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Autonomic nervous system imbalance during aging contributes to impair endogenous anti-inflammaging strategies
Inflammaging refers to the age-related low grade, sterile, chronic, systemic, and long-lasting subclinical, proinflammatory status, currently...
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Repetitive element transcript accumulation is associated with inflammaging in humans
Chronic, low-grade inflammation increases with aging, contributing to functional declines and diseases that reduce healthspan. Growing evidence...
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The companion dog as a model for inflammaging: a cross-sectional pilot study
Inflammaging, the chronic, progressive proinflammatory state associated with aging, has been associated with multiple negative health outcomes in...
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Reduced mitochondrial calcium uptake in macrophages is a major driver of inflammaging
Mitochondrial dysfunction is linked to age-associated inflammation or inflammaging, but underlying mechanisms are not understood. Analyses of 700...
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Probiotic-Reduced Inflammaging in Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial
The disparity between increased lifespan and healthy aging, marked by prevalent “inflammaging”, highlights the global challenge in care of older...
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Inflammaging in domestic dogs: basal level concentrations of IL-6, IL-1β, and TNF-α in serum of healthy dogs of different body sizes and ages
Inflammaging, a “hallmark of aging,” refers to a chronic, progressive increase in the proinflammatory status of mammals as they age, and this...
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CISH impairs lysosomal function in activated T cells resulting in mitochondrial DNA release and inflammaging
Chronic systemic inflammation is one of the hallmarks of the aging immune system. Here we show that activated T cells from older adults contribute to...
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Biomarkers of mitochondrial dysfunction and inflammaging in older adults and blood pressure variability
Most physiopathological mechanisms underlying blood pressure variability (BPV) are implicated in aging. Vascular aging is associated with chronic...
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Age-related cerebral small vessel disease and inflammaging
The continued increase in global life expectancy predicts a rising prevalence of age-related cerebral small vessel diseases (CSVD), which requires a...
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Senescent macrophages in the human adipose tissue as a source of inflammaging
Obesity is a major risk factor for type 2 diabetes and a trigger of chronic and systemic inflammation. Recent evidence suggests that an increased...
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Rapamycin restores brain vasculature, metabolism, and blood-brain barrier in an inflammaging model
Rapamycin (RAPA) is found to have neuro-protective properties in various neuroinflammatory pathologies, including brain aging. With magnetic...
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Contribution of senescent and reactive astrocytes on central nervous system inflammaging
Astrocytes, the most predominant cells in the central nervous system (CNS), have well-recognized neuroprotective functions. However, during the CNS...
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Inhibition of S6K lowers age-related inflammation and increases lifespan through the endolysosomal system
Suppression of target of rapamycin complex 1 (TORC1) by rapamycin ameliorates aging in diverse species. S6 kinase (S6K) is an essential mediator, but...
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Kidney inflammaging is promoted by CCR2+ macrophages and tissue-derived micro-environmental factors
The incidence of disorders associated with low inflammatory state, such as chronic kidney disease, increases in the elderly. The accumulation of...
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Aged mesenchymal stem cells and inflammation: from pathology to potential therapeutic strategies
Natural ageing of organisms and corresponding age-related diseases result mainly from stem cell ageing and “inflammaging”. Mesenchymal stem cells...
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Effect of miR-21 in mesenchymal stem cells-derived extracellular vesicles behavior
BackgroundA challenging new branch of research related to aging-associated diseases is the identification of miRNAs capable of modulating the...
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Systemic inflammation and biological aging in the Health and Retirement Study
Chronic, low-level systemic inflammation associated with aging, or inflammaging, is a risk factor for several chronic diseases and mortality. Using...
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TXNRD1 drives the innate immune response in senescent cells with implications for age-associated inflammation
Sterile inflammation, also known as ‘inflammaging’, is a hallmark of tissue aging. Cellular senescence contributes to tissue aging, in part, through...
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The potential role of necroptosis in inflammaging and aging
An age-associated increase in chronic, low-grade sterile inflammation termed “inflammaging” is a characteristic feature of mammalian aging that shows...
