therapy

    Article Open access 20 August 2022
    

16. The Effect of Sitagliptin and Exenatide on Insulin, Insulin Receptor and Insulin Receptor Substrate Gene Expression in Diabetic Rats

    Abstract

    Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia that results from abnormal secretion of insulin,...

    M. Yildirim, O. Agtas Mistik, ... S. Yalin in Russian Journal of Bioorganic Chemistry

    Article 11 May 2023
    

17. Excessive iron inhibits insulin secretion via perturbing transcriptional regulation of SYT7 by OGG1

    Although iron overload is closely related to the occurrence of type 2 diabetes mellitus (T2DM), the specific mechanism is unclear. Here, we found...

    **ngqi Zhao, Ying Ma, ... Zhigang Guo in Cellular and Molecular Life Sciences

    Article 20 May 2023
    

18. Gallic Acid and Gallic Acid Nanoparticle Modulate Insulin Secretion Pancreatic β-Islets against Silica Nanoparticle–Induced Oxidative Damage

    Due to the increasing use of silica nanoparticles (SiNPs), their possible toxic effects on human health have undoubtedly been considered. Previous...

    Akram Ahangarpour, Hassan Sharifinasab, ... Fereshteh Golfakhrabadi in Biological Trace Element Research

    Article 12 January 2022
    

19. KCNH6 channel promotes insulin exocytosis via interaction with Munc18-1 independent of electrophysiological processes

    Glucose-stimulated insulin secretion (GSIS) in pancreatic islet β-cells primarily relies on electrophysiological processes. Previous research...

    Hao Wang, Qi Li, ... **-Kui Yang in Cellular and Molecular Life Sciences

    Article Open access 13 February 2024
    

20. High-Throughput Screening for Insulin Secretion Modulators

    The application of forward chemical genetics to insulin secretion in high-throughput has been uncommon because of high costs and technical...

    Michael A. Kalwat in Exocytosis and Endocytosis

    Protocol 2021