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Idarubicin combats abiraterone and enzalutamide resistance in prostate cells via targeting XPA protein
Although second-generation therapies like abiraterone (ABI) and enzalutamide (ENZ) benefit patients with castration-resistant prostate cancer (CRPC),...
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Low-Dose Triptolide Enhanced Activity of Idarubicin Against Acute Myeloid Leukemia Stem-like Cells Via Inhibiting DNA Damage Repair Response
Leukemia stem cells (LSCs) are considered to be the root of relapse for acute myeloid leukemia (AML). Conventional chemotherapeutic drugs fail to...
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Anthracycline-induced cytotoxicity in the GL261 glioma model system
Glioblastoma (GBM) is a lethal astrocyte-derived tumor that is currently treated with a multi-modal approach of surgical resection, radiotherapy, and...
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1, 4-naphthoquinone efficiently facilitates the disintegration of pre-existing biofilm of Staphylococcus aureus through eDNA intercalation
1, 4-naphthoquinone, a plant-based quinone derivative, has gained much attention for its effectiveness against several biofilm-linked diseases. The...
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An overview of arsenic trioxide-involved combined treatment algorithms for leukemia: basic concepts and clinical implications
Arsenic trioxide is a first-line treatment drug for acute promyelocytic leukemia, which is also effective for other kinds of leukemia. Its side...
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Early changes in gene expression profiles in AML patients during induction chemotherapy
BackgroundElucidation of the genetic mechanisms underlying treatment response to standard induction chemotherapy in AML patients is warranted, in...
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MSI2 promotes translation of multiple IRES-containing oncogenes and virus to induce self-renewal of tumor initiating stem-like cells
AbstractRNA-binding protein Musashi 2 (MSI2) is elevated in several cancers and is linked to poor prognosis. Here, we tested if MSI2 promotes MYC and...
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Clinical Studies and Epi-Drugs in Various Cancer Types
Cancer is characterized by modifications in the epigenetic mechanisms and chromatin functions. Alterations in gene expression, as well as the...
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Establishment and characterization of NCC-MRT1-C1: a novel cell line of malignant rhabdoid tumor
Malignant rhabdoid tumor (MRT) is a sarcoma histologically characterized by rhabdoid cells and genetically characterized by loss of function of the...
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Establishment and characterization of NCC-MPNST6-C1: a novel patient-derived cell line of malignant peripheral nerve sheath tumors
Malignant peripheral nerve sheath tumors (MPNSTs) are a rare subtype of mesenchymal tumors that arise from the sheath of peripheral nerves. MPNSTs...
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Chemotherapy and mismatch repair deficiency cooperate to fuel TP53 mutagenesis and ALL relapse
Chemotherapy is a standard treatment for pediatric acute lymphoblastic leukemia (ALL), which sometimes relapses with chemoresistant features....
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Exploring the nexus of nuclear receptors in hematological malignancies
Hematological malignancies (HM) represent a subset of neoplasms affecting the blood, bone marrow, and lymphatic systems, categorized primarily into...
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A rare KMT2A::CBL transcript in an acute monoblastic leukemia patient with an unfavorable outcome
BackgroundLysine [K] methyltransferase 2A ( KMT2A , previously known as MLL ) gene rearrangements are common in acute leukemias of various lineages and...
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Cardiovascular Adverse Effects of Breast Cancer Chemotherapy
Breast cancer is the most commonly diagnosed cancer globally, with more than 2.3 million cases per year and resulting in the death of 685,000 women...
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Catheter-associated blood stream infections due to Candida pararugosa in a patient with acute myeloid leukemia: A case report
Infections caused by uncommon Candida species have dramatically increased in recent decades, mostly among hematological malignancies. This report...
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Epigenetic Modifiers and Their Inhibitors in Leukemia Treatment
It seems quite unlikely that any adult cancer may arise as the result of single gene defect. Epigenetic alterations have been described in AML and...
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Network integration and modelling of dynamic drug responses at multi-omics levels
Uncovering cellular responses from heterogeneous genomic data is crucial for molecular medicine in particular for drug safety. This can be realized...
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NSP15
Endoribonuclease NSP15Endoribonuclease NSP15 is vital for the replication and life cycle of the SARS-CoV-2 virus and is thus considered a compelling...
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Type I interferon signaling in malignant blasts contributes to treatment efficacy in AML patients
While type I interferon (IFN) is best known for its key role against viral infection, accumulating preclinical and clinical data indicate that robust...
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Recent advances in pluripotent stem cell-derived cardiac organoids and heart-on-chip applications for studying anti-cancer drug-induced cardiotoxicity
Cardiovascular disease (CVD) caused by anti-cancer drug-induced cardiotoxicity is now the second leading cause of mortality among cancer survivors....
