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Fast quantification of gut bacterial species in cocultures using flow cytometry and supervised classification
A bottleneck for microbial community experiments with many samples and/or replicates is the fast quantification of individual taxon abundances, which...
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In silico and in vitro analysis of the impact of single substitutions within EXO-motifs on Hsa-MiR-1246 intercellular transfer in breast cancer cell
MiR-1246 has recently gained much attention and many studies have shown its oncogenic role in colorectal, breast, lung, and ovarian cancers. However,...
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In silico tissue generation and power analysis for spatial omics
As spatially resolved multiplex profiling of RNA and proteins becomes more prominent, it is increasingly important to understand the statistical...
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A Review of the in Silico Design and Development Approaches of Ras-Specific Anticancer Therapeutics
Ras Proteins, play a pivotal role in the proliferation pathways, and Ras mutant forms are well-established cancer drivers. Ras mutations are found in...
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Antiproliferative Activity of Whey and Casein Bioactive Peptides on Breast Cancer: An In Vitro and In Silico Study
Bioactive peptides from milk proteins are dietary components with various biological properties and therapeutic effects in a variety of health...
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Inducing apoptosis by using microRNA in radio-resistant prostate cancer: an in-silico study with an in-vitro validation
BackgroundOne of the problems with radiation therapy (RT) is that prostate tumor cells are often radio-resistant, which results in treatment failure....
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Bioinspired thiazolo-[2,3-b] quinazolin-6-one derivatives as potent anti-cancer agents targeting EGFR: their biological evaluations and in silico assessment
Cancer is a challenging and second most deadly disease. The epidermal growth factor receptors (EGFRs) dimerize upon ligand bindings to the...
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Thiazole- and Coumarin-Conjugated (β-Lactam Scaffold) Azetidinones Synthesis and Their Substitution Effect in In Silico, and In Vitro Cell Viability Studies
AbstractIn present pandemic situations, we need more and more care on the medication, to treat the ill cells or to control the growth of the cells we...
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Evaluation of the Antitumor Potential of Soloxolone Tryptamide against Glioblastoma Multiforme Using in silico, in vitro, and in vivo Approaches
AbstractGlioblastoma multiforme (GBM) is a highly aggressive brain tumor characterized by uncontrollable diffusive growth, resistance to chemo- and...
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In silico insight of cell-death-related proteins in photosynthetic cyanobacteria
Cyanobacteria are a large group of ubiquitously found photosynthetic prokaryotes that are constantly exposed to different kinds of stressors of...
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Proteoglycan Expression Studied by MicroRNAs
MicroRNAs are small noncoding RNAs that regulate gene expression at the posttranscriptional level. Proteoglycans are glycoproteins characterized by...
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In vitro biological and in silico molecular docking and ADME studies of a substituted triazine-coordinated cadmium(II) ion: efficient cytotoxicity, apoptosis, genotoxicity, and nuclease-like activity plus binding affinity towards apoptosis-related proteins
A cadmium(II) complex containing dppt ligand with the formula [CdCl 2 (dppt) 2 ], where dppt is 5,6-diphenyl-3-(2-pyridyl)-1,2,4-triazine was...
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In silico and in vitro studies for the identification of small molecular inhibitors from Euphorbia hirta Linn for rheumatoid arthritis: targeting TNF-α-mediated inflammation
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that is now potentially lethal and has a significant detrimental influence on...
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Real-Time Flow Cytometry as a Tool to Monitor Cellular Consequences of P2X7 Activation in Multiple Cell Populations Mixed in a Single FACS Tube
The P2X7 receptor is an ATP-gated ion channel expressed by cells of the immune system. In murine T cells, P2X7 activation by high concentrations of...
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Experimental identification and in silico prediction of bacterivory in green algae
While algal phago-mixotrophs play a major role in aquatic microbial food webs, their diversity remains poorly understood. Recent studies have...
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Anticancer activity of N-heteroaryl acetic acid salts against breast cancer; in silico and in vitro investigation
BackgroundThe present research was performed to assess N-heteroaryl acetic acid salts' anticancer activity against the breast cancer cell in order to...
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In silico design and in vitro expression of novel multiepitope DNA constructs based on HIV-1 proteins and Hsp70 T-cell epitopes
ObjectivesEpitope-driven vaccines carrying highly conserved and immunodominant epitopes have emerged as promising approaches to overcome human...
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In silico molecular modelling studies and antibiofilm efficacy of shikonin against Candida albicans: mechanistic insight
In the recent past, the occurrence of fungal infections has increased drastically and candidiasis, caused prominently by Candida albicans, is...
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In silico high throughput screening and in vitro validation of a novel Raf/Mek dual inhibitor against colorectal carcinoma
Activation of the Raf/Mek pathway is critical in colorectal cancers (CRC). Several activating mutations have been reported in CRC, where activation...
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Deepometry, a framework for applying supervised and weakly supervised deep learning to imaging cytometry
Deep learning offers the potential to extract more than meets the eye from images captured by imaging flow cytometry. This protocol describes the...
