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Potentiation of apoptosis in drug-resistant mantle cell lymphoma cells by MCL-1 inhibitor involves downregulation of inhibitor of apoptosis proteins
Bruton’s tyrosine kinase inhibitors (BTKi) and CAR T-cell therapy have demonstrated tremendous clinical benefits in mantle cell lymphoma (MCL)...
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TRAF2/3 deficient B cells resist DNA damage-induced apoptosis via NF-κB2/XIAP/cIAP2 axis and IAP antagonist sensitizes mutant lymphomas to chemotherapeutic drugs
Deletion of TRAF2 or TRAF3 in B cells prolongs their survival. However, it remains unknown whether deletion of such factors affects B cells’ ability...
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Interaction of LATS1 with SMAC links the MST2/Hippo pathway with apoptosis in an IAP-dependent manner
Metastatic malignant melanoma is the deadliest skin cancer, and it is characterised by its high resistance to apoptosis. The main melanoma driving...
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The expanded inhibitor of apoptosis gene family in oysters possesses novel domain architectures and may play diverse roles in apoptosis following immune challenge
BackgroundApoptosis plays important roles in a variety of functions, including immunity and response to environmental stress. The Inhibitor of...
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Multipronged regulation of autophagy and apoptosis: emerging role of TRIM proteins
TRIM proteins are characterized by their conserved N-terminal RING, B-box, and coiled-coil domains. These proteins are efficient regulators of...
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Inter-α-inhibitor Proteins: A Review of Structure and Function
Inter-α-inhibitor-family proteins (IAIP) are a multifaceted group of complex molecules with important roles in mammalian biology. In the past...
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Molecular basis for nuclear accumulation and targeting of the inhibitor of apoptosis BIRC2
The inhibitor of apoptosis protein BIRC2 regulates fundamental cell death and survival signaling pathways. Here we show that BIRC2 accumulates in the...
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Clinical stage drugs targeting inhibitor of apoptosis proteins purge episomal Hepatitis B viral genome in preclinical models
A major unmet clinical need is a therapeutic capable of removing hepatitis B virus (HBV) genome from the liver of infected individuals to reduce...
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miR-874-3p mitigates cisplatin resistance through modulating NF-κB/inhibitor of apoptosis protein signaling pathway in epithelial ovarian cancer cells
The resistance to cisplatin, the most common platinum chemotherapy drug, may confine the efficacy of treatment in epithelial ovarian cancer patients....
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Targeting the apoptosis pathway to treat tumours of the paediatric nervous system
New, more effective therapeutics are required for the treatment of paediatric cancers. Current treatment protocols of cytotoxic treatments including...
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Engorgement of Rhipicephalus haemaphysaloides ticks blocked by silencing a protein inhibitor of apoptosis
Inhibitors of apoptosis (IAPs) are regulators of cell death and may play a role in the salivary glands of ticks during blood-feeding. We cloned the...
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Pro-Inflammatory Activation Suppresses TRAIL-induced Apoptosis of Acute Myeloid Leukemia Cells
AbstractTumor necrosis factor-related apoptosis-inducing ligand (TRAIL/Apo2L) is a promising agent for treatment of AML due to its specific...
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Combination of bazedoxifene with chemotherapy and SMAC-mimetics for the treatment of colorectal cancer
Excessive STAT3 signalling via gp130, the shared receptor subunit for IL-6 and IL-11, contributes to disease progression and poor survival outcomes...
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How does caspases regulation play role in cell decisions? apoptosis and beyond
Caspases are a family of cysteine proteases, and the key factors behind the cellular events which occur during apoptosis and inflammation. However,...
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The deubiquitylating enzyme USP35 restricts regulated cell death to promote survival of renal clear cell carcinoma
The ubiquitin-proteasome system governs a wide spectrum of cellular events and offers therapeutic opportunities for pharmacological intervention in...
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The dual role of mesenchymal stem cells in apoptosis regulation
Mesenchymal stem cells (MSCs) are widely distributed pluripotent stem cells with powerful immunomodulatory capacity. MSCs transplantation therapy...
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Oxidative Stress, Endoplasmic Reticulum Stress and Apoptosis in the Pathology of Alzheimer’s Disease
Alzheimer’s disease (AD) accounts for a major statistic among the class of neurodegenerative diseases. A number of mechanisms have been identified in...
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Targeting cathepsin L in the regulation of apoptosis in peripheral T-cell lymphoma
BackgroundsPeripheral T-cell lymphoma (PTCL) is a heterogeneous lymphoproliferative neoplasms derived from post-thymic T lymphocytes and mature NK...
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When cell death goes wrong: inflammatory outcomes of failed apoptosis and mitotic cell death
Apoptosis is a regulated cellular pathway that ensures that a cell dies in a structured fashion to prevent negative consequences for the tissue or...
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Suppression of TBCK enhances TRAIL-mediated apoptosis by causing the inactivation of the akt signaling pathway in human renal carcinoma Caki-1 cells
BackgroundTBC1 domain-containing kinase (TBCK) protein functions as a growth suppressor in certain cell types and as a tumor promoter in others....
