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Genome-wide DNA methylation profiling in differentiating Crohn’s disease from intestinal tuberculosis
BackgroundDifferential diagnosis of Crohn’s disease (CD) and intestinal tuberculosis (ITB) is still difficult in clinical pratice. DNA methylation...
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DNA methylation analysis identifies key transcription factors involved in mesenchymal stem cell osteogenic differentiation
BackgroundKnowledge about regulating transcription factors (TFs) for osteoblastogenesis from mesenchymal stem cells (MSCs) is limited. Therefore, we...
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Centenarian clocks: epigenetic clocks for validating claims of exceptional longevity
Claims surrounding exceptional longevity are sometimes disputed or dismissed for lack of credible evidence. Here, we present three DNA...
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Data mining-based identification of epigenetic signatures with discrimination potential of lung adenocarcinoma and squamous cell carcinoma
BackgroundMounting evidence suggests that lung adenocarcinoma (LAC) and lung squamous cell carcinoma (LSC) have different biological behaviors and...
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Comparative epigenomics by machine learning approach for neuroblastoma
BackgroundNeuroblastoma (NB) is the second most common pediatric solid tumor. Because the number of genetic mutations found in tumors are small, even...
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Identification of an epigenetic signature in human induced pluripotent stem cells using a linear machine learning model
The use of human induced pluripotent stem cells (iPSCs), used as an alternative to human embryonic stem cells (ESCs), is a potential solution to...
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Common DNA methylation dynamics in endometriod adenocarcinoma and glioblastoma suggest universal epigenomic alterations in tumorigenesis
Trends in altered DNA methylation have been defined across human cancers, revealing global loss of methylation (hypomethylation) and focal gain of...
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Equivalent DNA methylation variation between monozygotic co-twins and unrelated individuals reveals universal epigenetic inter-individual dissimilarity
BackgroundAlthough the genomes of monozygotic twins are practically identical, their methylomes may evolve divergently throughout their lifetime as a...
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DNA methylation associated with healthy aging of elderly twins
Variation in healthy aging and lifespan is ascribed more to various non-genetic factors than to inherited genetic determinants, and a major goal in...
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Sex influences DNA methylation and gene expression in human skeletal muscle myoblasts and myotubes
BackgroundSex differences are known to impact muscle phenotypes, metabolism, and disease risk. Skeletal muscle stem cells (satellite cells) are...
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Circadian oscillations of cytosine modification in humans contribute to epigenetic variability, aging, and complex disease
BackgroundMaintenance of physiological circadian rhythm plays a crucial role in human health. Numerous studies have shown that disruption of...
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Regional methylome profiling reveals dynamic epigenetic heterogeneity and convergent hypomethylation of stem cell quiescence-associated genes in breast cancer following neoadjuvant chemotherapy
BackgroundNeoadjuvant chemotherapy (NAC) induces a pathological complete response (pCR) in ~ 30% of patients with breast cancer. However, aberrant...
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The role of GRHL2 and epigenetic remodeling in epithelial–mesenchymal plasticity in ovarian cancer cells
Cancer cells exhibit phenotypic plasticity during epithelial–mesenchymal transition (EMT) and mesenchymal–epithelial transition (MET) involving...
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Integration of DNA methylation patterns and genetic variation in human pediatric tissues help inform EWAS design and interpretation
BackgroundThe widespread use of accessible peripheral tissues for epigenetic analyses has prompted increasing interest in the study of...
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Impact on birth weight of maternal smoking throughout pregnancy mediated by DNA methylation
BackgroundCigarette smoking has severe adverse health consequences in adults and in the offspring of mothers who smoke during pregnancy. One of the...
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Epigenome-wide exploratory study of monozygotic twins suggests differentially methylated regions to associate with hand grip strength
Hand grip strength is a measure of muscular strength and is used to study age-related loss of physical capacity. In order to explore the biological...
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DNA hypermethylation enhanced telomerase reverse transcriptase expression in human-induced pluripotent stem cells
During reprogramming into human induced pluripotent stem cells (iPSCs), several stem cell marker genes are induced, such as OCT - 4 , NANOG , SALL4 , and TERT...
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Comprehensive evaluation of genome-wide 5-hydroxymethylcytosine profiling approaches in human DNA
BackgroundThe discovery that 5-methylcytosine (5mC) can be oxidized to 5-hydroxymethylcytosine (5hmC) by the ten-eleven translocation (TET) proteins...
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Distinctive epigenomes characterize glioma stem cells and their response to differentiation cues
BackgroundGlioma stem cells (GSCs) are a subpopulation of stem-like cells that contribute to glioblastoma (GBM) aggressiveness, recurrence, and...
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The dynamics of smoking-related disturbed methylation: a two time-point study of methylation change in smokers, non-smokers and former smokers
BackgroundThe evidence for epigenome-wide associations between smoking and DNA methylation continues to grow through cross-sectional studies....
