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Validation of quercetin in the treatment of colon cancer with diabetes via network pharmacology, molecular dynamics simulations, and in vitro experiments
This study built a prognostic model for CRC-diabetes and analyzed whether quercetin could be used for CRC-diabetes treatment through a network of...
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Canine Mucosal Artificial Colon: development of a new colonic in vitro model adapted to dog sizes
AbstractDifferences in dog breed sizes are an important determinant of variations in digestive physiology, mainly related to the large intestine. In...
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In Vitro Human Gastrointestinal Tract Simulation Systems: A Panoramic Review
Simulated human gastrointestinal (GI) tract systems are important for their applications in the fields of probiotics, nutrition and health. To date,...
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A child is not an adult: development of a new in vitro model of the toddler colon
AbstractEarly life is a critical period where gut ecosystem and functions are being established with significant impact on health. For regulatory,...
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Prebiotic fibre mixtures counteract the manifestation of gut microbial dysbiosis induced by the chemotherapeutic 5-Fluorouracil (5-FU) in a validated in vitro model of the colon
Background5-Fluorouracil (5-FU) is used as an antineoplastic agent in distinct cancer types. Increasing evidence suggests that the gut microbiota...
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Comparative analysis of the gut microbiota cultured in vitro using a single colon versus a 3-stage colon experimental design
AbstractThe importance of the gut microbiota in human health and disease progression makes it a target for research in both the biomedical and...
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Weaning-associated feed deprivation stress causes microbiota disruptions in a novel mucin-containing in vitro model of the piglet colon (MPigut-IVM)
BackgroundRisk factors for the etiology of post-weaning diarrhea, a major problem in swine industry associated with enormous economic losses, remain...
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The mechanisms of action of prenylated xanthones against breast, colon, and lung cancers, and their potential application against drug resistance
Cancers such as breast, colon, and lung cancers are among the leading causes of death with alarming increases in the number of new diagnoses and...
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Role of folic acid in regulating gut microbiota and short-chain fatty acids based on an in vitro fermentation model
AbstractFolic acid deficiency is common worldwide and is linked to an imbalance in gut microbiota. However, based on model animals used to study the...
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In vitro and in vivo fermentation models to study the function of dietary fiber in pig nutrition
AbstractThe importance of dietary fiber (DF) in animal diets is increasing with the advancement of nutritional research. DF is fermented by gut...
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Molecular docking and simulation studies of squalene obtained from Amaranthus Hybridus with DNA topoisomerase II alpha
DNA-Topoisomerases (DNA-Topo) are universal nuclear enzymes which deal with the DNA topology during cellular activities. These are the important and...
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An in vitro fermentation model to study the impact of bacteriophages targeting Shiga toxin-encoding Escherichia coli on the colonic microbiota
Lytic bacteriophages are considered safe for human consumption as biocontrol agents against foodborne pathogens, in particular in ready-to-eat...
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Impact of a fermented soy beverage supplemented with acerola by-product on the gut microbiota from lean and obese subjects using an in vitro model of the human colon
AbstractThe aim of this study was to evaluate the effects of soy-based beverages manufactured with water-soluble soy extract, containing probiotic...
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Three-dimensional in vitro culture models in oncology research
Cancer is a multifactorial disease that is responsible for 10 million deaths per year. The intra- and inter-heterogeneity of malignant tumors make it...
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High throughput in vitro characterization of pectins for pig(let) nutrition
BackgroundFiber-rich feed components possess prebiotic potential to enhance pig health and are considered a potential solution to the high prevalence...
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Three compounds from banana pseudostem inhibit mitotic cell division by interacting with tubulin and cyclin-dependent kinase 2 proteins: in vivo, in vitro and in silico approach
To identify putative antimitotic compounds, the pseudostem of banana plant (PSBP) was chosen and assays were carried out with aqueous extract of...
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Salmonella Typhimurium ST313 isolated in Brazil revealed to be more invasive and inflammatory in murine colon compared to ST19 strains
Salmonella Typhimurium (ST313) has caused an epidemic of invasive disease in sub-Saharan Africa and has been recently identified in Brazil. As the...
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Improved Bacterial Survival and Antioxidant Activity After In Vitro Digestion of Fermented Dairy Beverages by Lacticaseibacillus casei LC-01 and Lactiplantibacillus plantarum BG-112 Containing Yacon
The fermentation of milk containing 0%, 3%, 6%, and 9% (w/v) yacon root flour (YRF) by Lacticaseibacillus casei LC-1 and Lactiplantibacillus plantarum ...
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Generation of Colon Cancer Model Based on Colonoscopy Injection
Colorectal cancer animal model is a very useful tool to explore the tumor initiation and development. In the past year, many methods have been used...
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In vitro, in vivo, and in silico analysis of synbiotics as preventive interventions for lipid metabolism in ethanol-induced adipose tissue injury
The risk of alcoholic liver disease (ALD) is increased by excessive ethanol drinking. For the prevention of ALD, the effects of ethanol on the liver,...
