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1. Hydrogen Peroxide and Its Role in Abiotic Stress Tolerance in Plants

   Plants are continuously subjected to numerous abiotic stresses such as heavy metal, salinity, drought, high temperature, cold and ozone etc. which...

   Syed Nazar ul Islam, Mohd Asgher, Nafees A. Khan in Gasotransmitters Signaling in Plant Abiotic Stress

   Chapter 2023
   

2. Heat Stress Modulates Superoxide and Hydrogen Peroxide Dismutation and Starch Synthesis during Tuber Development in Potato

   Potato production is being affected by high temperature stresses worldwide due to global warming. The biological basis of carbohydrate metabolism and...

   Jobadatun Naher, Zahid Hasan Sabuj, ... Ujjal Kumar Nath in American Journal of Potato Research

   Article 13 May 2024
   

3. Activation of Nrf2/HO-1 signaling pathway exacerbates cholestatic liver injury

   Nuclear factor erythroid 2-related factor-2 (Nrf2) antioxidant signaling is involved in liver protection, but this generalization overlooks...

   Yi Wang, **aolong Fu, ... Shaoyu Zhou in Communications Biology

   Article Open access 23 May 2024
   

4. Plasma membrane aquaporins of the PIP1 and PIP2 subfamilies facilitate hydrogen peroxide diffusion into plant roots

   Background

   The permeability of plasma membrane aquaporins (PIPs) to small solutes other than water greatly diversifies their potential functions in...

   David Israel, Seong Hee Lee, ... Janusz Jerzy Zwiazek in BMC Plant Biology

   Article Open access 05 December 2022
   

5. Sirtuin4 alleviates severe acute pancreatitis by regulating HIF-1α/HO-1 mediated ferroptosis

   Acute pancreatitis (AP) is a common emergency of the digestive system and serious cases can develop into severe acute pancreatitis (SAP), which...

   Yanna Liu, Huning Cui, ... Changju Zhu in Cell Death & Disease

   Article Open access 21 October 2023
   

6. Aucubin Alleviates Chronic Obstructive Pulmonary Disease by Activating Nrf2/HO-1 Signaling Pathway

   Background

   Chronic obstructive pulmonary disease (COPD) is a common chronic respiratory disease with high death rates. Aucubin is an iridoid glycoside...

   Ting Liu, Yang Li, Nan Hu in Cell Biochemistry and Biophysics

   Article 05 July 2024
   

7. Prognostic value of Nrf2/HO-1 expression and its correlation with occurrence in esophageal squamous cell carcinoma

   Background

   Esophageal squamous cell carcinoma (ESCC) is thought to be started and developed by genes associated with inflammation. A cancer's ability...

   Yongmei Gao, Mengyan Li, ... Yuqing Ma in Genes & Genomics

   Article 12 April 2023
   

8. HSP70 protects PC12 cells against TBHP-induced apoptosis and oxidative stress by activating the Nrf2/HO-1 signaling pathway

   HSP70 exhibits neuroprotective, antioxidant, and anti-apoptotic properties, which are crucial in preventing spinal cord injury (SCI) induced by...

   Bo Deng, Xuegang He, ... Xuewen Kang in In Vitro Cellular & Developmental Biology - Animal

   Article 28 May 2024
   

9. A soil-borne Mn(II)-oxidizing bacterium of Providencia sp. exploits a strategy of superoxide production coupled to hydrogen peroxide consumption to generate Mn oxides

   Bacterial non-enzymatic Mn(II) oxidation involving reactive oxygen species (ROS) (i.e., indirect oxidation), initially discovered from a marine...

   Sha Chen, Zhexu Ding, ... Ding Li in Archives of Microbiology

   Article 12 February 2022
   

10. 5-Aminolevulinic acid combined with ferrous iron ameliorates scrotal heat stress-induced spermatogenic damage by enhancing HO-1 expression

    Objective

    To explore whether 5-Aminolevulinic acid combined with ferrous iron (5-ALA/Fe ²⁺ ) could protect testicular tissues damage of mice subjected...

