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Human zygotic genome activation is initiated from paternal genome
Although parental genomes undergo extensive epigenetic reprogramming to be equalized after fertilization, whether they play different roles in human...
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The Wheat Genome
This open access book provides the first comprehensive coverage of the wheat genome sequence since the publication of the draft and reference...
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Inversion polymorphism in a complete human genome assembly
The telomere-to-telomere (T2T) complete human reference has significantly improved our ability to characterize genome structural variation. To...
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Repetitive DNA sequence detection and its role in the human genome
Repetitive DNA sequences playing critical roles in driving evolution, inducing variation, and regulating gene expression. In this review, we...
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Genome Rearrangement Analysis
Genome rearrangements are mutations that change the gene content of a genome or the arrangement of the genes on a genome. Several years of research...
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Comparative Genome Annotation
Newly sequenced genomes are being added to the tree of life at an unprecedented fast pace. A large proportion of such new genomes are...
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A systematic comparison of human mitochondrial genome assembly tools
BackgroundMitochondria are the cell organelles that produce most of the chemical energy required to power the cell's biochemical reactions. Despite...
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Characterization of large-scale genomic differences in the first complete human genome
BackgroundThe first telomere-to-telomere (T2T) human genome assembly (T2T-CHM13) release is a milestone in human genomics. The T2T-CHM13 genome...
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Genome
All genetic information is recorded in one or a few DNA molecules that constitute an organism’s genome. Although the cells of an organism vary...
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A genome-wide association study reveals the relationship between human genetic variation and the nasal microbiome
The nasal cavity harbors diverse microbiota that contributes to human health and respiratory diseases. However, whether and to what extent the host...
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Efficient engineering of human and mouse primary cells using peptide-assisted genome editing
Simple, efficient and well-tolerated delivery of CRISPR genome editing systems into primary cells remains a major challenge. Here we describe an...
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Genome-wide association study identifies human genetic variants associated with fatal outcome from Lassa fever
Infection with Lassa virus (LASV) can cause Lassa fever, a haemorrhagic illness with an estimated fatality rate of 29.7%, but causes no or mild...
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A genome catalog of the early-life human skin microbiome
BackgroundMetagenome-assembled genomes have greatly expanded the reference genomes for skin microbiome. However, the current reference genomes are...
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Shared and distinct interactions of type 1 and type 2 Epstein-Barr Nuclear Antigen 2 with the human genome
BackgroundThere are two major genetic types of Epstein-Barr Virus (EBV): type 1 (EBV-1) and type 2 (EBV-2). EBV functions by manipulating gene...
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Remnants of SIRE1 retrotransposons in human genome?
Evolution is unaimed changes in time that a genome is shaped by a collection of random mutations, recombination, integrations, and reorganizations....
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Investigating the dark-side of the genome: a barrier to human disease variant discovery?
The human genome contains regions that cannot be adequately assembled or aligned using next generation short-read sequencing technologies. More than...
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Boosting genome editing efficiency in human cells and plants with novel LbCas12a variants
BackgroundCas12a (formerly known as Cpf1), the class II type V CRISPR nuclease, has been widely used for genome editing in mammalian cells and plants...
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A high-quality genome compendium of the human gut microbiome of Inner Mongolians
Metagenome-based resources have revealed the diversity and function of the human gut microbiome, but further understanding is limited by insufficient...
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Reconstruction of the personal information from human genome reads in gut metagenome sequencing data
Human DNA present in faecal samples can result in a small number of human reads in gut shotgun metagenomic sequencing data. However, it is presently...
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Technologies Promoting Genome-Based Taxonomy
Whole-genome sequencing (WGS) has proven to be a reliable method. Additionally, it is a commonly used approach in research and surveillance...