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Promoter hypermethylation of neural-related genes is compatible with stemness in solid cancers
BackgroundDNA hypermethylation is an epigenetic feature that modulates gene expression, and its deregulation is observed in cancer. Previously, we...
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DNMT1/DNMT3a-mediated promoter hypermethylation and transcription activation of ICAM5 augments thyroid carcinoma progression
Promoter methylation is one of the most studied epigenetic modifications and it is highly relevant to the onset and progression of thyroid carcinoma...
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DNA methyltransferase 3a-induced hypermethylation of the fructose-1,6-bisphosphatase-2 promoter contributes to gastric carcinogenesis
BackgroundAberrant DNA methylation has been implicated in the development of gastric cancer (GC). In our previous study, we demonstrated that...
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TRIM29 hypermethylation drives esophageal cancer progression via suppression of ZNF750
Esophageal cancer (ESCA) is the seventh most frequent and deadly neoplasm. Due to the lack of early diagnosis and high invasion/metastasis, the...
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Pan-cancer analysis revealed H3K4me1 at bivalent promoters premarks DNA hypermethylation during tumor development and identified the regulatory role of DNA methylation in relation to histone modifications
BackgroundDNA hypermethylation at promoter CpG islands (CGIs) is a hallmark of cancers and could lead to dysregulation of gene expression in the...
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Neuroepigenetic alterations in the prefrontal cortex of type 2 diabetic mice through DNA hypermethylation
BackgroundDNA methylation changes have known to downregulate several regulatory proteins epigenetically during various neurodegenerative disorders....
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CRL4DCAF13 E3 ubiquitin ligase targets MeCP2 for degradation to prevent DNA hypermethylation and ensure normal transcription in growing oocytes
The DNA methylation is gradually acquired during oogenesis, a process sustained by successful follicle development. However, the functional roles of...
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DNMT1 driven by mouse amniotic fluid mesenchymal stem cell exosomes improved corneal cryoinjury via inducing microRNA-33 promoter DNA hypermethylation modification in corneal epithelium cells
Severe corneal cryoinjury can cause permanent corneal swelling and bullous keratopathy, one of the main reason for loss of sight. Mouse amniotic...
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Chromosome-specific retention of cancer-associated DNA hypermethylation following pharmacological inhibition of DNMT1
The DNA methylation status of the X-chromosome in cancer cells is often overlooked because of computational difficulties. Most of the CpG islands on...
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What are the roles of global DNA and APC 2 gene promotor hypermethylation in multiple myeloma?
BackgroundIn today's practice, gene-based approaches come to the fore in the determination of prognosis and treatment preferences of multiple myeloma...
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DNA hypermethylation modification promotes the development of hepatocellular carcinoma by depressing the tumor suppressor gene ZNF334
DNA methylation plays a pivotal role in the development and progression of tumors. However, studies focused on the dynamic changes of DNA methylation...
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DNA demethylation and hypermethylation are both required for late nodule development in Medicago
Plant epigenetic regulations are involved in transposable element silencing, developmental processes and responses to the environment
1 –7 . They often...
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Hypermethylation of microRNA-497-3p contributes to progression of thyroid cancer through activation of PAK1/β-catenin
MicroRNA-497 (miR-497) has been reported to be a tumor-suppressive miRNA in thyroid cancer (TC), yet the mechanism is not clearly defined. In this...
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Hypermethylation of the Bmp4 promoter dampens binding of HIF-1α and impairs its cardiac protective effects from oxidative stress in prenatally GC-exposed offspring
The exposure to an unhealthy environment in utero can lead to the occurrence of cardiovascular diseases in the offspring. Glucocorticoids (GC) are...
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The Association between Hypermethylation of Gene Promoters and Cytogenetic Disturbances in Humans Exposed to Radiation as a Result of the Chernobyl Accident
Abstract—The estimation of hypermethylation of the cell cycle ( RASSF1A, p16/INK4A, p14/ARF ) and detoxification ( GSTP1 ) gene promoters was carried...
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Detection of hypermethylation BRCA1/2 gene promoter in breast tumours among Moroccan women
BackgroundThe promoter region is a key element of gene expression regulation. In mammals, most of the genes present, at the level of their promoter,...
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Nuclear receptor subfamily 3 group c member 2 (NR3C2) is downregulated due to hypermethylation and plays a tumor-suppressive role in colon cancer
Nuclear receptor subfamily 3 group c member 2 (NR3C2) has been reported to function as a tumor suppressor in several tumors. However, the clinical...
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Embryo CHH hypermethylation is mediated by RdDM and is autonomously directed in Brassica rapa
BackgroundRNA-directed DNA methylation (RdDM) initiates cytosine methylation in all contexts and maintains asymmetric CHH methylation. Mature plant...
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RIPK3 promoter hypermethylation in hepatocytes protects from bile acid-induced inflammation and necroptosis
Necroptosis facilitates cell death in a controlled manner and is employed by many cell types following injury. It plays a significant role in various...
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Ginkgo biloba Extract Attenuates the Disruption of Pro- and Anti-inflammatory Balance of Peripheral Blood in Arsenism Patients by Decreasing Hypermethylation of the Foxp3 Promoter Region
Coal-burning type of arsenism, a chronic arsenism caused by environmental arsenic pollution, found firstly at Guizhou Province of China, manifested...