    Peng Gao, **gming Zhuang, ... Jiangang Hou in Molecular Biology Reports

    Article 22 April 2023
    

11. Sodium humate ameliorates LPS-induced liver injury in mice by inhibiting TLR4/NF-κB and activating NRF2/HO-1 signaling pathways

    Background

    Acute liver damage is a type of liver disease that has a significant global occurrence and a lack of successful treatment and prevention...

    Weiming Ma, Kexin Liu, ... Dong Wang in Molecular Biology Reports

    Article 25 January 2024
    

12. Activation of Nrf2/HO-1 antioxidant signaling correlates with the preventive effect of loganin on oxidative injury in ARPE-19 human retinal pigment epithelial cells

    Background

    Loganin, a type of iridoid glycoside derived from Corni Fructus, is known to have beneficial effects various chronic diseases. However,...

    Yung Hyun Choi in Genes & Genomics

    Article 26 August 2022
    

13. Curcumol ameliorates neuroinflammation after cerebral ischemia–reperfusion injury via affecting microglial polarization and Treg/Th17 balance through Nrf2/HO-1 and NF-κB signaling

    Neuroinflammation caused by microglia and other immune cells plays pivotal role in cerebral ischemia/reperfusion injury and recovery. Modulating...

    Ying Liu, Wen Wang, ... Jiangyong Miao in Cell Death Discovery

    Article Open access 24 June 2024
    

14. Alleviation of Plant Stress by Molecular Hydrogen

    Gasotransmitters and gaseous-signaling molecules are hugely important for controlling cell function and especially so during stress challenges. Past...

    John T. Hancock, Tyler W. LeBaron, ... Grace Russell in Gasotransmitters Signaling in Plants under Challenging Environment

    Chapter 2023
    

15. Valuable effects of lactobacillus and citicoline on steatohepatitis: role of Nrf2/HO-1 and gut microbiota

    Non-alcoholic steatohepatitis (NASH) is a more dangerous form of chronic non-alcoholic fatty liver disease (NAFLD). In the current investigation, the...

    Ahmed M. El-Baz, Amira M. El-Ganiny, ... Ahmed A. Shabaan in AMB Express

    Article Open access 08 June 2023
    

16. Differential catalase activity and tolerance to hydrogen peroxide in the filamentous cyanobacteria Nostoc punctiforme ATCC 29133 and Anabaena sp. PCC 7120

    Photoautotrophic cyanobacteria often confront hydrogen peroxide (H ₂ O ₂ ), a reactive oxygen species potentially toxic to cells when present in...

    Loknath Samanta, Karin Stensjö, ... Jyotirmoy Bhattacharya in Archives of Microbiology

    Article 07 January 2022
    

17. Protective Role of Myricetin and Fisetin Against Nephrotoxicity Caused by Lead Acetate Exposure through Up-regulation of Nrf2/HO-1 Signalling Pathway

    The effect of various flavonoids against oxidative stress and inflammation caused by lead exposure has been investigated. However, the protective...

    Mehmet Berköz, Ayhan Yiğit, Mirosław Krośniak in Biological Trace Element Research

    Article 05 December 2023
    

18. Hydrogen therapy as a potential therapeutic intervention in heart disease: from the past evidence to future application

    Cardiovascular disease is the leading cause of mortality worldwide. Excessive oxidative stress and inflammation play an important role in the...

    Kwannapas Saengsin, Rekwan Sittiwangkul, ... Nipon Chattipakorn in Cellular and Molecular Life Sciences

    Article 03 June 2023
    

19. Fenton Reaction in vivo and in vitro. Possibilities and Limitations

    Abstract

    The review considers the problem of hydrogen peroxide decomposition and hydroxyl radical formation in the presence of iron in vivo and in vitro...

    Konstantin O. Muranov in Biochemistry (Moscow)

    Article 01 January 2024
    

20. HO-1 nuclear accumulation and interaction with NPM1 protect against stress-induced endothelial senescence independent of its enzymatic activity

    Heme oxygenase-1 (HO-1) has attracted accumulating attention for its antioxidant enzymatic activity. However, the exact regulatory role of its...

    Wenwei Luo, **gyan Li, ... Zhuoming Li in Cell Death & Disease

    Article Open access 26 July 2021