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Inhibition of WNT/β-catenin signalling during sex-specific gonadal differentiation is essential for normal human fetal testis development
Sex-specific gonadal differentiation is directed by complex signalling promoting development in either male or female direction, while simultaneously...
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Isolation and In Vitro Culture of Germ Cells and Sertoli Cells from Human Fetal Testis
In the human fetal testis, fetal germ cells (FGCs) are progressively surrounded by supporting Sertoli cells inside seminiferous cords. During the...
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The New Roles of traf6 Gene Involved in the Development of Zebrafish Liver and Gonads
Traf6, an adaptor protein, exhibits non-conventional E3 ubiquitin ligase activity and was well studied as an important factor in immune systems and...
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Multipotent fetal stem cells in reproductive biology research
Due to the limited accessibility of the in vivo situation, the scarcity of the human tissue, legal constraints, and ethical considerations, the...
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Reconstitution of Human Prospermatogonial Development from Human-Induced Pluripotent Stem Cells
There is a scarcity of information regarding the molecular mechanisms underlying human germ cell development due to limitations in obtaining the...
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In vitro testicular organogenesis from human fetal gonads produces fertilization-competent spermatids
Unlike most organs that mature during the fetal period, the male reproductive system reaches maturity only at puberty with the commencement of...
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Modeling Human Gonad Development in Organoids
BACKGROUND:Our learning about human reproductive development is greatly hampered due to the absence of an adequate model. Animal studies cannot...
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COUP-TFII regulates early bipotential gonad signaling and commitment to ovarian progenitors
BackgroundThe absence of expression of the Y-chromosome linked testis-determining gene SRY in early supporting gonadal cells (ESGC) leads...
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Micronutrient supplementation affects DNA methylation in male gonads with potential intergenerational epigenetic inheritance involving the embryonic development through glutamate receptor-associated genes
BackgroundDNA methylation has an important role in intergenerational inheritance. An increasing number of studies have reported evidence of germline...
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RNA m6A modification regulates L1 retrotransposons in human spermatogonial stem cell differentiation in vitro and in vivo
The maintenance of genome integrity in the germline is crucial for mammalian development. Long interspersed element type 1 (LINE-1, L1) is a mobile...
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Tmsb10 triggers fetal Leydig differentiation by suppressing the RAS/ERK pathway
Leydig cells in fetal testes play crucial roles in masculinizing fetuses through androgen production. Gene knockout studies have revealed that growth...
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Dissecting the epigenomic dynamics of human fetal germ cell development at single-cell resolution
Proper development of fetal germ cells (FGCs) is vital for the precise transmission of genetic and epigenetic information through generations. The...
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Agrochemical Use and Emerging Human and Animal Diseases
In modern agriculture, the gap between food production and food consumption caused by the exponential increase in the global population is bridged...
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Resetting histone modifications during human prenatal germline development
Histone modifications play critical roles in regulating gene expression and present dynamic changes during early embryo development. However, how...
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Molecular diversity and phenotypic pleiotropy of ancient genomic regulatory loci derived from human endogenous retrovirus type H (HERVH) promoter LTR7 and HERVK promoter LTR5_Hs and their contemporary impacts on pathophysiology of Modern Humans
Timelines of population-level effects of viruses on humans varied from the evolutionary scale of million years to contemporary spread of viral...
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From in vivo to in vitro: exploring the key molecular and cellular aspects of human female gametogenesis
Human oogenesis is a highly complex and not yet fully understood process due to ethical and technological barriers that limit studies in the field....
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Human Primordial Germ Cell-Like Cell Induction from Pluripotent Stem Cells by SOX17 and PRDM1 Expression
Human primordial germ cell (PGC) development initiates about 2 weeks after fertilization during embryogenesis. Unique molecular events follow,...
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Apoptosis in the fetal testis eliminates developmentally defective germ cell clones
Many germ cells are eliminated during development, long before oogenesis or spermatogenesis. In mouse fetal testes, the majority of germ cell...
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The Evolutionary Route of in vitro Human Spermatogenesis: What is the Next Destination?
Malfunction in spermatogenesis due to genetic diseases, trauma, congenital disorders or gonadotoxic treatments results in infertility in...
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Organoids in the Human Reproductive System
Introduction: The limitation of using the animal as the model for studying human reproductive diseases is that the biological background of the...