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Development of an In Vitro Model for Inflammation Mediated Renal Toxicity Using 3D Renal Tubules and Co-Cultured Human Immune Cells
Background: The emergence of various infectious diseases and the toxic effects of hyperinflammation by biotherapeutics have highlighted the need for in...
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Indole-3-carbinol in vitro antiviral activity against SARS-Cov-2 virus and in vivo toxicity
The effects of indole-3-carbinol (I3C) compound have been described deeply as antitumor drug in multiple cancers. Herein, I3C compound was tested for...
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Assessment of Salicylic Acid as a Pretreatment on Alleviating Cadmium Toxicity on In Vitro Banana Shoots
Heavy metals affect human health through the physical contact with polluted soil, polluted water, and food contaminated with toxic metals. Cadmium...
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The Toxicity of a New Monophenolic Synthetic Inducer of Keap1/Nrf2/ARE Redox-Sensitive Signaling System In Vitro and In Vivo
AbstractDevelopment of “indirect antioxidants” capable of activating redox-sensitive signaling systems, primarily the Keap1/Nrf2/ARE system, is a...
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Unveiling the emerging role of curcumin to alleviate ochratoxin A-induced muscle toxicity in grass carp (Ctenopharyngodon idella): in vitro and in vivo studies
BackgroundOchratoxin A (OTA), a globally abundant and extremely hazardous pollutant, is a significant source of contamination in aquafeeds and is...
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Guidelines on Developmental Toxicity Tests: Brief Insights
Developmental toxicology is a constantly evolving research field which needs to attend to a complex underlying regulatory network. In order to ensure...
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Toxicity Studies of Exosomes and Potential Overcome Approaches
Exosomes are nanosized, tiny extracellular particles that are produced by cells. They include varying quantities of protein, mRNA, miRNA, DNA, and...
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Protective effect of resveratrol against cadmium-induced toxicity on ovine oocyte in vitro maturation and fertilization
BackgroundHeavy metal cadmium (Cd) is a widespread environmental contaminant with a potential toxicity that might negatively affect female...
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Molecular Toxicity Mechanism of PPCPs in the Reservoir
Due to the ubiquitous environmental occurrence and associated health risks, pharmaceuticals and personal care products (PPCPs) as emerging...
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Crop Responses to Metal Toxicity
Sustainable crop production is the key to global food security. With progress in industrialization, threats of pollution have increased, and one of...
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Mitochondrial dysfunction is underlying fluoroquinolone toxicity: an integrated mitochondrial toxicity assessment
BackgroundAntibiotics bear an inherent risk of mitochondrial toxicity due to the structural similarities between mitochondria and bacteria....
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In Vitro Assay for Determining Cyanotoxin Using Cell Line Method: Hepatotoxicity (Cell Lines—HepG2, Caco-2, and V79)
Harmful cyanobacterial blooms are increasing and becoming a worldwide concern as many bloom-forming cyanobacterial species can produce toxic...
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Chromium Toxicity in Plants: An Overview of Plant Signaling
Natural occurrences of the element chromium (Cr) include rocky soils, volcanic dust, solid debris, chemicals used in batteries, industrial waste,...
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Molecular Toxicity Mechanism of Persistent Organic Pollutants (POPs) in the Reservoir
Due to the ubiquitous environmental existence, persistent organic pollutants (POPs) and their harmful effects have drawn attention among scientific...
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Cadmium toxicity and autophagy: a review
Cadmium (Cd) is an important environmental pollutant that poses a threat to human health and represents a critical component of air pollutants, food...
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In vitro and In vivo analysis of probiotic yeasts for dietary supplementation in Indian major carps
Five probiotic yeast strains viz. Yarrowia lipolytica VIT-MN01, Kluyveromyces lactis VIT-MN02, Lipomyces starkeyi VIT-MN03, Saccharomycopsis fibuligera ...
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Assessing the Potential Role of Zinc Oxide Nanoparticles for Mitigating Cadmium Toxicity in Capsicum annuum L. Under In Vitro Conditions
The application of metal and metal-oxide nanoparticles (NPs) in agriculture to mitigate the abiotic environmental stress factors and pollutants has...
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Neutral Red Uptake Assay to Assess Cytotoxicity In Vitro
The neutral red uptake (NRU) assay is a cell viability assay that can be used for the assessment of compound-induced cytotoxicity. It is based on the...
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Neurodevelopmental toxicity assessment of flame retardants using a human DNT in vitro testing battery
Due to their neurodevelopmental toxicity, flame retardants (FRs) like polybrominated diphenyl ethers are banned from the market and replaced by...
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Cypermethrin-Induced Reproductive Toxicity in Zebrafish: Biochemical and Molecular Perspective
Cypermethrin is the most commonly used synthetic pesticide to control different pest populations. Its increased production and wide applications can...