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Fatty acid profile of Apis mellifera workers in the face of an immune challenge
Fatty acids (FAs) are important in metabolism and in the maintenance of Apis mellifera colonies. Our objective was to identify the variation in FA...
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Gene expression response of Litopenaeus vannamei crustins in two specialized immune-related tissues upon Vibrio immersion challenge
The aim of this study was to characterize the transcriptional response of representative genes from the four crustin types (Type I, Lv Crustin Ia-6...
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The expanded inhibitor of apoptosis gene family in oysters possesses novel domain architectures and may play diverse roles in apoptosis following immune challenge
BackgroundApoptosis plays important roles in a variety of functions, including immunity and response to environmental stress. The Inhibitor of...
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Chronic immune challenge is detrimental to female survival, feeding behavior, and reproduction in the field cricket Gryllus assimilis (Fabricius, 1775)
Physiological trade-offs among expensive fitness-related traits, such as reproduction and immunity, are common in life histories of animals. An...
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Forum on immune digital twins: a meeting report
Medical digital twins are computational models of human biology relevant to a given medical condition, which are tailored to an individual patient,...
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Extracellular vesicles mediated gastric cancer immune response: tumor cell death or immune escape?
Gastric cancer (GC) is a major global health issue, being the fifth most prevalent cancer and the third highest contributor to cancer-related deaths....
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Tumor immune escape: extracellular vesicles roles and therapeutics application
BackgroundImmune escape, a process by which tumor cells evade immune surveillance, remains a challenge for cancer therapy. Tumor cells produce...
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Effects of immune challenge on expression of life-history and immune trait expression in sexually reproducing metazoans—a meta-analysis
BackgroundLife-history theory predicts a trade-off between investment into immune defence and other fitness-related traits. Accordingly, individuals...
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Single-cell immune repertoire analysis
Single-cell T cell and B cell antigen receptor-sequencing data analysis can potentially perform in-depth assessments of adaptive immune cells that...
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JAK/STAT mediated insulin resistance in muscles is essential for effective immune response
BackgroundThe metabolically demanding nature of immune response requires nutrients to be preferentially directed towards the immune system at the...
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Transposable elements expression in Rhinella marina (cane toad) specimens submitted to immune and stress challenge
Transposable elements (TEs) are important components of eukaryotic genomes and compose around 30% of the genome of Rhinella marina , an invasive toad...
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Map** the functional interactions at the tumor-immune checkpoint interface
The interactions between tumor intrinsic processes and immune checkpoints can mediate immune evasion by cancer cells and responses to immunotherapy....
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Shrimp Immune System and Immune Responses
Shrimp, being an invertebrate, lack a vertebrate-like adaptive immune system. However, an efficient innate immune system, consisting of physical...
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Exploring the crosstalk between endothelial cells, immune cells, and immune checkpoints in the tumor microenvironment: new insights and therapeutic implications
The tumor microenvironment (TME) is a highly intricate milieu, comprising a multitude of components, including immune cells and stromal cells, that...
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Characterization of a membrane Fcγ receptor in largemouth bass (Micropterus saloumoides) and its response to bacterial challenge
Fc receptors (FcRs), specific to the Fc portion of immunoglobulin (Ig), are required to regulate immune responses against pathogenic infections....
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TLR5 agonists enhance anti-tumor immunity and overcome resistance to immune checkpoint therapy
Primary and adaptive resistance to immune checkpoint therapies (ICT) represent a considerable obstacle to achieving enhanced overall survival. Innate...
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Modulating the growth, immune/antioxidant traits, immune-related genes, and resistance to Aeromonas veronii infection in Oreochromis niloticus reared under high stocking densities by dietary Lavandula angustifolia essential oil
In this study, we investigated the effects of the dietary addition of lavender essential oil (LEO) on mitigating the adverse effects of high stocking...
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The miR-29 family facilitates the activation of NK-cell immune responses by targeting the B7-H3 immune checkpoint in neuroblastoma
Neuroblastoma (NB) is a highly aggressive pediatric cancer that originates from immature nerve cells, presenting significant treatment challenges due...
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Immune Evasive Stem Cell Islets
Type 1 diabetes (T1D) is an autoimmune disease caused by the destruction of insulin-secreting β cells by the immune system (American Diabetes, A.,...
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Evaluation of vaccine candidates against Rhodococcus equi in BALB/c mice infection model: cellular and humoral immune responses
Rhodococcus equi ( R. equi ) is a zoonotic opportunistic pathogen that mainly causes fatal lung and extrapulmonary abscesses in foals and...
