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Genomic Imprinting and Random Monoallelic Expression
AbstractThe review discusses the mechanisms of monoallelic expression, such as genomic imprinting, in which gene transcription depends on the...
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Immune imprinting and next-generation coronavirus vaccines
Vaccines based on historical virus isolates provide limited protection from continuously evolving RNA viruses, such as influenza viruses or...
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Along the Bos taurus genome, uncover candidate imprinting control regions
BackgroundIn mammals, Imprinting Control Regions (ICRs) regulate a subset of genes in a parent-of-origin-specific manner. In both human and mouse,...
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Imprinting at the KBTBD6 locus involves species-specific maternal methylation and monoallelic expression in livestock animals
BackgroundThe primary differentially methylated regions (DMRs) which are maternally hypermethylated serve as imprinting control regions (ICRs) that...
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The mismatch-repair proteins MSH2 and MSH6 interact with the imprinting control regions through the ZFP57-KAP1 complex
BackgroundImprinting Control Regions (ICRs) are CpG-rich sequences acquiring differential methylation in the female and male germline and maintaining...
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Conservation and divergence of canonical and non-canonical imprinting in murids
BackgroundGenomic imprinting affects gene expression in a parent-of-origin manner and has a profound impact on complex traits including growth and...
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Early Olfactory Learning in Mammals: A Case of Imprinting?
In many mammals, various social interactions are guided by olfactory cues, whereby olfactory preferences often form early in ontogeny. Early...
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EpiTy**: analysis of epigenetic aberrations in parental imprinting and X-chromosome inactivation using RNA-seq
Human pluripotent stem cells (hPSCs) hold a central role in studying human development, in disease modeling and in regenerative medicine. These cells...
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FOXA1 prevents nutrients deprivation induced autophagic cell death through inducing loss of imprinting of IGF2 in lung adenocarcinoma
Lung cancer remains one of the most common malignancies and the leading cause of cancer-related death worldwide. Forkhead box protein A1 (FOXA1) is a...
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Genomic Imprinting
A typical cell contains two sets of chromosomes: one that was inherited from the mother, the other from the father. Usually, autosomal alleles are...
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Allele-specific H3K9me3 and DNA methylation co-marked CpG-rich regions serve as potential imprinting control regions in pre-implantation embryo
Parental DNA methylation and histone modifications undergo distinct global reprogramming in mammalian pre-implantation embryos, but the landscape of...
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Placental imprinting of SLC22A3 in the IGF2R imprinted domain is conserved in therian mammals
BackgroundThe eutherian IGF2R imprinted domain is regulated by an antisense long non-coding RNA, Airn , which is expressed from a differentially...
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Genomic Imprinting: A Paradigm for Epigenetics of Human Diseases
Genomic imprinting is a remarkable phenomenon through which certain genes show monoallelic expression depending on their parent of origin. While...
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Epigenetic Regulation Disturbances on Gene Expression in Imprinting Diseases
Abstract—Epigenetic regulation is hereditary and non-hereditary changes in the expression of a particular gene without any corresponding structural...
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Transcriptional and imprinting complexity in Arabidopsis seeds at single-nucleus resolution
Seeds are a key life cycle stage for many plants. Seeds are also the basis of agriculture and the primary source of calories consumed by humans
1 ....
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The evolution of imprinting in plants: beyond the seed
Genomic imprinting results in the biased expression of alleles depending on if the allele was inherited from the mother or the father. Despite the...
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Evolutionary Aspects of Genomic Imprinting
Abstract—Genomic imprinting is an epigenetic phenomenon that differentiates maternal and paternal copies of genes in the genome and causes...
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Seed tuber imprinting shapes the next-generation potato microbiome
BackgroundPotato seed tubers are colonized and inhabited by soil-borne microbes, that can affect the performance of the emerging daughter plant in...
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A novel imprinted locus on bovine chromosome 18 homologous with human chromosome 16q24.1
Genomic imprinting is an epigenetic regulation mechanism in mammals resulting in the parentally dependent monoallelic expression of genes. Imprinting...
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Discovering candidate imprinted genes and imprinting control regions in the human genome
BackgroundGenomic imprinting is a process thereby a subset of genes is expressed in a parent-of-origin specific manner. This evolutionary novelty is...
