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Altered cfDNA fragmentation profile in hypomethylated regions as diagnostic markers in breast cancer
BackgroundBreast cancer, the most common malignancy in women worldwide, has been proven to have both altered plasma cell-free DNA (cfDNA) methylation...
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DNA methylome analysis provides insights into gene regulatory mechanism for better performance of rice under fluctuating environmental conditions: epigenomics of adaptive plasticity
Main conclusionRoots play an important role in adaptive plasticity of rice under dry/direct-sown conditions. However, hypomethylation of genes in...
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X-chromosome inactivation in human iPSCs provides insight into X-regulated gene expression in autosomes
BackgroundVariation in X chromosome inactivation (XCI) in human-induced pluripotent stem cells (hiPSCs) can impact their ability to model biological...
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DDM1-mediated gene body DNA methylation is associated with inducible activation of defense-related genes in Arabidopsis
BackgroundPlants memorize previous pathogen attacks and are “primed” to produce a faster and stronger defense response, which is critical for defense...
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Transcriptomic evaluation of N6-methyladenosine modification can be used to identify differentially gene and immune-related biological processes in TX mice with liver fibrosis
BackgroundN6-methyladenosine (m6A) modification controls the stability, splicing, and translation of mRNA, which is important in the development of...
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Gene body hypomethylation of pyroptosis-related genes NLRP7, NLRP2, and NLRP3 facilitate non-invasive surveillance of hepatocellular carcinoma
Programmed cell death (PCD) resistance is a key driver of cancer occurrence and development. The prognostic relevance of PCD-related genes in...
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SETDB1 deletion causes DNA demethylation and upregulation of multiple zinc-finger genes
BackgroundSETDB1 (SET domain bifurcated-1) is a histone H3-lysine 9 (H3K9)-specific methyltransferase that mediates heterochromatin formation and...
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Hypermethylated genome of a fish vertebrate iridovirus ISKNV plays important roles in viral infection
Iridoviruses are nucleocytoplasmic large dsDNA viruses that infect invertebrates and ectothermic vertebrates. The hypermethylated genome of...
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Investigating FGFR2 gene as a blood-based epigenetic biomarker in gastric cancer
BackgroundGastric adenocarcinoma is a prevalent form of cancer that often remains undetected in its early stages due to the lack of specific...
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Disruption of maternal vascular remodeling by a fetal endoretrovirus-derived gene in preeclampsia
BackgroundPreeclampsia, one of the most lethal pregnancy-related diseases, is associated with the disruption of uterine spiral artery remodeling...
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Placental methylome reveals a 22q13.33 brain regulatory gene locus associated with autism
BackgroundAutism spectrum disorder (ASD) involves complex genetics interacting with the perinatal environment, complicating the discovery of common...
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Integrative analysis of transcriptomic and epigenomic data reveals distinct patterns for developmental and housekee** gene regulation
BackgroundRegulation of transcription is central to the emergence of new cell types during development, and it often involves activation of genes via...
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Dynamic changes in whole genome DNA methylation, chromatin and gene expression during mouse lens differentiation
BackgroundCellular differentiation is marked by temporally and spatially coordinated gene expression regulated at multiple levels. DNA methylation...
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Association of lipid metabolism-related gene promoter methylation with risk of coronary artery disease
Background:Coronary artery disease (CAD) is a complex disease that is influenced by environmental and genetic factors. Lipid levels are regarded as a...
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Epigenetic regulation of seed-specific gene expression by DNA methylation valleys in castor bean
BackgroundUnderstanding the processes governing angiosperm seed growth and development is essential both for fundamental plant biology and for...
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Orientation of mouse H19 ICR affects imprinted H19 gene expression through promoter methylation-dependent and -independent mechanisms
The mouse Igf2/H19 locus is regulated by genomic imprinting, in which the paternally methylated H19 imprinting control region (ICR) plays a critical...
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Modulation of neural gene networks by estradiol in old rhesus macaque females
The postmenopausal decrease in circulating estradiol (E2) levels has been shown to contribute to several adverse physiological and psychiatric...
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Gene-Targeted DNA Methylation: Towards Long-Lasting Reprogramming of Gene Expression?
DNA methylation is an essential epigenetic mark, strongly associated with gene expression regulation. Aberrant DNA methylation patterns underlie...
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Resetting histone modifications during human prenatal germline development
Histone modifications play critical roles in regulating gene expression and present dynamic changes during early embryo development. However, how...
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Repetitive element transcript accumulation is associated with inflammaging in humans
Chronic, low-grade inflammation increases with aging, contributing to functional declines and diseases that reduce healthspan. Growing evidence...
